Výsledky vyhledávání - "Alfons Enhsen"

Akademický článek

Substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters of the rabbit. I. Transport studies with membrane vesicles and cell lines expressing the cloned transporters

Autor: Werner Kramer, Siegfried Stengelin, Karl-Heinz Baringhaus, Alfons Enhsen, Hubert Heuer, Wolfgang Becker, Daniel Corsiero, Frank Girbig, Rüdiger Noll, Claudia Weyland

Publikováno v: Journal of Lipid Research, Vol 40, Iss 9, Pp 1604-1617 (1999)

The substrate specificity of the ileal and the hepatic Na+/bile acid cotransporters was determined using brush border membrane vesicles and CHO cell lines permanently expressing the Na+/bile acid cotransporters from rabbit ileum or rabbit liver. The

Externí odkaz: https://doaj.org/article/0bd38c9e399a469881c5111bbb621130

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Bile acids in drug discovery

Autor: Alfons Enhsen, Werner Kramer, Günther Wess

Publikováno v: Drug Discovery Today. 3:409-418

Recent advances have provided important new information on the physiological mechanisms of bile acid transport and metabolism. Bile acids, which are essential for the digestion and absorption of lipids and lipid-soluble vitamins, are metabolic produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b439dc9c32367a0681210e08a2ec0ab3
https://doi.org/10.1016/s1359-6446(96)10046-5

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Topological Photoaffinity Labeling of the Rabbit Ileal Na+/Bile-Salt-Cotransport System

Autor: Daniel Corsiero, Claudia Weyland, Hans-Ludwig Schäfer, Siegfried Stengelin, Frank Girbig, Alfons Enhsen, Günther Wess, Werner Kramer, Klaus Bock, Horst Kleine, Marie-Anne Le Dreau, Ulrike Bewersdorf

Publikováno v: European Journal of Biochemistry. 249:456-464

For the investigation of the topology of the rabbit ileal Na+/bile-salt-cotransport system, composed of a 93-kDa integral membrane protein and a peripheral 14-kDa bile-acid-binding protein (ILBP), we have synthesized photolabile dimeric bile-salt-tra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9775ed4af019f8ef23ee2083a2b14854
https://doi.org/10.1111/j.1432-1033.1997.00456.x

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Modified bile acids as carriers for peptides and drugs

Autor: Gerrit Schubert, Georg Neckermann, Günther Wess, Hoffmann Axel, Matthias Urmann, Alfons Enhsen, Werner Kramer, Eugen Falk

Publikováno v: Journal of Controlled Release. 46:17-30

For the development of future drugs two aspects are of major importance, a site-specific drug action without adverse side-effects and a preferably oral applicability. The liver has a central role in drug action and many disorders are unique to the li

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::dfa22c03af2b0762f08605858c33ff89
https://doi.org/10.1016/s0168-3659(96)01599-4

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Hepatobiliary transport of hepatic 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors conjugated with bile acids

Autor: Karl-Heinz Baringhaus, Jurgen A. Horz, Lutz Nickau, Siegfried Schulz, Alfons Enhsen, Ernst Petzinger, Eugen Falk, Hoffmann Axel, Georg Neckermann, Günther Wess, Werner Kramer, Stefan Müllner, Heiner Glombik

Publikováno v: Hepatology. 22:1801-1811

To obtain prodrugs with affinity to liver parenchymal cells, the hepatic 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors HR 780 and lovastatin (syn. mevinolin) were conjugated with the bile acids cholic acid, taurocholic acid, an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9a59ef706b5da691d21a73f5f09d58f4
https://doi.org/10.1002/hep.1840220629

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Synthesis and Biological Activity of Bile Acid-Derived HMG-CoA Reductase Inhibitors. The Role of 21-Methyl in Recognition of HMG-CoA Reductase and the Ileal Bile Acid Transport System

Autor: X B Han, Alfons Enhsen, Guenther Dr Wess, K.‐H. Baringhaus, Klaus Bock, Werner Kramer, Heiner Glombik, G Böger, A. Hoffmann, Matthias Urmann

Publikováno v: Journal of Medicinal Chemistry. 37:3240-3246

To increase hepatoselectivity of HMG-CoA reductase inhibitors by using the specific bile acid transport systems, deoxycholic acid-derived inhibitors 9 and 11 have been synthesized, on the basis of the concept of combining in one molecule structural r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a49ce28f590ac76a20fdd613a00b3d7
https://doi.org/10.1021/jm00046a007

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Synthesis of bile acid - drug conjugates: Potential drug - shuttles for liver specific targeting

Autor: H. Kleine, K.‐H. Baringhaus, M. John, W. Kramer, Klaus Bock, O. Neckermann, Alfons Enhsen, A. Hoffmann, Gerrit Schubert, Heiner Glombik, G. Wess, S. Müllner

Publikováno v: Tetrahedron Letters. 34:819-822

Cholic acid (1) has been coupled via ω-aminoalkoxy spacer at C-3 to chlorambucil (3), HR 780 (4) and oxaproline peptide (5). Drug conjugates 9, 11, 18 exhibit strong affinity to specific bile acid transport systems.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5bd9e6acfecda3cacebc6abc9217570
https://doi.org/10.1016/0040-4039(93)89021-h

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