Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alfons C. Wouterse"'
Autor:
Joris van Drongelen, Alfons C. Wouterse, David M. Burger, Angela Colbers, Marga Teulen, Vivienne Verweij, Stein Schalkwijk, Daphne van den Oetelaar, Rick Greupink, Frans G. M. Russel
Publikováno v:
Journal of Antimicrobial Chemotherapy, 71, 2, pp. 480-3
Journal of Antimicrobial Chemotherapy, 71, 480-3
Journal of Antimicrobial Chemotherapy, 71, 480-3
Contains fulltext : 168052.pdf (Publisher’s version ) (Closed access) OBJECTIVES: Data on fetal exposure to antiretroviral agents during pregnancy are important to estimate their potential for prevention of mother-to-child transmission (PMTCT) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2fac8ae9cb2815e8c552b55a2835559
https://hdl.handle.net/2066/168052
https://hdl.handle.net/2066/168052
Autor:
Otto C. Boerman, Alfons C. Wouterse, Janny G. P. Peters, Rosalinde Masereeuw, Femke M. van de Water, Frans G. M. Russel
Publikováno v:
Drug Metabolism and Disposition, 34, 1393-97
Drug Metabolism and Disposition, 34, 8, pp. 1393-97
Drug Metabolism and Disposition, 34, 8, pp. 1393-97
Different gene-silencing methods, like antisense and short interfering RNA (siRNA), are widely used as experimental tools to inhibit gene expression. In the present study, the in vivo behavior of siRNA in rats and siRNA-mediated silencing of genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::477357779f2be630f9e70b08b22c9d3f
https://doi.org/10.1124/dmd.106.009555
https://doi.org/10.1124/dmd.106.009555
Autor:
Alfons C. Wouterse, Paul Smits, L.D. Elving, Frans G. M. Russel, Eric A.P. Steegers, Tanya M. Bisseling
Publikováno v:
Diabetic Medicine, 22(4), 503-506. Wiley-Blackwell Publishing Ltd
Diabetic Medicine, 22, 503-6
Diabetic Medicine, 22, 4, pp. 503-6
Diabetic Medicine, 22, 503-6
Diabetic Medicine, 22, 4, pp. 503-6
Contains fulltext : 48788.pdf (Publisher’s version ) (Closed access) AIM: In diabetes, perinatal morbidity is significantly increased. This may partly be related to functional changes in the foetoplacental vascular bed. In diabetes models, a defect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d02c30f785bee4cb636a3070dd76a8e
https://doi.org/10.1111/j.1464-5491.2005.01437.x
https://doi.org/10.1111/j.1464-5491.2005.01437.x
Autor:
Wout Feitz, R.P.E. De Gier, D. Smits, Rosalinde Masereeuw, Alfons C. Wouterse, Frans G. M. Russel
Publikováno v:
BJU International. 92:452-458
OBJECTIVE: To study the pathophysiological changes of renal tubular drug transport mechanisms in congenital renal obstruction, by developing a model for perfusing the isolated kidney (IPK) after neonatal surgical induction of partial ureteric obstruc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::863b99dacd4d35e5876fcb6677bad542
https://doi.org/10.1046/j.1464-410x.2003.04352.x
https://doi.org/10.1046/j.1464-410x.2003.04352.x
Autor:
Frans G. M. Russel, Rosalinde Masereeuw, Alfons C. Wouterse, Pascal H. E. Smeets, Sylvia Notenboom
Publikováno v:
Journal of the American Society of Nephrology, 14, 11, pp. 2741-9
Journal of the American Society of Nephrology, 14, 2741-9
Journal of the American Society of Nephrology, 14, 2741-9
Contains fulltext : 142650.pdf (Publisher’s version ) (Closed access) Previous studies with mutant transport-deficient rats (TR(-)), in which the multidrug resistance protein 2 (Mrp2) is lacking, have emphasized the importance of this transport pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e2ce7e12da56177d0532511f1067501
https://hdl.handle.net/2066/142650
https://hdl.handle.net/2066/142650
Autor:
Richard Engbersen, Paul Smits, H.B.P.M. Dijkman, Cees Kramers, Frans G. M. Russel, Alfons C. Wouterse, Miek M. Moons
Publikováno v:
British Journal of Pharmacology. 130:1678-1684
Sulphonylurea drugs have been shown to protect against hypoxic damage in isolated proximal tubules of the kidney. In the present study we investigated whether these drugs can protect against hypoxic damage in a whole kidney preparation. Tolbutamide (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bdfcf93d083f7bd5522cfbdf8dfa4d7
https://doi.org/10.1038/sj.bjp.0703469
https://doi.org/10.1038/sj.bjp.0703469
Publikováno v:
Biochemical Pharmacology, 50, 11, pp. 1873-1878
Biochemical Pharmacology, 50, 1873-1878
Biochemical Pharmacology, 50, 1873-1878
The potency and nature of the inhibitory effect of various cationic drugs on the transport of choline across the placental syncytial microvillus membrane was investigated. Tetraethylammonium, a model substrate for organic cation transport, was a poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d06a3fc91934c5dbff216591896347
https://hdl.handle.net/2066/22320
https://hdl.handle.net/2066/22320
Autor:
E.M. van der Aa, A.C.M. Boersen, Alfons C. Wouterse, I.J.B. Meuwsen, Frans G. M. Russel, J.H.J. Copius Peereboom-Stegeman
Publikováno v:
Placenta. 15:279-289
The mechanism of uptake of p-aminohippurate (PAH) by syncytial microvillous membrane vesicles of human term placenta was investigated. Initial PAH uptake and efflux were increased in the presence of a pH-gradient and a Cl − -gradient, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ca089666e86393c92eadc3e18cde34b
https://doi.org/10.1016/0143-4004(94)90019-1
https://doi.org/10.1016/0143-4004(94)90019-1
Autor:
Jenny H.J. Copius Peereboom-Stegeman, Eric M. van der Aa, Alfons C. Wouterse, Frans G. M. Russel
Publikováno v:
Biochemical Pharmacology. 47:453-456
The uptake of the quaternary ammonium compound choline was studied in syncytial microvillus membrane vesicles of human term placenta. Uptake was stimulated by an inside negative membrane potential and by loading the vesicles with unlabeled choline. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f258abae0d6cdc121b260dbbe51bc69
https://doi.org/10.1016/0006-2952(94)90175-9
https://doi.org/10.1016/0006-2952(94)90175-9
Publikováno v:
Journal of Pharmacy and Pharmacology. 45:614-617
To investigate whether dogs are able to excrete acetylated drugs by active transport, the plasma kinetics and renal excretion of the N4-acetyl metabolites of sulphasomidine and sulphadimethoxine were studied in the beagle dog after a rapid intravenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb1ad8c16adc0e30de3ea79306643e4c
https://doi.org/10.1111/j.2042-7158.1993.tb05663.x
https://doi.org/10.1111/j.2042-7158.1993.tb05663.x