Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Alfiya G. Iksanova"'
Autor:
Nikita V. Shtyrlin, Mikhail V. Pugachev, Sergey V. Sapozhnikov, Marsel R. Garipov, Rusalia M. Vafina, Denis Y. Grishaev, Roman S. Pavelyev, Renata R. Kazakova, Mariya N. Agafonova, Alfiya G. Iksanova, Svetlana A. Lisovskaya, Marina I. Zeldi, Elena S. Krylova, Elena V. Nikitina, Alina E. Sabirova, Airat R. Kayumov, Yurii G. Shtyrlin
Publikováno v:
Molecules, Vol 25, Iss 18, p 4341 (2020)
A series of 108 novel quaternary bis-ammonium pyridoxine derivatives carrying various substituents at the quaternary nitrogen’s and acetal carbon was synthesized. Thirteen compounds exhibited antibacterial and antifungal activity (minimum inhibitor
Externí odkaz:
https://doaj.org/article/3173c442871045d0a08a8fd0266eb676
Autor:
A. Kayumov, Alfiya G. Iksanova, S. Sapozhnikov, M. Agafonova, Yurii G. Shtyrlin, M. Garipov, Mikhail V. Pugachev, R. Khaziev, Nikita V. Shtyrlin
Publikováno v:
материалы конференции.
Autor:
Mikhail V. Pugachev, Roman S. Pavelyev, Konstantin V. Balakin, Nikita V. Shtyrlin, A. S. Petukhov, Marsel R. Garipov, Alfiya G. Iksanova, Mikhail S. Dzyurkevich, Yurii G. Shtyrlin, A. D. Strel’nik
Publikováno v:
Russian Chemical Bulletin. 68:911-945
Pyridoxine and its derivatives, pyridoxamine and pyridoxal, are the three main forms of vitamin B6, which play exceptionally important biological roles in living organisms. The active endogenous metabolites of these molecules, pyridoxal phosphate and
Autor:
Raylya R. Gabbasova, Denis Yu. Grishaev, Timur M. Bulatov, Yurii G. Shtyrlin, Olga Kataeva, Alfiya G. Iksanova, Mikhail V. Pugachev, Bashar Aljondi, Oksana V. Bondar, Zilya Yamaleeva, Tatyana V. Nikishova, Roman S. Pavelyev, Konstantin V. Balakin, Thang N.T. Nguyen
Publikováno v:
Bioorganicmedicinal chemistry. 30
A new efficient approach to the synthesis of 6-alkenyl substituted pyridoxine derivatives has been developed. A series of 31 novel alkenyl pyridoxine derivatives, stilbene-based bioisosteric analogs of estradiol, were synthesized. In vitro cytotoxici
Autor:
Michail V. Pugachev, Tatyana V. Kupriyanova, Konstantin V. Balakin, Almaz A. Akhunzyanov, Alfiya G. Iksanova, Nikita V. Shtyrlin, Yurii G. Shtyrlin, Ruzalia M. Vafiva, Raylya R. Gabbasova
Publikováno v:
Anti-Cancer Drugs. 29:682-690
This work presents the results of in-vitro biological activity studies of three novel anticancer agents, phosphonium salts based on the 3-hydroxypyridine scaffold, including one derivative of 4-deoxypyridoxine. Proliferation and viability of cells tr
Autor:
Еlena S. Krylova, Denis Yu. Grishaev, Konstantin V. Balakin, Alfiya G. Iksanova, Yurii G. Shtyrlin, Nikita V. Shtyrlin, Еlena V. Nikitina, Alina E. Zamaldinova, Airat R. Kayumov, Sergey V. Sapozhnikov
Publikováno v:
Medicinal Chemistry Research. 26:3188-3202
A diverse library of 34 new quaternary mono-ammonium and bis-ammonium pyridoxine derivatives was synthesized, and their antibacterial activity against several clinically relevant bacterial strains was evaluated in vitro. Several mono-ammonium compoun
Autor:
Elena S. Krylova, Alan A. Akhmedov, Pavel L. Padnya, Yu. G. Shtyrlin, O.S. Terenteva, Nikita V. Shtyrlin, Ivan I. Stoikov, Alfiya G. Iksanova, Elena V. Nikitina
Publikováno v:
Bioorganic & Medicinal Chemistry. 29:115905
The search for new antibacterial and antiseptic drugs is an urgent problem due to the resistance of microorganisms to existing drugs. In this work, for the first time, the design of antibacterial and bactericidal agents based on quaternary ammonium c
Synthesis and antiadrenergic properties of β-substituted alcohols based on 6-hydroxymethylpyridoxine
Autor:
L. E. Ziganshina, N. N. Khaertdinov, Guzel F. Sitdikova, Olga A. Lodochnikova, S. A. Koshkin, Yu. G. Shtyrlin, E. G. Aleksandrova, R. R. Khairullina, Alfiya G. Iksanova, Roman S. Pavelyev, A. F. Safina
Publikováno v:
Russian Chemical Bulletin. 65:519-531
An approach to the synthesis of epoxides based on 6-hydroxymethylpyridoxine acetals was developed. The epoxides obtained were involved in the ring opening reactions by nitrogen-, oxygen-, and sulfur-containing nucleophiles. Cytotoxicity and antiadren
Autor:
R. M. Khaziev, Mikhail V. Pugachev, Alfiya G. Iksanova, Marina I. Zeldi, R. M. Vafina, Nikita V. Shtyrlin, Elena V. Nikitina, Yu. G. Shtyrlin
Publikováno v:
Russian Chemical Bulletin. 65:537-545
Methods for the synthesis of quaternary phosphonium salts based on 3-hydroxypyridine and 4-deoxypyridoxine were developed. Some of obtained compounds possess high antibacterial and antitumor activity in vitro.
Autor:
T. T. Nguyen, Olga A. Lodochnikova, Mikhail V. Pugachev, Yu. G. Shtyrlin, Alfiya G. Iksanova, Roman S. Pavelyev
Publikováno v:
Russian Chemical Bulletin. 65:532-536
A convenient method for the synthesis of pyridoxine alkenyl derivatives by the Wittig reaction of [(2,8-dimethyl-4H-[1,3]dioxino[4,5-c]pyridin-5-yl)methyl]triphenylphosphonium chloride with aldehydes was suggested. Some of the compounds obtained exhi