Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alfiya Distler"'
Autor:
Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-2 (2021)
Externí odkaz:
https://doaj.org/article/4a79129265f14a77a70418593018ffaa
Autor:
Debomita Chakraborty, Barbora Šumová, Tatjana Mallano, Chih-Wei Chen, Alfiya Distler, Christina Bergmann, Ingo Ludolph, Raymund E. Horch, Kolja Gelse, Andreas Ramming, Oliver Distler, Georg Schett, Ladislav Šenolt, Jörg H. W. Distler
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
STAT3 is a transcription factor that is activated in fibrotic diseases such as systemic sclerosis. Here the authors show that STAT3 is the converging point for multiple pro-fibrotic signalling pathways, and that its genetic ablation or inhibition ame
Externí odkaz:
https://doaj.org/article/9c56fd268be941fcb1e830810f66f437
Autor:
Clara Dees, Philip Janiak, Bertrand Léger, Christian Beyer, Alfiya Distler, Josef Pernerstorfer, Jean Pierre Bidouard, Laetitia Ledein, Serena Vettori, Stephane Illiano, Rachid Boukaiba, Jörg H W Distler, Oliver Distler, Matthias Schaefer, Hartmut Ruetten, Alexandre Jagerschmidt
Publikováno v:
British Journal of Pharmacology
Background and purpose Genetic deletion and pharmacological studies suggest a role for lysophosphatidic acid (LPA1 ) receptor in fibrosis. We investigated the therapeutic potential in systemic sclerosis (SSc) of a new orally active selective LPA1 rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3461709fb9e09a11345ee3c0c728b42c
https://doi.org/10.1111/bph.15190
https://doi.org/10.1111/bph.15190
Autor:
Alfiya Distler, Kolja Gelse, Ingo Ludolph, Ladislav Šenolt, Jörg H W Distler, Barbora Šumová, Raymund E. Horch, Andreas Ramming, Christina Bergmann, Debomita Chakraborty, Tatjana Mallano, Oliver Distler, Georg Schett, Chih-Wei Chen
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
Nature Communications
Nature Communications
Signal transducer and activator of transcription 3 (STAT3) is phosphorylated by various kinases, several of which have been implicated in aberrant fibroblast activation in fibrotic diseases including systemic sclerosis (SSc). Here we show that profib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1400b0904b480895c1c93f161e3b9834
http://link.springer.com/article/10.1038/s41467-017-01236-6
http://link.springer.com/article/10.1038/s41467-017-01236-6
Autor:
Georg Schett, Adam Reich, Alfiya Distler, Jörg H W Distler, Chih-Wei Chen, Ruifang Liang, Clara Dees, Andreas Ramming, Yun Zhang, Oliver Distler, Kolja Gelse, Tatjana Mallano, Dirk Mielenz, Christina Bergmann
Publikováno v:
Annals of the Rheumatic Diseases. 76:1467-1475
ObjectivesJanus kinase 2 (JAK2) has recently been described as a novel downstream mediator of the pro-fibrotic effects of transforming growth factor-β. Although JAK2 inhibitors are in clinical use for myelodysplastic syndromes, patients often rapidl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56fc76a3feeb49e5de1e3748f0be441
https://doi.org/10.1136/annrheumdis-2016-210911
https://doi.org/10.1136/annrheumdis-2016-210911
Autor:
Jörg H W Distler, Katrin Palumbo-Zerr, Oliver Distler, Gerhard Krönke, Carina Scholtysek, Michal Tomcik, Dirk Mielenz, Jingang Huang, Clara Dees, Pawel Zerr, Rossella Mancuso, Georg Schett, Daniel Metzger, Barbara G. Fürnrohr, Christian Beyer, Judith Fliehr, Alfiya Distler
Publikováno v:
Nature Medicine. 21:150-158
Mesenchymal responses are an essential aspect of tissue repair. Failure to terminate this repair process correctly, however, results in fibrosis and organ dysfunction. Therapies that block fibrosis and restore tissue homeostasis are not yet available
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84d3885cbab368c8db35e129d3f3c24c
https://doi.org/10.1038/nm.3777
https://doi.org/10.1038/nm.3777
Autor:
Michal Tomcik, Jérôme Avouac, Holm Schneider, Oliver Distler, Katrin Palumbo-Zerr, Yannick Allanore, Georg Schett, Pawel Zerr, Jörg H W Distler, Clara Dees, Christian Beyer, Nadira Ruzehaji, Alfiya Distler
Publikováno v:
Arthritis & Rheumatology. 66:3140-3150
Objective Nuclear receptors regulate cell growth, differentiation, and homeostasis. Selective nuclear receptors promote fibroblast activation, which leads to tissue fibrosis, the hallmark of systemic sclerosis (SSc). This study was undertaken to inve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e967d7392a268a09c9a3e693fd622e0b
https://doi.org/10.1002/art.38819
https://doi.org/10.1002/art.38819
Autor:
Lucie Andrés Cerezo, Pawel Zerr, Barbora Šumová, Jérôme Avouac, Katrin Palumbo-Zerr, Jörg H W Distler, Christian Beyer, Mariam Grigorian, Michal Tomcik, Georg Schett, R. Becvar, Alfiya Distler, Ladislav Šenolt, Clara Dees, Oliver Distler
Publikováno v:
Annals of the Rheumatic Diseases. 74:1748-1755
Objectives S100A4 is a calcium binding protein with regulatory functions in cell homeostasis, proliferation and differentiation that has been shown to promote cancer progression and metastasis. In the present study, we evaluated the role of S100A4 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f2f84cc37faf282b45c04aeb4499b5f
https://doi.org/10.1136/annrheumdis-2013-204516
https://doi.org/10.1136/annrheumdis-2013-204516
Autor:
Pawel Zerr, Katrin Palumbo, Oliver Distler, Georg Schett, Yun Zhang, Alfiya Distler, Neng-Yu Lin, Laura Susok, Christian Beyer, Alexander Kreuter, Jörg H W Distler, Clara Dees
Publikováno v:
Annals of the Rheumatic Diseases. 74:936-943
Objectives: Casein kinase II (CK2) is a constitutively active serine/threonine protein kinase that plays a key role in cellular transformation and tumorigenesis. The purpose of the study was to characterise whether CK2 contributes to the pathologic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c1f6aa1ec06fd3917ea2875ff0aceea
https://doi.org/10.1136/annrheumdis-2013-204256
https://doi.org/10.1136/annrheumdis-2013-204256
Autor:
Britta Maurer, Alfiya Distler, Clara Dees, Korsa Khan, Christopher P Denton, David Abraham, Renate E Gay, Beat A Michel, Steffen Gay, Jörg HW Distler, Oliver Distler
Publikováno v:
Annals of the Rheumatic Diseases. 72:2039-2046
ObjectivesTo assess whether the discrepancy between the strong antifibrotic effects of tyrosine kinase inhibitors (TKIs) in animal models and the inconsistent results in clinical studies might be related to the activation levels of drug targets.Metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::315130e02ed55d3081e5546285bfe640
https://doi.org/10.1136/annrheumdis-2013-203729
https://doi.org/10.1136/annrheumdis-2013-203729