Repurposed AT9283 triggers anti-tumoral effects by targeting MKK3 oncogenic functions in Colorectal Cancer.

Autor: Piastra, Valentina^1,2 (AUTHOR), Ganci, Federica¹ (AUTHOR), Sacconi, Andrea¹ (AUTHOR), Pranteda, Angelina^1,2 (AUTHOR), Allegretti, Matteo¹ (AUTHOR), Bernardini, Roberta³ (AUTHOR), Serra, Martina^1,3 (AUTHOR), Lupo, Barbara^4,5 (AUTHOR), Dell'Aquila, Emanuela⁶ (AUTHOR), Ferretti, Gianluigi⁷ (AUTHOR), Pescarmona, Edoardo⁸ (AUTHOR), Bartolazzi, Armando⁹ (AUTHOR), Blandino, Giovanni¹ (AUTHOR), Trusolino, Livio^4,5 (AUTHOR), Bossi, Gianluca¹ (AUTHOR) gianluca.bossi@ifo.it

Publikováno v: Journal of Experimental & Clinical Cancer Research (17569966). 8/20/2024, Vol. 43 Issue 1, p1-18. 18p.

The scale of zebrafish pectoral fin buds is determined by intercellular K⁺ levels and consequent Ca²⁺-mediated signaling via retinoic acid regulation of Rcan2 and Kcnk5b.

Autor: Jiang, Xiaowen¹ (AUTHOR), Zhao, Kun¹ (AUTHOR), Sun, Yi¹ (AUTHOR), Song, Xinyue¹ (AUTHOR), Yi, Chao¹ (AUTHOR), Xiong, Tianlong¹ (AUTHOR), Wang, Sen¹ (AUTHOR), Yu, Yi^1,2 (AUTHOR), Chen, Xiduo¹ (AUTHOR), Liu, Run¹ (AUTHOR), Yan, Xin¹ (AUTHOR), Antos, Christopher L.^1,3 (AUTHOR) clantos@shanghaitech.edu.cn

Publikováno v: PLoS Biology. 3/25/2024, Vol. 22 Issue 3, p1-44. 44p.

Magnetic resonance imaging-guided intracranial resection of glioblastoma tumors in patient-derived orthotopic xenografts leads to clinically relevant tumor recurrence.

Autor: Oudin, Anais¹ (AUTHOR), Moreno-Sanchez, Pilar M.^1,2 (AUTHOR), Baus, Virginie¹ (AUTHOR), Niclou, Simone P.^1,2 (AUTHOR), Golebiewska, Anna¹ (AUTHOR) Anna.Golebiewska@lih.lu

Publikováno v: BMC Cancer. 1/2/2024, Vol. 24 Issue 1, p1-14. 14p.

Patient-derived xenograft (PDX) models in basic and translational breast cancer research.

Autor: Dobrolecki LE; The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA., Airhart SD; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Alferez DG; Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL, UK., Aparicio S; Department of Pathology and Laboratory Medicine, BC Cancer Agency, 675 W10th Avenue, Vancouver, V6R 3A6, Canada., Behbod F; Department of Pathology, University of Kansas Medical Center, |3901 Rainbow Blvd, WHE 1005B, Kansas City, KS, 66160, USA., Bentires-Alj M; Department of Biomedicine, University of Basel, University Hospital Basel, Lab 306, Hebelstrasse 20, CH-4031, Basel, Switzerland., Brisken C; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland., Bult CJ; The Jackson Laboratory, Bar Harbor, ME, 04609, USA., Cai S; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Clarke RB; Breast Cancer Now Research Unit, Division of Molecular and Clinical Cancer Sciences, Manchester Cancer Research Centre, University of Manchester, Wilmslow Road, Manchester, M21 4QL, UK., Dowst H; Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX, 77030, USA., Ellis MJ; The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA., Gonzalez-Suarez E; Cancer Epigenetics and Biology Program, PEBC, Bellvitge Institute for Biomedical Research, IDIBELL, Av. Gran Via de L'Hospitalet, 199-203, 08908 L'Hospitalet de Llobregat, Barcelona, Spain., Iggo RD; INSERM U1218, Bergonié Cancer Institute, 229 cours de l'Argonne, 33076, Bordeaux, France., Kabos P; Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Li S; Department of Internal Medicine, Washington University, St. Louis, MO, 63130, USA., Lindeman GJ; Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medicine, The University of Melbourne, Parkville, VIC, 3010, Australia.; Familial Cancer Centre, Royal Melbourne Hospital, Peter MacCallum Cancer Centre, Grattan St, Parkville, VIC, 3050, Australia., Marangoni E; Translational Research Department, Institut Curie, 26, rue d'Ulm, 75005, Paris, France., McCoy A; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Meric-Bernstam F; Departments of Investigational Cancer Therapeutics and Breast Surgical Oncology, UT M. D. Anderson Cancer Center, Houston, TX, 77030, USA., Piwnica-Worms H; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Poupon MF; Founder and Scientific Advisor, XenTech SA, Genopole, 4 rue Pierre Fontaine, 91000, Evry, France., Reis-Filho J; Director of Experimental Pathology, Department of Pathology, Affiliate Member, Human Oncology and Pathogenesis Program, and Center for Computational Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Sartorius CA; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA., Scabia V; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland., Sflomos G; School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL), ISREC-Swiss Institute for Experimental Cancer Research, SV2.832 Station 19, 1015, Lausanne, Switzerland., Tu Y; Department of Experimental Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA., Vaillant F; Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia., Visvader JE; Stem Cells and Cancer Division, Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC, 3052, Australia.; Department of Medical Biology, University of Melbourne, Parkville, VIC, 3010, Australia., Welm A; Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT, 84112, USA., Wicha MS; Madeline and Sidney Forbes Professor of Oncology, Director, Forbes Institute for Cancer Discovery, NCRC 26-335S, SPC 2800 2800 Plymouth Rd, Ann Arbor, MI, 48109-2800, USA., Lewis MT; The Lester and Sue Smith Breast Center, Departments of Molecular and Cellular Biology and Radiology, Baylor College of Medicine, Houston,, TX, 77030, USA. mtlewis@bcm.edu.

Publikováno v: Cancer metastasis reviews [Cancer Metastasis Rev] 2016 Dec; Vol. 35 (4), pp. 547-573.

The role of pyroptosis and gasdermin family in tumor progression and immune microenvironment.

Autor: Li, Mengyuan¹ (AUTHOR), Jiang, Ping¹ (AUTHOR), Yang, Yuhan¹ (AUTHOR), Xiong, Liting¹ (AUTHOR), Wei, Shuhua¹ (AUTHOR), Wang, Junjie¹ (AUTHOR) junjiewang_edu@sina.cn, Li, Chunxiao¹ (AUTHOR) chunxiaoli@pku.edu.cn

Publikováno v: Experimental Hematology & Oncology. 12/8/2023, Vol. 12 Issue 1, p1-24. 24p.