Unbiased plasma proteomics discovery of biomarkers for improved detection of subclinical atherosclerosis

Autor: Núñez, Estefanía, Fuster, Valentín, Gómez-Serrano, María, Valdivielso, José Manuel, Fernández-Alvira, Juan Miguel, Martínez-López, Diego, Rodríguez, José Manuel, Bonzon-Kulichenko, Elena, Calvo, Enrique, Alfayate, Alvaro, Bermudez-Lopez, Marcelino, Escola-Gil, Joan Carles, Fernández-Friera, Leticia, Cerro-Pardo, Isabel, Mendiguren, José María, Sánchez-Cabo, Fátima, Sanz, Javier, Ordovás, José María, Blanco-Colio, Luis Miguel, García-Ruiz, José Manuel, Ibáñez, Borja, Lara-Pezzi, Enrique, Fernández-Ortiz, Antonio, Martín-Ventura, José Luis, Vázquez, Jesús

Publikováno v: In eBioMedicine February 2022 76

Aortic disease in Marfan syndrome is caused by overactivation of sGC-PRKG signaling by NO

Autor: de la Fuente-Alonso, Andrea, Toral, Marta, Alfayate, Alvaro, Ruiz-Rodríguez, María Jesús, Bonzon-Kulichenko, Elena, Teixido-Tura, Gisela, Martínez-Martínez, Sara, Méndez-Olivares, María José, López-Maderuelo, Dolores, González-Valdés, Ileana, Garcia-Izquierdo, Eusebio, Mingo, Susana, Martín, Carlos E., Muiño-Mosquera, Laura, De Backer, Julie, Nistal, J. Francisco, Forteza, Alberto, Evangelista Masip, Arturo, Vázquez, Jesús, Campanero, Miguel R., Redondo, Juan Miguel, Universidad Autònoma de Barcelona

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Scientia
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Thoracic aortic aneurysm, as occurs in Marfan syndrome, is generally asymptomatic until dissection or rupture, requiring surgical intervention as the only available treatment. Here, we show that nitric oxide (NO) signaling dysregulates actin cytoskel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c59f75159e5cfeb220282358ebef2fd
https://pubmed.ncbi.nlm.nih.gov/33976159