Activation of COX-2/PGE2 Promotes Sapovirus Replication via the Inhibition of Nitric Oxide Production

Autor: Alfajaro, MM, Choi, J-S, Kim, D-S, Seo, J-Y, Kim, J-Y, Park, J-G, Soliman, M, Baek, Y-B, Cho, E-H, Kwon, J, Kwon, H-J, Park, S-J, Lee, WS, Kang, M-I, Hosmillo, M, Goodfellow, I, Cho, K-O

Enteric caliciviruses in the genera Norovirus and Sapovirus are important pathogens that cause severe acute gastroenteritis in both humans and animals. Cyclooxygenases (COXs) and their final product, prostaglandin E2 (PGE2), are known to play importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______109::7bad2129361da51925776ffffe375db4
https://www.repository.cam.ac.uk/handle/1810/262414

SARS-CoV-2-related bat viruses evade human intrinsic immunity but lack efficient transmission capacity.

Autor: Peña-Hernández MA; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Alfajaro MM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Filler RB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Moriyama M; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Keeler EL; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Ranglin ZE; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Kong Y; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Mao T; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Menasche BL; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Mankowski MC; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Zhao Z; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Vogels CBF; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Hahn AM; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Kalinich CC; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Zhang S; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA., Huston N; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA., Wan H; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA., Araujo-Tavares R; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA., Lindenbach BD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA., Homer R; Department of Pathology, Yale School of Medicine, New Haven, CT, USA., Pyle AM; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA.; Department of Chemistry, Yale University, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Martinez DR; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA., Grubaugh ND; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA., Israelow B; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA.; Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT, USA., Iwasaki A; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. akiko.iwasaki@yale.edu.; Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT, USA. akiko.iwasaki@yale.edu.; Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT, USA. akiko.iwasaki@yale.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. akiko.iwasaki@yale.edu., Wilen CB; Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. craig.wilen@yale.edu.; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA. craig.wilen@yale.edu.

Publikováno v: Nature microbiology [Nat Microbiol] 2024 Aug; Vol. 9 (8), pp. 2038-2050. Date of Electronic Publication: 2024 Jul 29.

Differences in syncytia formation by SARS-CoV-2 variants modify host chromatin accessibility and cellular senescence via TP53.

Autor: Lee JD; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. Electronic address: jdlee@post.harvard.edu., Menasche BL; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA., Mavrikaki M; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Uyemura MM; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Hong SM; Department of Genetics, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Kozlova N; Department of Genetics, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Wei J; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA., Alfajaro MM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA., Filler RB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA., Müller A; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Saxena T; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Posey RR; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA., Cheung P; Stem Cell Program, Boston Children's Hospital, Boston, MA 02115, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA., Muranen T; Department of Genetics, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Heng YJ; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA., Paulo JA; Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA., Wilen CB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT 06520, USA; Department of Immunobiology, Yale School of Medicine, New Haven, CT 06520, USA., Slack FJ; Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; Department of Genetics, Cancer Research Institute, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA; Harvard Medical School Initiative for RNA Medicine, Harvard Medical School, Boston, MA 02115, USA. Electronic address: fslack@bidmc.harvard.edu.

Publikováno v: Cell reports [Cell Rep] 2023 Dec 26; Vol. 42 (12), pp. 113478. Date of Electronic Publication: 2023 Nov 21.

Murine Norovirus: Additional Protocols for Basic and Antiviral Studies.

Autor: Wobus CE; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan., Peiper AM; Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida., McSweeney AM; Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand., Young VL; Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand., Chaika M; Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany., Lane MS; Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany., Lingemann M; Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany., Deerain JM; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia., Strine MS; Departments of Immunobiology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut., Alfajaro MM; Departments of Immunobiology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut., Helm EW; Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida., Karst SM; Department of Molecular Genetics & Microbiology, University of Florida, Gainesville, Florida., Mackenzie JM; Department of Microbiology and Immunology, University of Melbourne, Melbourne, Australia., Taube S; Institute of Virology and Cell Biology, University of Lübeck, Lübeck, Germany., Ward VK; Department of Microbiology & Immunology, University of Otago, Dunedin, New Zealand., Wilen CB; Departments of Immunobiology and Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut.

Publikováno v: Current protocols [Curr Protoc] 2023 Jul; Vol. 3 (7), pp. e828.

Pharmacological disruption of mSWI/SNF complex activity restricts SARS-CoV-2 infection.

Autor: Wei J; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Patil A; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Program in Virology, Harvard Medical School, Boston, MA, USA., Collings CK; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA.; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Alfajaro MM; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Liang Y; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Cai WL; Hillman Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA, USA., Strine MS; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Filler RB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., DeWeirdt PC; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Hanna RE; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Menasche BL; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Ökten A; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Peña-Hernández MA; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Klein J; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., McNamara A; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA., Rosales R; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., McGovern BL; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Luis Rodriguez M; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., García-Sastre A; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Division of Infectious Diseases, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Pathology, Molecular and Cell based Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA., White KM; Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Global Health Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Qin Y; Huffington Center for Cell-based Research in Parkinson's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Doench JG; Genetic Perturbation Platform, Broad Institute of MIT and Harvard, Cambridge, MA, USA., Yan Q; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA., Iwasaki A; Department of Pathology, Yale School of Medicine, New Haven, CT, USA.; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA.; Howard Hughes Medical Institute, Chevy Chase, MD, USA., Zwaka TP; Huffington Center for Cell-based Research in Parkinson's Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Department of Cell, Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.; Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Qi J; Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.; Department of Medicine, Harvard Medical School, Boston, MA, USA., Kadoch C; Department of Pediatric Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, USA. cigall_kadoch@dfci.harvard.edu.; Broad Institute of MIT and Harvard, Cambridge, MA, USA. cigall_kadoch@dfci.harvard.edu.; Howard Hughes Medical Institute, Chevy Chase, MD, USA. cigall_kadoch@dfci.harvard.edu., Wilen CB; Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT, USA. craig.wilen@yale.edu.; Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA. craig.wilen@yale.edu.; Yale Cancer Center, Yale School of Medicine, New Haven, CT, USA. craig.wilen@yale.edu.

Publikováno v: Nature genetics [Nat Genet] 2023 Mar; Vol. 55 (3), pp. 471-483. Date of Electronic Publication: 2023 Mar 09.