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of 2
pro vyhledávání: '"Alf Henrik Engman"'
Autor:
Yuri Frosi, Yen-Chu Lin, Jiang Shimin, Siti Radhiah Ramlan, Kelly Hew, Alf Henrik Engman, Anil Pillai, Kit Yeung, Yue Xiang Cheng, Tobias Cornvik, Par Nordlund, Megan Goh, Dilraj Lama, Zachary P. Gates, Chandra S. Verma, Dawn Thean, David P. Lane, Ignacio Asial, Christopher J. Brown
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)
Approaches have been devised to increase the discovery rate of intrabodies but often these yield results that aren’t functional in cells. Here the authors engineer and optimise an autonomous and disulphide-free human VH domain for intracellular exp
Externí odkaz:
https://doaj.org/article/e93e759ee68a4352930b901a4ebc4c2b
Autor:
Yuri Frosi, Shimin Jiang, Siti Radhiah Ramlan, Kelly Hew Hew, Alf Henrik Engman, Anil Pillai, Yue Xiang Cheng, Tobias Cornvik, Pär Nordlund, Megan Goh, Dilraj Lama, Chandra S Verma, Dawn Thean Thean, David P Lane, Ignacio Asial, Christopher Brown
An attractive approach to target intracellular macromolecular interfaces is to design small high affinity proteins. In this manuscript a stable, autonomous, human derived non-immunogenic, disulphide-free VH domain, has been engineered for intracellul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f80d30117a302deec2afff7f0e3fc6c
https://doi.org/10.21203/rs.3.rs-244469/v2
https://doi.org/10.21203/rs.3.rs-244469/v2
