Výsledky vyhledávání - "Alf Beckmann"

The Caveolin-3 G56S sequence variant of unknown significance: Muscle biopsy findings and functional cell biological analysis

Autor: René P. Zahedi, Wolfram Kress, Andreas Roos, Nilane Mohanadas, Hartmut Bauer, Eva Brauers, Stéphanie Thoma, Laxmikanth Kollipara, Joachim Weis, Martin Häusler, Jan Senderek, Alf Beckmann

Publikováno v: Proteomics. Clinical Applications
Proteomics / Clinical applications 11(1/2), 1600007 (2017). doi:10.1002/prca.201600007

Proteomics / Clinical applications 11(1/2), 1600007 (2017). doi:10.1002/prca.201600007
Published by Wiley VCH, Weinheim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0290a2655f9a24c20fe796f286b941d1

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Complementation of non-tumorigenicity of HPV18-positive cervical carcinoma cells involves differential mRNA expression of cellular genes including potential tumor suppressor genes on chromosome 11q13

Autor: Regina Boger, Kerstin Kleine-Lowinski, Ludger Klein-Hitpass, Ha Truong, Alf Beckmann, Ulrich Pascheberg, Antje Repenning, Bertram Opalka, Angela Kehrmann

Publikováno v: Cancer Genetics. 206:279-292

The fusion between human tumorigenic cells and normal human diploid fibroblasts results in non-tumorigenic hybrid cells, suggesting a dominant role for tumor suppressor genes in the generated hybrid cells. After long-term cultivation in vitro, tumori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fbb6fd8797724a6d81d67ee83b2d021e
https://doi.org/10.1016/j.cancergen.2013.06.002

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Gain-of-Function Mutations in TRPM4 Cause Autosomal Dominant Isolated Cardiac Conduction Disease

Autor: Olaf Pongs, Gerard Blaysat, Romain Guinamard, André Mégarbané, Andre Bozio, Hui Liu, Elisabeth Villain, Martin Kruse, Alf Beckmann, Gueven Kurtbay, Loubna El Zein, Iris Ohmert, Patrice Bouvagnet

Publikováno v: Circulation: Cardiovascular Genetics. 3:374-385

Background— Isolated cardiac conduction block is a relatively common condition in young and elderly populations. Genetic predisposing factors have long been suspected because of numerous familial case reports. Deciphering genetic predisposing facto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcbab68a18cb4d76b02378f6bc680ca4
https://doi.org/10.1161/circgenetics.109.930867

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Blood-Borne Cancer Cells – Quo Vadis?

Autor: Burkhard Brandt, Feldner Jc, H. Schmitt, Ralph J. Lellé, Alf Beckmann, Axel Semjonow

Publikováno v: Scopus-Elsevier

The detection of blood-borne cancer cells may help in clinical staging and further understanding of cancer metastasis. We developed a cytokeratin-based immunomagnetic method to isolate epithelium-derived cells from the circulating blood of patients.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17a71d13fb756e0b9ebd45c1c0e5d514
https://doi.org/10.1177/172460080001500121

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Impaired endocytosis of the ion channel TRPM4 is associated with human progressive familial heart block type I

Autor: Iris Ohmert, Paul A. Brink, Olaf Pongs, Eric Schulze-Bahr, Valerie A. Corfield, Alf Beckmann, Guven Kurtbay, Martin Kruse, Birgit Stallmeyer, E. Schulze-Bahr

Publikováno v: The Journal of clinical investigation. 119(9)

Progressive familial heart block type I (PFHBI) is a progressive cardiac bundle branch disease in the His-Purkinje system that exhibits autosomal-dominant inheritance. In 3 branches of a large South African Afrikaner pedigree with an autosomal-domina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23aeae652bdb0f71da32e6817aead60a
https://pubmed.ncbi.nlm.nih.gov/20095982

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Double- and Competitive-Differential PCR for Gene Dosage Quantitation

Autor: Alf Beckmann, Antje Roetger, Burkhard Brandt, Frank Gebhardt

An association of a loss of DNA replication control and the activation of erbB oncogenes can be deduced from studies with different cancers (1-5). In the first study on ovarian cancer 26% of the tumors had c-erbB-2 amplifications (6). The correlation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::090c9d009cb29e0b5b067231f369c6d6
https://doi.org/10.1385/1-59259-071-3:347

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Direct quantification of polymerase chain reaction fragments using field-amplified sample injection in capillary zone electrophoresis for gene dosage estimation

Autor: Alf Beckmann, Frank Gebhardt, Burkhard Brandt

Publikováno v: Journal of chromatography. B, Biomedical sciences and applications. 710(1-2)

To assess gene dosages for clinical application, especially for prognostication of cancer, we developed a direct quantification method for polymerase chain reaction products. We report on an application of field amplified sample injection (FASI) to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5490b75fd170ec41c1b796bc88818c97
https://pubmed.ncbi.nlm.nih.gov/9686873

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Translational research studies of erbB oncogenes: selection strategies for breast cancer treatment

Autor: Alf Beckmann, Gerd Assmann, Kurt S. Zänker, Burkhard Brandt, Christian Jackisch, Frank Gebhardt, Antje Rötger

Publikováno v: Cancer letters. 118(2)

Specific gene families, e.g. encoding members of signal transduction pathways, show a gene dosage sensitivity. We report on the determination of the gene dosages of egfr and c-erbB-2 in relation to the intratumoral concentration of the tyrosine kinas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad99662dc5674a0810d9f822f458b65f
https://pubmed.ncbi.nlm.nih.gov/9459204

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Direct-double-differential PCR for gene dosage quantification of c-myc

Autor: U. Vogt, Burkhard Brandt, Alf Beckmann, Norbert Huda, Kurt S. Zänker

Publikováno v: Scopus-Elsevier

c- myc gene amplification that leads to overexpression has been shown to play a major role in cancer development, especially in breast cancer (1). Two methodological approaches based on PCR, differential PCR (2) and competitive PCR (3), have been dev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::504539f5cf8e8c9cb0f4da5953a85280
http://www.scopus.com/inward/record.url?eid=2-s2.0-0032899324&partnerID=MN8TOARS

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