Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexya N. Aguilera"'
Autor:
Eileen A. Moran, Karen Salas-Briceno, Wenming Zhao, Takuji Enya, Alexya N. Aguilera, Ivan Acosta, Francis Alonzo, Dara Kiani, Judith Behnsen, Catalina Alvarez, Thomas M. Keane, David J. Adams, Jingtao Lilue, Susan R. Ross
Publikováno v:
mBio, Vol 15, Iss 7 (2024)
ABSTRACT Mammalian AIM-2-like receptor (ALR) proteins bind nucleic acids and initiate production of type I interferons or inflammasome assembly, thereby contributing to host innate immunity. In mice, the Alr locus is highly polymorphic at the sequenc
Externí odkaz:
https://doaj.org/article/dc580ccc007e4157abcf0818a77211f2
Publikováno v:
mBio, Vol 9, Iss 3 (2018)
ABSTRACT Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of virus. Retrovirus reverse transcription creates numerous potential ligands for cytosolic hos
Externí odkaz:
https://doaj.org/article/2aea56d3644c4e3a806aa62489105a5c
Autor:
Ravi Shankar Singh, Venkatasubramanian Vidhyasagar, Shizhuo Yang, Ananna Bhadra Arna, Manisha Yadav, Aanchal Aggarwal, Alexya N. Aguilera, Satoru Shinriki, Kalpana Kalyanasundaram Bhanumathy, Kannupriya Pandey, Aizhang Xu, Noreen Rapin, Mark Bosch, John DeCoteau, Jim Xiang, Franco J. Vizeacoumar, Yan Zhou, Vikram Misra, Hirotaka Matsui, Susan R. Ross, Yuliang Wu
Publikováno v:
Cell reports. 39(8)
Upon binding double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) is activated and initiates the cGAS-stimulator of IFN genes (STING)-type I interferon pathway. DEAD-box helicase 41 (DDX41) is a DEAD-box helicase, and mutations in DDX41 cause
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c746d1309abbc99b99c05dfd23828d
https://pubmed.ncbi.nlm.nih.gov/35613581
https://pubmed.ncbi.nlm.nih.gov/35613581
Autor:
Yuliang Wu, Hirotaka Matsui, Alexya N. Aguilera, Jim Xiang, Manisha Yadav, John F. DeCoteau, Shizhuo Yang, Vikram Misra, Ananna Bhadra Arna, Yan Zhou, Susan R. Ross, Aanchal Aggarwal, Franco J. Vizeacoumar, Kalpana Kalyanasundaram Bhanumathy, Satoru Shinriki, Venkatasubramanian Vidhyasagar, Noreen Rapin, Aizhang Xu, Mark Bosch, Kannupriya Pandey, Ravi Shankar Singh
Publikováno v:
SSRN Electronic Journal.
Upon binding double-stranded (ds)DNA, cGAS is activated and initiates the cGAS-STING-type I interferon pathway; thus, the availability of dsDNA ligand is critical for cGAS activation. DDX41 is a DEAD-box helicase and mutations in DDX41 cause myelodys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7eeee546a749ae16eae4f9539b09631e
https://doi.org/10.2139/ssrn.3866840
https://doi.org/10.2139/ssrn.3866840
Autor:
Gabriel J. Starrett, Timothy K. Starr, Sandra Wagner, David A. Largaespada, Emily K. Law, Alexya N. Aguilera, Michael A. Carpenter, Michael B. Burns, Susan R. Ross, Hyoung Kim, Nuri A. Temiz, Lindsay K. Larson, Prokopios P. Argyris, Cameron Durfee, Rachel Isaksson Vogel, Rena Levin-Klein, Reuben S. Harris, Matthew C. Jarvis, Spyridon Stavrou
Publikováno v:
The Journal of Experimental Medicine
The APOBEC mutation signature is abundant in cancer, but its relationship to the multistep process of carcinogenesis is unclear. Studies by Law and colleagues demonstrate that APOBEC3A catalyzes mutagenesis and promotes tumorigenesis in two different
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9ba8178c2d5f053876081e771c5144c
https://pubmed.ncbi.nlm.nih.gov/32870257
https://pubmed.ncbi.nlm.nih.gov/32870257
Autor:
Matthew C. Jarvis, Michael A. Carpenter, Prokopios P. Argyris, Reuben S. Harris, Susan R. Ross, Hyoung Kim, Rachel Isaksson Vogel, Spyridon Stavrou, Gabriel J. Starrett, Rena Levin-Klein, Lindsay K. Larson, Sandra Wagner, David A. Largaespada, Emily K. Law, Timothy K. Starr, Alexya N. Aguilera, Michael B. Burns
SUMMARYThe APOBEC3 family of antiviral DNA cytosine deaminases is implicated as the second largest source of mutation in cancer. This mutational process may be a causal driver or inconsequential passenger to the overall tumor phenotype. We show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cbdf24db5665378ad4d0283718511e
https://doi.org/10.1101/2019.12.27.889345
https://doi.org/10.1101/2019.12.27.889345
Publikováno v:
mBio, Vol 9, Iss 3, p e00923-18 (2018)
mBio, Vol 9, Iss 3 (2018)
mBio, Vol 9, Iss 3 (2018)
Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of virus. Retrovirus reverse transcription creates numerous potential ligands for cytosolic host sensors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fd8a38ed888f89aeb8ea350a9496aba
https://doaj.org/article/bc3607cd7a9249b198b87317b2aee08b
https://doaj.org/article/bc3607cd7a9249b198b87317b2aee08b
Host recognition of viral nucleic acids generated during infection leads to the activation of innate immune responses essential for early control of virus. Retrovirus reverse transcription creates numerous potential ligands for cytosolic host sensors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babe1062b7f82068723dd535696eb0d7
Publikováno v:
The Journal of Immunology. 198:215.8-215.8
The ability of long-lived plasma cells (LLPC) to maintain longevity and avoid metabolic burnout has been largely unexplored until recently. Our lab has shown that LLPC reside in hypoxic niches and are divided into two distinct subsets based on fluore
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e25d2603a153b4e13601912b8cbe84fc
https://doi.org/10.4049/jimmunol.198.supp.215.8
https://doi.org/10.4049/jimmunol.198.supp.215.8
Publikováno v:
The Journal of Immunology. 196:204.27-204.27
The metabolic stress of being an antibody-secreting cell is likely great. Indeed, existing literature suggests short-lived plasma cells (SLPC) die due to high metabolic stress. How long-lived (LL) PC maintain longevity and escape the same fate as SLP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d471f381573b6b597ce0aa6e61e588d5
https://doi.org/10.4049/jimmunol.196.supp.204.27
https://doi.org/10.4049/jimmunol.196.supp.204.27