Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexy Promonet"'
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/8da2ac3ab80149858da4db0c6e7c1c9d
Autor:
Alexy Promonet, Ismaël Padioleau, Yaqun Liu, Lionel Sanz, Anna Biernacka, Anne-Lyne Schmitz, Magdalena Skrzypczak, Amélie Sarrazin, Clément Mettling, Maga Rowicka, Krzysztof Ginalski, Frédéric Chedin, Chun-Long Chen, Yea-Lih Lin, Philippe Pasero
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
While R-loops can alter cell homeostasis, it is unclear what determines their toxicity. Here, the authors, by using Top1 knockdown as a tool to enhance the formation of R-loops at certain genomic sites, reveal and characterize a proportion of R-loops
Externí odkaz:
https://doaj.org/article/bd1932962b864455ac3b032015f1a0ac
Autor:
Serge Urbach, Jihane Basbous, Alexy Promonet, Sophie Vidal-Eychenie, Marie Lamarque, Marie-Pierre Blanchard, Camilla Frattini, Angelos Constantinou, Emile Alghoul
Publikováno v:
Molecular Cell
Molecular Cell, Elsevier, 2021, 81 (6), pp.1231-1245.e8. ⟨10.1016/j.molcel.2020.12.049⟩
Molecular Cell, 2021, 81 (6), pp.1231-1245.e8. ⟨10.1016/j.molcel.2020.12.049⟩
Molecular Cell, Elsevier, 2021, 81 (6), pp.1231-1245.e8. ⟨10.1016/j.molcel.2020.12.049⟩
Molecular Cell, 2021, 81 (6), pp.1231-1245.e8. ⟨10.1016/j.molcel.2020.12.049⟩
ATR checkpoint signalling is crucial for cellular responses to DNA replication impediments. Using an optogenetic platform, we show that TopBP1, the main activator of ATR, self-assembles extensively to yield micron-sized condensates. These opto-TopBP1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33ca88637e89cf4409a7f4466414eb99
https://hal.archives-ouvertes.fr/hal-03367743
https://hal.archives-ouvertes.fr/hal-03367743
Autor:
Anna Biernacka, Philippe Pasero, Chun-Long Chen, Maga Rowicka, Krzysztof Ginalski, Ismael Padioleau, Lionel A. Sanz, Frédéric Chédin, Yaqun Liu, Magdalena Skrzypczak, Clément Mettling, Amélie Sarrazin, Anne Lyne Schmitz, Alexy Promonet, Yea-Lih Lin
Publikováno v:
Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17858-2⟩
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Nature Communications, Nature Publishing Group, 2020, 11 (1), ⟨10.1038/s41467-020-17858-2⟩
Nature communications, vol 11, iss 1
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
R-loops have both positive and negative impacts on chromosome functions. To identify toxic R-loops in the human genome, here, we map RNA:DNA hybrids, replication stress markers and DNA double-strand breaks (DSBs) in cells depleted for Topoisomerase I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22bb0401ad666a4691957839a93ebf5
https://doi.org/10.1038/s41467-020-17858-2
https://doi.org/10.1038/s41467-020-17858-2
Autor:
Yea-Lih Lin, Vincenzo Costanzo, Karina Zadorozhny, Anne-Lyne Schmitz, Flavie Coquel, Alexandra Cribier, Maria Joao Silva, Philippe Pasero, Bernard S. Lopez, Hervé Técher, Clément Mettling, Amélie Sarrazin, Antoine Barthe, Andrei Chabes, Elodie Dardillac, Jadwiga Nieminuszczy, Monsef Benkirane, Alexy Promonet, L. Krejci, Wojciech Niedzwiedz, Sushma Sharma
Publikováno v:
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
International audience; DNA replication is an extremely complex process, involving thousands of replication forks progressing along chromosomes. These forks are requently slowed down or stopped by various obstacles, such as secondary DNA structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d55e0061a47b221acde166cb0f1fb4
https://hal.archives-ouvertes.fr/hal-03083188/document
https://hal.archives-ouvertes.fr/hal-03083188/document
Autor:
Philippe Pasero, Maria-Joao Silva, Anne-Lyne Schmitz, Alexandra Cribier, Hervé Técher, Amélie Sarrazin, Elodie Dardillac, Clément Mettling, Antoine Barthe, Jadwiga Nieminuszczy, Bernard S. Lopez, Andrei Chabes, Yea-Lih Lin, Flavie Coquel, Lumir Krejci, Sushma Sharma, Vincenzo Costanzo, Karina Zadorozhny, Wojciech Niedzwiedz, Monsef Benkirane, Alexy Promonet
Publikováno v:
Nature
Nature, Nature Publishing Group, 2018, 557 (7703), pp.57-61. ⟨10.1038/s41586-018-0050-1⟩
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
Nature, Nature Publishing Group, 2018, 557 (7703), pp.57-61. ⟨10.1038/s41586-018-0050-1⟩
Comptes Rendus Biologies
Comptes Rendus Biologies, Elsevier, 2020, 343 (1), pp.9-21. ⟨10.5802/crbiol.10⟩
International audience; DNA replication is an extremely complex process, involving thousands of replication forks progressing along chromosomes. These forks are requently slowed down or stopped by various obstacles, such as secondary DNA structures,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdceae5a70236e3ddce41e110a40ce9
https://hal.archives-ouvertes.fr/hal-01791237
https://hal.archives-ouvertes.fr/hal-01791237