Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice.

Autor: Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Dai Y; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Vancuylenburg CS; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Santiago-Rivera JA; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Philp AM; St Vincent's Clinical School, UNSW Medicine, University of New South Wales, Sydney, New South Wales, Australia., Hargett SR; Department of Pharmacology, University of Virginia, Charlottesville, VA., Li K; Department of Pharmacology, University of Virginia, Charlottesville, VA., Shah DP; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Chen SY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Li C; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Harris TE; Department of Pharmacology, University of Virginia, Charlottesville, VA., Lee B; Biological Resources Imaging Laboratory, University of New South Wales, Sydney, New South Wales, Australia., Wathier M; Life Biosciences, Boston, MA., Cermak JM; Life Biosciences, Boston, MA., Tucker SP; Life Biosciences, Boston, MA.; Firebrick Pharma, Melbourne, Victoria, Australia., Turner N; Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, New South Wales, Australia., Bayliss DA; Department of Pharmacology, University of Virginia, Charlottesville, VA., Philp A; Centre for Healthy Ageing, Centenary Institute, Camperdown, New South Wales, Australia.; School of Sport, Exercise and Rehabilitation Sciences, University of Technology Sydney, Sydney, New South Wales, Australia.; Charles Perkins Centre, The University of Sydney, Camperdown, New South Wales, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia., Santos WL; Department of Chemistry and Virginia Tech Center for Drug Discovery, Virginia Tech, Blacksburg, VA., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Kensington, New South Wales, Australia.; Department of Pharmacology, University of Virginia, Charlottesville, VA.

Publikováno v: Diabetes [Diabetes] 2024 Mar 01; Vol. 73 (3), pp. 374-384.

Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice.

Autor: Chen SY; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Shah DP; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Byrne FL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia., Salamoun JM; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Garcia CJ; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Smith GC; School of Medical Science, University of New South Wales, Sydney, NSW 2052, Australia., Larance M; Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia., Philp A; Charles Perkins Centre, School of Medical Sciences, The University of Sydney, Sydney, NSW 2006, Australia; Centre for Healthy Ageing, Centenary Institute, Camperdown, NSW 2050, Australia; School of Sport, Exercise and Rehabilitation Sciences, Faculty of Health, University of Technology Sydney, Sydney, NSW 2007, Australia., Turner N; Cellular Bioenergetics Laboratory, Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia., Santos WL; Department of Chemistry and Virginia Tech Centre for Drug Discovery, Virginia Tech, Blacksburg, VA 24061, USA., Cantley J; School of Medicine, University of Dundee, Dundee DD1 4HN, UK., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia. Electronic address: k.hoehn@unsw.edu.au.

Publikováno v: Biochimica et biophysica acta. Molecular basis of disease [Biochim Biophys Acta Mol Basis Dis] 2024 Jan; Vol. 1870 (1), pp. 166908. Date of Electronic Publication: 2023 Oct 02.

Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15.

Autor: Zunica ERM; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44109, USA.; Clinical Oncology and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Axelrod CL; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Cho E; School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA., Spielmann G; School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA., Davuluri G; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Sarcopenia and Malnutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, 2052, Australia., Beretta M; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, 2052, Australia., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales, 2052, Australia., Dantas WS; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA., Stadler K; Department of Oxidative Stress and Disease, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., King WT; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Pergola K; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Irving BA; School of Kinesiology, Louisiana State University, Baton Rouge, LA, USA., Langohr IM; Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, 70803, USA., Yang S; Department of Biostatistics, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA., Hoppel CL; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, 44109, USA., Gilmore LA; Clinical Oncology and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA.; Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas, TX, 75390, USA., Kirwan JP; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA, 70808, USA. john.kirwan@pbrc.edu.; Department of Nutrition, Case Western Reserve University, Cleveland, OH, 44109, USA. john.kirwan@pbrc.edu.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, 70808, USA. john.kirwan@pbrc.edu.

Publikováno v: Cancer & metabolism [Cancer Metab] 2021 Oct 09; Vol. 9 (1), pp. 36. Date of Electronic Publication: 2021 Oct 09.

BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control.

Autor: Axelrod CL; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., King WT; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Davuluri G; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Sarcopenia and Malnutrition Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Noland RC; Skeletal Muscle Metabolism Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Hall J; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Hull M; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Dantas WS; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Zunica ER; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Hoehn KL; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia., Langohr I; Department of Pathobiological Sciences, Louisiana State University, Baton Rouge, LA, USA., Stadler K; Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Doyle H; Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Schmidt E; Oxidative Stress and Disease Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Nieuwoudt S; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Fitzgerald K; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Pergola K; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Translational Services, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Fujioka H; Cryo-Electron Microscopy Core, Case Western Reserve University, Cleveland, OH, USA., Mey JT; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Fealy C; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Mulya A; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA., Beyl R; Department of Biostatistics, Pennington Biomedical Research Center, Baton Rouge, LA, USA., Hoppel CL; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Pharmacology, Case Western Reserve University, Cleveland, OH, USA., Kirwan JP; Integrated Physiology and Molecular Medicine Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA.; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA.; Department of Nutrition, Case Western Reserve University, Cleveland, OH, USA.

Publikováno v: EMBO molecular medicine [EMBO Mol Med] 2020 Jul 07; Vol. 12 (7), pp. e12088. Date of Electronic Publication: 2020 Jun 10.

Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3).

Autor: Knights AJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Vohralik EJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Houweling PJ; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC, 3052, Australia., Stout ES; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Norton LJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Alexopoulos SJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Yik JJ; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Mat Jusoh H; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia., Olzomer EM; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Bell-Anderson KS; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, 2006, Australia., North KN; Murdoch Children's Research Institute, The Royal Children's Hospital, Melbourne, VIC, 3052, Australia.; Department of Paediatrics, University of Melbourne, Melbourne, VIC, 3052, Australia., Hoehn KL; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Crossley M; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia., Quinlan KGR; School of Biotechnology and Biomolecular Sciences, UNSW Sydney, Sydney, NSW, 2052, Australia. kate.quinlan@unsw.edu.au.

Publikováno v: Nature communications [Nat Commun] 2020 Jun 10; Vol. 11 (1), pp. 2922. Date of Electronic Publication: 2020 Jun 10.