The neuropeptidergic connectome ofC. elegans

Autor: Lidia Ripoll-Sánchez, Jan Watteyne, HaoSheng Sun, Robert Fernandez, Seth R Taylor, Alexis Weinreb, Mark Hammarlund, David M Miller, Oliver Hobert, Isabel Beets, Petra E Vértes, William R Schafer

SummaryEfforts are currently ongoing to map synaptic wiring diagrams or connectomes in order to understand the neural basis of brain function. However, chemical synapses represent only one type of functionally important neuronal connection; in partic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36bdcc3c8c907faa314f04386a844624
https://doi.org/10.1101/2022.10.30.514396

A head-to-head comparison of ribodepletion and polyA selection approaches for Caenorhabditis elegans low input RNA-sequencing libraries

Autor: Seth R. Taylor, David M. Miller, Marc Hammarlund, Rebecca McWhirter, Alec Barrett, Alexis Weinreb

Publikováno v: G3: Genes|Genomes|Genetics

A recent and powerful technique is to obtain transcriptomes from rare cell populations, such as single neurons in Caenorhabditis elegans, by enriching dissociated cells using fluorescent sorting. However, these cell samples often have low yields of R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3151345c402dc3702bda694e6364135e
https://doi.org/10.1093/g3journal/jkab121

Molecular topography of an entire nervous system

Autor: Molly B. Reilly, Cyril Cros, Marc Hammarlund, Seth R. Taylor, Alec Barrett, Gabriel Santpere, Saeed Tavazoie, Alexander J. Abrams, Abigail Poff, Lori Glenwinkel, Manasa Basavaraju, Oliver Hobert, Chuan Xu, Erdem Varol, David M. Miller, Eviatar Yemini, Rebecca McWhirter, Panos Oikonomou, Nenad Sestan, Berta Vidal, Ibnul Rafi, Steven J. Cook, Alexis Weinreb

SummaryNervous systems are constructed from a deep repertoire of neuron types but the underlying gene expression programs that specify individual neuron identities are poorly understood. To address this deficit, we have produced an expression profile

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::178dcc6aa3d8f653a5c599e913d3eb51
https://doi.org/10.1101/2020.12.15.422897

Expression profiling of the mature C. elegans nervous system by single-cell RNA-Sequencing

Autor: Steven J. Cook, Chuan Xu, David M. Miller, Manasa Basavaraju, Nenad Sestan, Seth R. Taylor, Oliver Hobert, Gabriel Santpere, Molly B. Reilly, Lori Glenwinkel, Alec Barrett, Alexander J. Abrams, Rebecca McWhirter, Marc Hammarlund, Berta Vidal, Cyril Cros, Ibnul Rafi, Alexis Weinreb, Abigail Poff

A single neuron and its synapses define the fundamental structural motif of the brain but the underlying gene expression programs that specify individual neuron types are poorly understood. To address this question in a model organism, we have produc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::646fb7edfb9daeb903b0441cefcb63c2
https://doi.org/10.1101/737577

The netrin receptor UNC-40/DCC assembles a postsynaptic scaffold and sets the synaptic content of GABAA receptors

Autor: Zhou, Xin, Gueydan, Marine, Jospin, Maelle, Ji, Tingting, Valfort, Aurore, Pinan-Lucarré, Bérangère, Bessereau, Jean-Louis

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.2674. ⟨10.1038/s41467-020-16473-5⟩
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 2020, 11 (1), pp.2674. ⟨10.1038/s41467-020-16473-5⟩

Increasing evidence indicates that guidance molecules used during development for cellular and axonal navigation also play roles in synapse maturation and homeostasis. In C. elegans the netrin receptor UNC-40/DCC controls the growth of dendritic-like

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::5b6b907f8e39f2f2d163e6d6d1f4527d
https://www.hal.inserm.fr/inserm-02879833/file/s41467-020-16473-5.pdf