Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexis Vedder"'
Autor:
Amy F. McLemore, Hsin-An Hou, Benjamin S. Meyer, Nghi B. Lam, Grace A. Ward, Amy L. Aldrich, Matthew A. Rodrigues, Alexis Vedder, Ling Zhang, Eric Padron, Nicole D. Vincelette, David A. Sallman, Omar Abdel-Wahab, Alan F. List, Kathy L. McGraw
Publikováno v:
JCI Insight, Vol 7, Iss 15 (2022)
NLRP3 inflammasome and IFN-stimulated gene (ISG) induction are key biological drivers of ineffective hematopoiesis and inflammation in myelodysplastic syndromes (MDSs). Gene mutations involving mRNA splicing and epigenetic regulatory pathways induce
Externí odkaz:
https://doaj.org/article/488f4e3ab6114c1b8723eabf8f2131c9
Autor:
Ryan M. Carr, Denis Vorobyev, Terra Lasho, David L. Marks, Ezequiel J. Tolosa, Alexis Vedder, Luciana L. Almada, Andrey Yurcheko, Ismael Padioleau, Bonnie Alver, Giacomo Coltro, Moritz Binder, Stephanie L. Safgren, Isaac Horn, Xiaona You, Eric Solary, Maria E. Balasis, Kurt Berger, James Hiebert, Thomas Witzig, Ajinkya Buradkar, Temeida Graf, Peter Valent, Abhishek A. Mangaonkar, Keith D. Robertson, Matthew T. Howard, Scott H. Kaufmann, Christopher Pin, Martin E. Fernandez-Zapico, Klaus Geissler, Nathalie Droin, Eric Padron, Jing Zhang, Sergey Nikolaev, Mrinal M. Patnaik
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these
Externí odkaz:
https://doaj.org/article/76c77b395be34b1d8dcd36a45fbde44e
Autor:
Christopher T. Letson, Maria E. Balasis, Hannah Newman, Moritz Binder, Alexis Vedder, Fumi Kinose, Markus Ball, Traci Kruer, Ariel Quintana, Terra L. Lasho, Christy M. Finke, Luciana L. Almada, Jennifer M. Grants, Guolin Zhang, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Jeffrey Lancet, Rami Komrokji, Eric Haura, David A. Sallman, Gary W. Reuther, Aly Karsan, Uwe Rix, Mrinal M. Patnaik, Eric Padron
Publikováno v:
Clinical Cancer Research.
Background: Preclinical studies in myeloid neoplasms have demonstrated efficacy of Bromodomain and Extra-Terminal protein inhibitors (BETi). However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9f2ab28b9cd1f3f86e4470ee6f5b0a1f
https://doi.org/10.1158/1078-0432.ccr-22-3929
https://doi.org/10.1158/1078-0432.ccr-22-3929
Autor:
Nana Adjoa Ben-Crentsil, Ariel Quintana-Gonzalez, Maria E Balasis, Hannah Newman, Traci L. Kruer, Lei Sun, Christopher Letson, Abhishek Dhawan, Chetasi Talati, Meghan Ferrall-Fairbanks, Alexis Vedder, Kathy McGraw, Rami S. Komrokji, Li Ma, Eric Padron
Publikováno v:
Blood. 140:1991-1993
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb98cb5b48226a5f4c97ca5b26f44cb
https://doi.org/10.1182/blood-2022-156670
https://doi.org/10.1182/blood-2022-156670
Autor:
Ross L. Levine, Jing Zhang, Fabao Liu, Alexis Vedder, Xin Gao, Sergey Nikolaev, Mrinal M. Patnaik, Abhishek A. Mangaonkar, Yun Zhou, Kalyan Vara Ganesh Nadiminti, Anthony M. Hunter, Terra L. Lasho, Wei Xu, Evan Flietner, Erik A. Ranheim, Xiaona You, Ruiqi Liao, Klaus Geissler, Eric Padron, Nathalie Droin, Guangyao Kong, Moritz Binder, Eric Solary, Maria E. Balasis, Christy Finke, Britta Will, Omar Abdel-Wahab, Adhithi Rajagopalan, Zhi Wen, David T. Yang
Publikováno v:
Blood
Mutations in chromatin regulator ASXL1 are frequently identified in myeloid malignancies, in particular ∼40% of patients with chronic myelomonocytic leukemia (CMML). ASXL1 mutations are associated with poor prognosis in CMML and significantly co-oc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48bb19333aa8d11e90688ba3955306c7
https://doi.org/10.1182/blood.2021012519
https://doi.org/10.1182/blood.2021012519
Autor:
Christopher T. Letson, Maria E. Balasis, Hannah Newman, Moritz Binder, Alexis Vedder, Fumi Kinose, Markus Ball, Traci Kruer, Ariel Quintana-Gonzalez, Terra L. Lasho, Christy M. Finke, Luciana L. Almada, Jennifer M. Grants, Guolin Zhang, Martin E. Fernandez-Zapico, Alexandre Gaspar-Maia, Jeffrey Lancet, Rami Komrokji, Eric Haura, Gary W. Reuther, Aly Karsan, Uwe Rix, Mrinal M. Patnaik, Eric Padron
SummaryPreclinical studies in myeloid neoplasms have demonstrated efficacy of Bromodomain and Extra-Terminal protein inhibitors (BETi). However, BETi demonstrate poor single agent activity in clinical trials. Several studies suggest that combination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3603667e963f493dee14fd6d6e4c85b2
https://doi.org/10.1101/2022.11.01.514753
https://doi.org/10.1101/2022.11.01.514753
Autor:
Christina R. Hartigan, Benjamin L. Ebert, Caroline Stanclift, Namrata D. Udeshi, Monica Schenone, Amanuel Bizuayehu, Veronica Kovalcik, Tanya Svinkina, Alexis Vedder, Marie McConkey, Eric Padron, Sebastian Koochaki, Roger Belizaire, Steven A. Carr, Lei Sun
Publikováno v:
Blood
Casitas B-lineage lymphoma (CBL) encodes an E3 ubiquitin ligase and signaling adaptor that regulates receptor and nonreceptor tyrosine kinases. Recurrent CBL mutations occur in myeloid neoplasms, including 10% to 20% of chronic myelomonocytic leukemi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f67f94c5201cac2e768c006d0fdb23
https://doi.org/10.1182/blood.2020006528
https://doi.org/10.1182/blood.2020006528
Autor:
Alexis Vedder, Eric Padron, Natalie H Ragland, Emily L Miedel, Christopher Letson, Robert W. Engelman, Maria E. Balasis
Publikováno v:
Comparative Medicine
Modeling chronic myelomonocytic leukemia (CMML) in immunodeficient NSGS mice relies on unique human CMML specimens and consistent murine engraftment. Only anecdotal comments have thus far supported the notion that research data may be altered by Cory
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e496f7d469c63e373073048b35c4f7
https://doi.org/10.30802/aalas-cm-18-000138
https://doi.org/10.30802/aalas-cm-18-000138
TFEB links MYC signaling to epigenetic control of myeloid differentiation and acute myeloid leukemia
Autor:
Weimin Li, Gregory W Watson, Chia-Ho Cheng, Franz X. Schaub, Audrey R Freischel, Ling Cen, Hsin-An Hou, Seongseok Yun, Daniel J. Murphy, Mario R. Fernandez, Scott H. Kaufmann, Alexis Vedder, Jungwon Moon, Ling Zhang, Xiaoqing Yu, Kathy L. McGraw, Taro Hitosugi, Chunying Yang, Andrea Ballabio, Nicole D. Vincelette, John L. Cleveland, Anders Berglund
Publikováno v:
Blood Cancer Discov
MYC oncoproteins regulate transcription of genes directing cell proliferation, metabolism, and tumorigenesis. A variety of alterations drive MYC expression in acute myeloid leukemia (AML), and enforced MYC expression in hematopoietic progenitors is s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59dc771a9a3643d5f7a10b48a2cd0845
https://europepmc.org/articles/PMC8043621/
https://europepmc.org/articles/PMC8043621/
Autor:
Caroline Stanclift, Roger Belizaire, Tanya Svinkina, Alexis Vedder, Christina R. Hartigan, Steven A. Carr, Sebastian Koochaki, Benjamin L. Ebert, Lei Sun, Monica Schenone, Eric Padron, Namrata D. Udeshi
CBL encodes an E3 ubiquitin ligase and signaling adaptor that acts downstream of cytokine receptors. Recurrent CBL mutations occur in myeloid malignancies, but the mechanism by which these mutations drive oncogenesis remains incompletely understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaeb73dbda9ed918a96fa4fb120ee36c
https://doi.org/10.1101/2020.04.13.038448
https://doi.org/10.1101/2020.04.13.038448