Exome-wide association study to identify rare variants influencing COVID-19 outcomes: Results from the Host Genetics Initiative.

Autor: Guillaume Butler-Laporte, Gundula Povysil, Jack A Kosmicki, Elizabeth T Cirulli, Theodore Drivas, Simone Furini, Chadi Saad, Axel Schmidt, Pawel Olszewski, Urszula Korotko, Mathieu Quinodoz, Elifnaz Çelik, Kousik Kundu, Klaudia Walter, Junghyun Jung, Amy D Stockwell, Laura G Sloofman, Daniel M Jordan, Ryan C Thompson, Diane Del Valle, Nicole Simons, Esther Cheng, Robert Sebra, Eric E Schadt, Seunghee Kim-Schulze, Sacha Gnjatic, Miriam Merad, Joseph D Buxbaum, Noam D Beckmann, Alexander W Charney, Bartlomiej Przychodzen, Timothy Chang, Tess D Pottinger, Ning Shang, Fabian Brand, Francesca Fava, Francesca Mari, Karolina Chwialkowska, Magdalena Niemira, Szymon Pula, J Kenneth Baillie, Alex Stuckey, Antonio Salas, Xabier Bello, Jacobo Pardo-Seco, Alberto Gómez-Carballa, Irene Rivero-Calle, Federico Martinón-Torres, Andrea Ganna, Konrad J Karczewski, Kumar Veerapen, Mathieu Bourgey, Guillaume Bourque, Robert Jm Eveleigh, Vincenzo Forgetta, David Morrison, David Langlais, Mark Lathrop, Vincent Mooser, Tomoko Nakanishi, Robert Frithiof, Michael Hultström, Miklos Lipcsey, Yanara Marincevic-Zuniga, Jessica Nordlund, Kelly M Schiabor Barrett, William Lee, Alexandre Bolze, Simon White, Stephen Riffle, Francisco Tanudjaja, Efren Sandoval, Iva Neveux, Shaun Dabe, Nicolas Casadei, Susanne Motameny, Manal Alaamery, Salam Massadeh, Nora Aljawini, Mansour S Almutairi, Yaseen M Arabi, Saleh A Alqahtani, Fawz S Al Harthi, Amal Almutairi, Fatima Alqubaishi, Sarah Alotaibi, Albandari Binowayn, Ebtehal A Alsolm, Hadeel El Bardisy, Mohammad Fawzy, Fang Cai, Nicole Soranzo, Adam Butterworth, COVID-19 Host Genetics Initiative, DeCOI Host Genetics Group, GEN-COVID Multicenter Study (Italy), Mount Sinai Clinical Intelligence Center, GEN-COVID consortium (Spain), GenOMICC Consortium, Japan COVID-19 Task Force, Regeneron Genetics Center, Daniel H Geschwind, Stephanie Arteaga, Alexis Stephens, Manish J Butte, Paul C Boutros, Takafumi N Yamaguchi, Shu Tao, Stefan Eng, Timothy Sanders, Paul J Tung, Michael E Broudy, Yu Pan, Alfredo Gonzalez, Nikhil Chavan, Ruth Johnson, Bogdan Pasaniuc, Brian Yaspan, Sandra Smieszek, Carlo Rivolta, Stephanie Bibert, Pierre-Yves Bochud, Maciej Dabrowski, Pawel Zawadzki, Mateusz Sypniewski, Elżbieta Kaja, Pajaree Chariyavilaskul, Voraphoj Nilaratanakul, Nattiya Hirankarn, Vorasuk Shotelersuk, Monnat Pongpanich, Chureerat Phokaew, Wanna Chetruengchai, Katsushi Tokunaga, Masaya Sugiyama, Yosuke Kawai, Takanori Hasegawa, Tatsuhiko Naito, Ho Namkoong, Ryuya Edahiro, Akinori Kimura, Seishi Ogawa, Takanori Kanai, Koichi Fukunaga, Yukinori Okada, Seiya Imoto, Satoru Miyano, Serghei Mangul, Malak S Abedalthagafi, Hugo Zeberg, Joseph J Grzymski, Nicole L Washington, Stephan Ossowski, Kerstin U Ludwig, Eva C Schulte, Olaf Riess, Marcin Moniuszko, Miroslaw Kwasniewski, Hamdi Mbarek, Said I Ismail, Anurag Verma, David B Goldstein, Krzysztof Kiryluk, Alessandra Renieri, Manuel A R Ferreira, J Brent Richards

Publikováno v: PLoS Genetics, Vol 18, Iss 11, p e1010367 (2022)

Host genetics is a key determinant of COVID-19 outcomes. Previously, the COVID-19 Host Genetics Initiative genome-wide association study used common variants to identify multiple loci associated with COVID-19 outcomes. However, variants with the larg

Externí odkaz: https://doaj.org/article/5f79e367675d482a9faf89902afbc030

IGFBP-3 Blocks Hyaluronan-CD44 Signaling, Leading to Increased Acetylcholinesterase Levels in A549 Cell Media and Apoptosis in a p53-Dependent Manner

Autor: Alexis Stephens, Deborah L. Heyl, Hedeel Guy Evans, Bradley Clegg, Deanna Price, Asana Williams, Robert Muterspaugh, Jeffrey Guthrie

Publikováno v: Scientific Reports, Vol 10, Iss 1, Pp 1-17 (2020)
Scientific Reports

Insulin-like growth factor binding protein-3 (IGFBP-3) belongs to a family of six IGF binding proteins. We previously found that IGFBP-3 exerts its cytotoxic effects on A549 (p53 wild-type) cell survival through a mechanism that depends on hyaluronan

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80f8b2710af5ae1f11e71843aeffa000
https://doi.org/10.1038/s41598-020-61743-3

IGFBP‐3 Blocks Hyaluronan‐CD44 Signaling, Affecting Acetylcholinesterase Levels in A549 Cell Media and Cell Viability

Autor: Hedeel Guy-Evans, Deborah L. Heyl, Jeffrey Guthrie, Robert Muterspaugh, Deanna Price, Alexis Stephens, Bradley Clegg, Asana Williams

Publikováno v: The FASEB Journal. 34:1-1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::37522341d1d6509e390658243a1c127c
https://doi.org/10.1096/fasebj.2020.34.s1.02801

Accuracy of in vivo confocal microscopy for diagnosis of basal cell carcinoma: a comparative study between handheld and wide-probe confocal imaging

Autor: Naiara Fraga-Braghiroli, M. Oliviero, Alon Scope, Raquel de Paula Ramos Castro, H. Rabinovitz, Gisele Gargantini Rezze, Alexis Stephens

Publikováno v: Journal of the European Academy of Dermatology and Venereology : JEADV. 29(6)

Background Reflectance confocal microscopy (RCM) increases specificity of identification of basal cell carcinoma (BCC). A smaller-diameter handheld RCM (HH-RCM) allows better access to limited anatomic locations. Objective To compare accuracy of HH-R

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca810139abd8655921ba41ba76179b11
https://pubmed.ncbi.nlm.nih.gov/25338750

Small brown circles: an important diagnostic clue for pigmented squamous cell carcinoma

Autor: Margaret Oliviero, Naiara Fraga-Braghiroli, Harold S. Rabinovitz, Alexis Stephens, Alon Scope

Publikováno v: Journal of the American Academy of Dermatology. 69(4)

Skin and Cancer Associates, Plantation; Department of ermatology, Sheba Medical Center and Sackler Faculty of edicine, Tel Aviv University, Tel Aviv; and the Dermatology rvice, Memorial Sloan-Kettering Cancer Center, New York. ing sources: None. abin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8630f99a5e09808afa431f13068efb61
https://pubmed.ncbi.nlm.nih.gov/24034384