Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Alexis N Peña"'
Autor:
Alexis N. Peña, Sven D. Sommerfeld, Amy E. Anderson, Jin Han, David R. Maestas, Joscelyn C. Mejias, Jennifer Woodell-May, William King, Sudipto Ganguly, Jennifer H. Elisseeff
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-20 (2022)
Abstract Osteoarthritis (OA) is a degenerative disease associated with cartilage degradation, osteophyte formation, and fibrillation. Autologous Protein Solution (APS), a type of autologous anti-inflammatory orthobiologic, is used for pain management
Externí odkaz:
https://doaj.org/article/384872bef74f48a9b2ee3d293d62666e
Autor:
Christopher Cherry, James I. Andorko, Kavita Krishnan, Joscelyn C. Mejías, Helen Hieu Nguyen, Katlin B. Stivers, Elise F. Gray-Gaillard, Anna Ruta, Jin Han, Naomi Hamada, Masakazu Hamada, Ines Sturmlechner, Shawn Trewartha, John H. Michel, Locke Davenport Huyer, Matthew T. Wolf, Ada J. Tam, Alexis N. Peña, Shilpa Keerthivasan, Claude Jordan Le Saux, Elana J. Fertig, Darren J. Baker, Franck Housseau, Jan M. van Deursen, Drew M. Pardoll, Jennifer H. Elisseeff
Publikováno v:
GeroScience.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4b0b9ded3a8a376df529d1655eb331a
https://doi.org/10.1007/s11357-023-00785-7
https://doi.org/10.1007/s11357-023-00785-7
Autor:
David R. Maestas, Liam Chung, Jin Han, Xiaokun Wang, Sven D. Sommerfeld, Erika Moore, Helen Hieu Nguyen, Joscelyn C. Mejías, Alexis N. Peña, Hong Zhang, Joshua S. T. Hooks, Alexander F. Chin, James I. Andorko, Cindy Berlicke, Kavita Krishnan, Younghwan Choi, Amy E. Anderson, Ronak Mahatme, Christopher Mejia, Marie Eric, JiWon Woo, Sudipto Ganguly, Donald J. Zack, Franck Housseau, Drew M. Pardoll, Jennifer H. Elisseeff
The immune system is increasingly recognized as an important regulator of tissue repair. We developed a regenerative immunotherapy from the helminth Schistosoma mansoni soluble egg antigen (SEA) to stimulate production of interleukin (IL)-4 and other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df3de45c6ec3c83782ab6310cc261b93
https://doi.org/10.1101/2022.05.02.490277
https://doi.org/10.1101/2022.05.02.490277
Autor:
Christopher Cherry, James I Andorko, Kavita Krishnan, Joscelyn C Mejias, Helen Hieu Nguyen, Katlin B Stivers, Elise F Gray-Gaillard, Anna Ruta, Naomi Hamada, Masakazu Hamada, Ines Sturmlechner, Shawn Trewartha, John H Michel, Locke Davenport Huyer, Matthew T Wolf, Ada Tam, Alexis N Peña, Claude Jordan Le Saux, Elana J Fertig, Darren J Baker, Franck Housseau, Jan M van Deursen, Drew M Pardoll, Jennifer H Elisseeff
Senescent cells (SnCs) contribute to normal tissue development and repair but accumulate with aging where they are implicated in a number of pathologies and diseases. Despite their pathological role and therapeutic interest, SnC phenotype and functio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fa6012a5a0758b8eed826e6293a169b
https://doi.org/10.1101/2022.03.22.485297
https://doi.org/10.1101/2022.03.22.485297
Autor:
David R. Maestas, Gedge D. Rosson, Richard L. Blosser, Locke Davenport Huyer, Hannah Y. Comeau, Erika M. Moore, Christopher Cherry, Jordan A. Garcia, Jennifer H. Elisseeff, Alexis N. Peña, Sean H. Kelly
Publikováno v:
Science Advances
Description
Biomaterial composition contributes to local, regional, and systemic alterations in B cells.
B cells are an adaptive immune target of biomaterials development in vaccine research but, despite their role in wound healing, have no
Biomaterial composition contributes to local, regional, and systemic alterations in B cells.
B cells are an adaptive immune target of biomaterials development in vaccine research but, despite their role in wound healing, have no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea7f015886980ce6ce504c1e168a91d2
https://pubmed.ncbi.nlm.nih.gov/34851674
https://pubmed.ncbi.nlm.nih.gov/34851674
Autor:
Jin Han, Christopher Cherry, Joscelyn C. Mejias, Anna Ruta, David R. Maestas, Alexis N. Peña, Helen Hieu Nguyen, Brenda Yang, Elise Gray-Gaillard, Natalie Rutkowski, Kavita Krishnan, Ada J. Tam, Elana J. Fertig, Franck Housseau, Sudipto Ganguly, Erika M. Moore, Drew M. Pardoll, Jennifer H. Elisseeff
Aging is associated with immunological changes that compromise response to infections and vaccines, exacerbate inflammatory diseases and could potentially mitigate tissue repair. Indeed, regenerative medicine strategies designed to promote tissue rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::684445d0d021b6473e6d309224142113
https://doi.org/10.1101/2021.08.17.456641
https://doi.org/10.1101/2021.08.17.456641
Publikováno v:
Medicalbiological engineeringcomputing. 59(9)
In vitro cell culture model systems often employ monocultures, despite the fact that cells generally exist in a diverse, heterogeneous microenvironment in vivo. In response, heterogeneous cultures are increasingly being used to study how cell phenoty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4917d4d9590582ae2deeeb52e035c519
https://pubmed.ncbi.nlm.nih.gov/34331635
https://pubmed.ncbi.nlm.nih.gov/34331635
Publikováno v:
Current Opinion in Biomedical Engineering. 20:100321
Restoration of soft tissue defects relies on proper structural support and bioactive components to instruct remodeling processes that have tightly controlled spatial and temporal activity not yet fully understood. One clinical mainstay for soft tissu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8542f74d3c8a48ee60486ac968e6eace
https://doi.org/10.1016/j.cobme.2021.100321
https://doi.org/10.1016/j.cobme.2021.100321
Autor:
Scott J. Bultman, Scott T. Magness, Matthew R. Redinbo, Bentley R. Midkiff, Nancy L. Allbritton, Alexis N. Peña, Dulan B. Gunasekara, Mark I. Reed, Aadra P. Bhatt, Jennifer Speer
Publikováno v:
ACS Infectious Diseases. 4:46-52
The intestinal epithelium provides a critical barrier that separates the gut microbiota from host tissues. Nonsteroidal anti-inflammatory drugs (NSAIDs) are efficacious analgesics and antipyretics and are among the most frequently used drugs worldwid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fee3b42442892dd107c72ead81881e
https://doi.org/10.1021/acsinfecdis.7b00139
https://doi.org/10.1021/acsinfecdis.7b00139
Autor:
Heather J. Faust, Matthew T. Wolf, Hong Zhang, Judith Campisi, Drew M. Pardoll, Kaitlyn Sadtler, Clifton O. Bingham, Liam Chung, David R. Maestas, Franck Housseau, Daohong Zhou, Ada J. Tam, Jennifer H. Elisseeff, Jin Han, Ok-Hee Jeon, Alexis N. Peña
Publikováno v:
J Clin Invest
Senescent cells (SnCs) are implicated in the pathogenesis of age-related diseases including osteoarthritis (OA), in part via expression of a senescence-associated secretory phenotype (SASP) that includes immunologically relevant factors and cytokines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4d79f85aaad5d70ceeb9ab4ec3609cb
https://pubmed.ncbi.nlm.nih.gov/32955487
https://pubmed.ncbi.nlm.nih.gov/32955487