Výsledky vyhledávání - "Alexis Lueras"

Stability of the trastuzumab biosimilar ABP 980 compared to reference product after intravenous bag preparation, transport and storage at various temperatures, concentrations and stress conditions

Autor: Paul Breslin, Alla Polozova, Monica Goss, Jennifer Litowski, Jane Hippenmeyer, Alexis Lueras, Shon Crampton, Darin Asbury

Publikováno v: Generics and Biosimilars Initiative Journal. 9:5-13

Study objectives: To investigate the quality and in-use stability of diluted ABP 980 (a trastuzumab biosimilar) versus reference trastuzumab to mimic dosing in intravenous (IV) bags, transportation and extended storage prior to infusion. Methods: Low

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a6566bf63d1bdaa80d2b7101a38a7ae
https://doi.org/10.5639/gabij.2020.0901.002

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Formation of Pyroglutamic Acid from N-Terminal Glutamic Acid in Immunoglobulin Gamma Antibodies

Autor: Alona Vizel, Rahul S. Rajan, Thomas M. Dillon, Tiansheng Li, Pavel V. Bondarenko, Alexis Lueras, Michael J. Treuheit, Kay Jing, Douglas Rehder, Dirk Chelius

Publikováno v: Analytical Chemistry. 78:2370-2376

The status of the N-terminus of proteins is important for amino acid sequencing by Edman degradation, protein identification by shotgun and top-down techniques, and to uncover biological functions, which may be associated with modifications. In this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e171c9c5787d4133301b113b79ed9ca7
https://doi.org/10.1021/ac051827k

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Modulation of protein aggregation by polyethylene glycol conjugation: GCSF as a case study

Autor: Tiansheng Li, Robert A. Briddell, Olaf B Kinstler, Michael J. Treuheit, Rahul S. Rajan, David N. Brems, Heather Yeghnazar, Alexis Lueras, Yu Zhang, Hiromi Arai, Christopher James Sloey, Mohini Aras, Weston Sutherland

Publikováno v: Protein science : a publication of the Protein Society. 15(5)

Polyethylene glycol (PEG) conjugation to proteins has emerged as an important technology to produce drug molecules with sustained duration in the body. However, the implications of PEG conjugation to protein aggregation have not been well understood.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::855b4ad22b0eefcb75f6637ceebd6059
https://pubmed.ncbi.nlm.nih.gov/16597829

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DNA-protein cross-linking via guanine oxidation: dependence upon protein and photosensitizer

Autor: Kristina Kurbanyan, Eric D. A. Stemp, Phuong To, Eunice V. Rivas, Arcelia González, Mary Steryo, and Daisy Ann Mah, Alexis Lueras, Cynthia Kosinski, Kim L. Nguyen

Publikováno v: Biochemistry. 42(34)

DNA-protein cross-links form when guanine undergoes a 1-electron oxidation in a flash-quench experiment, and the importance of reactive oxygen species, protein, and photosensitizer is examined here. In these experiments, a strong oxidant produced by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::82a0a8b21e4038bd551af8c7ee83a571
https://pubmed.ncbi.nlm.nih.gov/12939156

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DNA cross-linking with metallointercalator-peptide conjugates

Autor: Eric D. A. Stemp, Jacqueline K. Barton, Kimberly D. Copeland, Alexis Lueras

Publikováno v: Biochemistry. 41(42)

Short peptides have been tethered to a DNA-intercalating ruthenium complex to create a photoactivated cross-linking reagent. The ruthenium complex, [Ru(phen)(bpy')(dppz)]2+ (phen = 1,10-phenanthroline, bpy' = 4-(butyric acid)-4'-methyl-2,2'-bipyridin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d267af805ccb2912a7cf5db4ddab2c6
https://pubmed.ncbi.nlm.nih.gov/12379121

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