Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alexis Lossouarn"'
Autor:
Alexis Lossouarn, Chloé Puteaux, Laetitia Bailly, Vincent Tognetti, Laurent Joubert, Pierre‐Yves Renard, Cyrille Sabot
Publikováno v:
Chemistry – A European Journal. 28
Proteins are able to irreversibly assemble biologically active ligands from building blocks bearing complementary reactive functions due their spatial proximity, through a kinetic target-guided synthetic process (also named in situ click chemistry).
Publikováno v:
Bioconjugate Chemistry
Bioconjugate Chemistry, American Chemical Society, 2021, 32 (1), pp.63-72. ⟨10.1021/acs.bioconjchem.0c00568⟩
Bioconjugate Chemistry, American Chemical Society, 2021, 32 (1), pp.63-72. ⟨10.1021/acs.bioconjchem.0c00568⟩
Kinetic target-guided synthesis (KTGS) is a promising tool for the discovery of biologically active compounds. It relies on the identification of potent ligands that are covalently assembled by the biological targets themselves from a pool of reagent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8574843e2d3ef2d69919d13cc269abb
https://hal-normandie-univ.archives-ouvertes.fr/hal-03419994
https://hal-normandie-univ.archives-ouvertes.fr/hal-03419994
Autor:
Laetitia Bailly, Axel Frisby, Cyrille Sabot, Kévin Renault, Alexis Lossouarn, Pierre-Yves Renard, Patricia Le Nahenec-Martel
Publikováno v:
Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (20), pp.3874-3887. ⟨10.1039/D0OB00403K⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18, pp.3874-3887. ⟨10.1039/D0OB00403K⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18 (20), pp.3874-3887. ⟨10.1039/D0OB00403K⟩
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2020, 18, pp.3874-3887. ⟨10.1039/D0OB00403K⟩
International audience; A brief literature survey reveals that metal-free ligation such as the maleimide-based cycloaddition with electron-rich (hetero)dienes is a widespread tool for the assembly of (bio)molecular systems with applications in biotec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b27814bd6c85ec76483b870b52ccdc
https://hal-normandie-univ.archives-ouvertes.fr/hal-03010566
https://hal-normandie-univ.archives-ouvertes.fr/hal-03010566
Publikováno v:
Organic Letters. 18:6324-6327
A palladium-catalyzed spirocyclization forming spirooxindoles and spirodihydrobenzofurans has been achieved. Mechanistic studies suggest that the transformation proceeds through sequential carbopalladation, C-H activation, and benzyne insertion. Both
Autor:
Alexis, Lossouarn
Publikováno v:
Semaine d'études en chimie organique (SECO, 56, 2019)
Semaine d'études en chimie organique (SECO, 56, 2019), May 2019, La Clusaz, France
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2019)
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2019), Jul 2019, Caen, France
Semaine d'études en chimie organique (SECO, 56, 2019), May 2019, La Clusaz, France
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2019)
Journée de l'Ecole doctorale normande de chimie (JEDNC, 2019), Jul 2019, Caen, France
National audience
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::f62971da258c83520fd681379c88083a
https://hal-normandie-univ.archives-ouvertes.fr/hal-02404330
https://hal-normandie-univ.archives-ouvertes.fr/hal-02404330