Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Alexis Kays Leonard"'
Autor:
Anthony P. Sileno, Charles Arthur Foerder, Conor J. Macevilly, Henry R. Costantino, Alexis Kays Leonard, Steven C. Quay
Publikováno v:
Journal of Pharmaceutical Sciences. 94:1736-1746
The goal of the current study was to develop an intranasal (IN) formulation of the acetylcholinesterase inhibitor galantamine, an important therapeutic for treating Alzheimer's disease. To allow for delivering a therapeutically relevant dose, it was
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27419a56fce65d2a2f2f1ea4714ae678
https://doi.org/10.1002/jps.20389
https://doi.org/10.1002/jps.20389
Publikováno v:
BMC Neuroscience
This short review outlines the rationale, challenges, and opportunities for intranasal acetylcholinesterases, in particular galantamine. An in vitro screening model facilitated the development of a therapeutically viable formulation. In vivo testing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a551e11169020b30c744e77f7f5bc544
https://doi.org/10.1186/1471-2202-9-s3-s6
https://doi.org/10.1186/1471-2202-9-s3-s6
Autor:
Charles Arthur Foerder, Henry R. Costantino, Alexis Kays Leonard, Anthony P. Sileno, Steven C. Quay, Gordon Brandt
Publikováno v:
International journal of pharmaceutics. 335(1-2)
The purpose of the current investigation was to optimize an intranasal (IN) galantamine (an acetylcholinesterase inhibitor used for treatment of Alzheimer's disease) formulation using an in vitro tissue model, to correlate those results to in vivo bi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e926c028d7e9ceb122cc9bfbcae7153
https://pubmed.ncbi.nlm.nih.gov/17174048
https://pubmed.ncbi.nlm.nih.gov/17174048
Autor:
Daniel L. Levey, Sofija Andjelic, Jessica Flechtner, Sunil Mehta, Kenya Prince Cohane, Brian H. Barber, Paul Slusarewicz, Alexis Kays Leonard
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 177(2)
Exogenously delivered antigenic peptides complexed to heat shock proteins (HSPs) are able to enter the endogenous Ag-processing pathway and prime CD8+ CTL. It was determined previously that a hybrid peptide containing a MHC class I-binding epitope an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1242b87696d848f2aff964793f53a8bf
https://pubmed.ncbi.nlm.nih.gov/16818758
https://pubmed.ncbi.nlm.nih.gov/16818758
Autor:
Michael E. Houston, Ching-Yuan Li, Kristine T. Eiting, Ken Farber, Daniel Morris, Henry R. Costantino, Anthony P. Sileno, Kunyuan Cui, Shu-Chih Chen, Alexis Kays Leonard, Paul H. Johnson, Steven C. Quay
Publikováno v:
Journal of pharmaceutical sciences. 95(6)
Previously, a novel tight junction modulating (TJM) peptide was described affording a transient, reversible lowering of transepithelial electrical resistance (TER) in an in vitro model of nasal epithelial tissue. In the current report, this peptide h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa965e73a2228a99120d5c0fe58dc221
https://pubmed.ncbi.nlm.nih.gov/16625659
https://pubmed.ncbi.nlm.nih.gov/16625659