Výsledky vyhledávání

Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB1R) Receptor with Reduced Lipophilicity

Autor: Malliga R. Iyer, Resat Cinar, Casey M. Wood, Charles N. Zawatsky, Nathan J. Coffey, Kyu Ah Kim, Ziyi Liu, Alexis Katz, Jasmina Abdalla, Sergio A. Hassan, Yong-Sok Lee

Publikováno v: Journal of Medicinal Chemistry. 65:2374-2387

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e277b7374da3ebb78055471c174d40d
https://doi.org/10.1021/acs.jmedchem.1c01836

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Recurrent Nephritis and/or Pulmonary Hemorrhage in Patients with Anti-Glomerular Basement Membrane Disease with and without ANCA Positivity

Autor: Nicole Droz, Alexis Katz, John R. Sedor, Isaac Briskin, Rula A. Hajj Ali, Aditi Patel

Publikováno v: Glomerular Diseases. 1:60-67

Introduction: Anti-glomerular basement membrane (anti-GBM) disease is characterized by rapidly progressive glomerular nephritis with or without pulmonary hemorrhage with disease severity correlating with antibody titer. Following treatment, relapse i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7dc9dc5ffc2291a2ce142a310bc9a7a1
https://doi.org/10.1159/000515388

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Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB1R Inverse Agonist/Inducible Nitric Oxide Synthase (iNOS) Inhibitors for the Treatment of Liver Fibrosis

Autor: Nathan J. Coffey, George Kunos, Tony Jourdan, Katalin Erdelyi, Pal Pacher, Resat Cinar, Malliga R. Iyer, Alexis Katz, Michael Gao

Publikováno v: Journal of Medicinal Chemistry. 60:1126-1141

We report the design, synthesis, and structure–activity relationships of novel dual-target compounds with antagonist/inverse agonist activity at cannabinoid receptor type 1 (CB1R) and inhibitory effect on inducible nitric oxide synthase (iNOS). A s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9f50ca25c4164233df22f105c54dacaa
https://doi.org/10.1021/acs.jmedchem.6b01504

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069. DOES ANTI-GLOMERULAR BASEMENT (ANTI-GBM) ANTIBODY POSITIVITY CORRELATE WITH RELAPSE IN PATIENTS WITH ANTI-GBM DISEASE?

Autor: Alexis Katz, Rula A. Hajj-Ali, Nicole Droz, John R. Sedor

Publikováno v: Rheumatology. 58

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fc99c4a77836002499f9bcd1a194c0db
https://doi.org/10.1093/rheumatology/kez058.009

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Design, Synthesis, and Biological Evaluation of Novel, Non-Brain-Penetrant, Hybrid Cannabinoid CB

Autor: Malliga R, Iyer, Resat, Cinar, Alexis, Katz, Michael, Gao, Katalin, Erdelyi, Tony, Jourdan, Nathan J, Coffey, Pal, Pacher, George, Kunos

Publikováno v: Journal of medicinal chemistry. 60(3)

We report the design, synthesis, and structure-activity relationships of novel dual-target compounds with antagonist/inverse agonist activity at cannabinoid receptor type 1 (CB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bd52aeb618efdae8b633a2748eef0616
https://pubmed.ncbi.nlm.nih.gov/28085283

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Akademický článek

KCNQ Current Contributes to Inspiratory Burst Termination in the Pre-Bötzinger Complex of Neonatal Rats in vitro

Autor: Ann L. Revill, Alexis Katzell, Christopher A. Del Negro, William K. Milsom, Gregory D. Funk

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

The pre-Bötzinger complex (preBötC) of the ventral medulla generates the mammalian inspiratory breathing rhythm. When isolated in explants and deprived of synaptic inhibition, the preBötC continues to generate inspiratory-related rhythm. Mechanism

Externí odkaz: https://doaj.org/article/c73d03ece89c41cd9911432514397d9f

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