Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexis I. Cocozaki"'
Autor:
Caryn Hale, Nancy F. Ramia, Yaming Shao, Michael P. Terns, Rebeca Terns, Hong Li, Michael S. Spilman, Alexis I. Cocozaki, Scott M. Stagg
Publikováno v:
Molecular Cell. 52:146-152
Summary Bacterial and archaeal clustered regularly interspaced short palindromic repeat (CRISPR) loci capture virus and plasmid sequences and use them to recognize and eliminate these invaders. CRISPR RNAs (crRNAs) containing the acquired sequences a
Autor:
Jamie H. D. Cate, Roger B. Altman, Peter Doig, Ed T. Buurman, D. Bryan Prince, Steven L. Kazmirski, Alexis I. Cocozaki, Scott C. Blanchard, Jian Huang, Andrew D. Ferguson
Mutations conferring resistance to translation inhibitors often alter the structure of rRNA. Reduced susceptibility to distinct structural antibiotic classes may, therefore, emerge when a common ribosomal binding site is perturbed, which significantl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e1b2f5cc115d240e70bdfd025dc1568
https://europepmc.org/articles/PMC4961145/
https://europepmc.org/articles/PMC4961145/
Autor:
Caryn Hale, Michael P. Terns, Nancy F. Ramia, Hong Li, Yaming Shao, Alexis I. Cocozaki, Rebecca M. Terns
Publikováno v:
Structure. 20(3):545-553
SummaryCmr2 is the largest and an essential subunit of a CRISPR RNA-Cas protein complex (the Cmr complex) that cleaves foreign RNA to protect prokaryotes from invading genetic elements. Cmr2 is thought to be the catalytic subunit of the effector comp
Bacteriophage P22 Antitermination boxB Sequence Requirements Are Complex and Overlap with Those of λ
Publikováno v:
Journal of Bacteriology. 190:4263-4271
Transcription antitermination in phages λ and P22 uses N proteins that bind to similar boxB RNA hairpins in regulated transcripts. In contrast to the λ N-boxB interaction, the P22 N-boxB interaction has not been extensively studied. A nuclear magne
Autor:
Anatoly M. Ruvinsky, Kumar Thakur, Liang Zhao, Alexis I. Cocozaki, David C. McKinney, Gregory S. Basarab, Clay W Scott, Ed T. Buurman, Matthew D. Miller, Sridhar Narayan, Melinda A. Foulk
Negamycin is a natural product with antibacterial activity against a broad range of Gram-negative pathogens. Recent revelation of its ribosomal binding site and mode of inhibition has reinvigorated efforts to identify improved analogues with clinical
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a7f03935e32afd7ddc265249a7ba3b
https://europepmc.org/articles/PMC4538447/
https://europepmc.org/articles/PMC4538447/
Publikováno v:
Clinical Microbiology and Infection. 12(1):86-90
Susceptibility patterns of Streptococcus pneumoniae and Haemophilus influenzae collected over a 5-year period in a Beirut general university hospital were studied. Only 40.6–50% of S. pneumoniae isolates were susceptible to penicillin G. Susceptibi
Publikováno v:
Genesdevelopment. 28(21)
The effector complex of the Cmr/type III-B CRISPR (clustered regularly interspaced short palindromic repeat)–Cas (CRISPR-associated) system cleaves RNAs recognized by the CRISPR RNA (crRNA) of the complex and includes six protein subunits of unknow
Autor:
Farzin Gharadaghi, Alexis I. Cocozaki, Kelly Jacques, Sylvie Guichard, Caroline Vallaster, Brendan D. Price
Publikováno v:
Molecular Cancer Research. 15:B14-B14
Bromodomain containing protein BRD9 has been identified as a component of the SWI/SNF chromatin remodeling complex. Next generation sequencing studies have revealed that SWI/SNF is the most highly perturbed chromatin remodeling complex in cancer with
Publikováno v:
Structure (London, England : 1993). 21(3)
SummaryThe Cmr complex is an RNA-guided effector complex that cleaves invader RNA in the prokaryotic immune response mediated by the CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat)-Cas system. Here, we report the crystal structure o
Antitermination in bacteriophage P22, a lambdoid phage, uses the arginine-rich domain of the N protein to recognize boxB RNAs in the nut site of two regulated transcripts. Using an antitermination reporter system, we screened libraries in which each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bea32bb18aa1e554a25b991d712401f6
https://europepmc.org/articles/PMC2583623/
https://europepmc.org/articles/PMC2583623/