Zobrazeno 1 - 6 of 6 pro vyhledávání: '"Alexis Diane Leal"'
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Impact of early-onset colorectal cancer on utilization of chemotherapy and outcomes in patients with stage II disease
Autor: Jacob Beck Leary, Junxiao Hu, Sean Davis, Alexis Diane Leal, S. Lindsey Davis, Sunnie S. Kim, Robert William Lentz, Tyler Friedrich, Jon Vogel, Whitney Herter, Brandon C. Chapman, Wells A. Messersmith, Christopher Hanyoung Lieu
Publikováno v: Journal of Clinical Oncology. 41:85-85
85 Background: Rising rates of early-onset colorectal cancer (EOCRC) pose a dilemma for clinicians when deciding how to treat early-stage patients to maximize outcomes. While standard-of-care for Stage II colon cancer is largely surgical resection, e
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb9e6b9c389113eecb69cf87526bbb2d
https://doi.org/10.1200/jco.2023.41.4_suppl.85
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3
First-in-human phase 1 trial of ELI-002 immunotherapy as treatment for subjects with Kirsten rat sarcoma (KRAS)-mutated pancreatic ductal adenocarcinoma and other solid tumors
Autor: Shubham Pant, Muhammad Furqan, Raghad Muhsin Abdul-Karim, Vincent Chung, Craig E. Devoe, Melissa Lynne Johnson, Alexis Diane Leal, Haeseong Park, Zev A. Wainberg, Esther Welkowsky, Christopher M. Haqq, Eileen Mary O'Reilly, Colin D. Weekes
Publikováno v: Journal of Clinical Oncology. 40:TPS2701-TPS2701
TPS2701 Background: Mutations in KRAS and NRAS occur in one quarter of human solid tumors. The G12D allele is the most commonly occurring variant in pancreatic, colorectal, non-small cell lung, ovarian, biliary and gallbladder cancers. ELI-002 2P is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e768fbc433d475a92db0dac65f03f3ad
https://doi.org/10.1200/jco.2022.40.16_suppl.tps2701
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4
A phase Ib study of the combination of alisertib (Aurora A kinase inhibitor) and MLN0128 (dual TORC1/2 Inhibitor) in patients with advanced solid tumors, final expansion cohort data
Autor: S. Lindsey Davis, Alexis Diane Leal, Wells A. Messersmith, Christopher Hanyoung Lieu, Elaine T. Lam, Bradley Corr, Cindy L. O'Bryant, Natalie Julie Serkova, Todd Pitts, Jennifer Robinson Diamond
Publikováno v: Journal of Clinical Oncology. 40:3112-3112
3112 Background: In prior work, senescence and up-regulation of genes in the PI3K/AKT/mTor pathway were observed in patient-derived xenograft models treated with alisertib to resistance, and tumor growth inhibition was observed when MLN0128 (sapanise
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8488a139a7e9cbc6d318390cc5b1c1c8
https://doi.org/10.1200/jco.2022.40.16_suppl.3112
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5
A phase II study of pembrolizumab, binimetinib, and bevacizumab in patients with microsatellite-stable, refractory, metastatic colorectal cancer (mCRC)
Autor: Tyler Friedrich, Patrick Jud Blatchford, Robert William Lentz, S. Lindsey Davis, Sunnie S. Kim, Alexis Diane Leal, Zoe Van De Voorde, Matthew R Lee, Meredith Waring, Tiffany Cull, Anne Martin, S. Gail Eckhardt, Wells A. Messersmith, Christopher Hanyoung Lieu
Publikováno v: Journal of Clinical Oncology. 40:118-118
118 Background: To date, immune-checkpoint inhibition for microsatellite stable (MSS) mCRC has been ineffective, though targeted therapy combination strategies may be promising. This phase II, investigator-initiated trial (NCT03475004) was designed t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a8aa0959e24eee25c4b1b5ce51d19054
https://doi.org/10.1200/jco.2022.40.4_suppl.118
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