Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Alexio Capovilla"'
Autor:
Sheena Saayman, Samantha Barichievy, Alexio Capovilla, Kevin V Morris, Patrick Arbuthnot, Marc S Weinberg
Publikováno v:
PLoS ONE, Vol 3, Iss 7, p e2602 (2008)
RNA Interference (RNAi) effectors have been used to inhibit rogue RNAs in mammalian cells. However, rapidly evolving sequences such as the human immunodeficiency virus type 1 (HIV-1) require multiple targeting approaches to prevent the emergence of e
Externí odkaz:
https://doaj.org/article/7d8f9535fc8349d4998b63798f48546d
Publikováno v:
AIDS Research and Human Retroviruses. 30:1001-1005
The tight bottleneck during HIV-1 transmission generally results in only a single virus variant being transmitted. Investigation of the HIV-1 envelope glycoprotein (Env) can identify vulnerabilities of transmitting viruses that can be targeted by vac
Autor:
Nichole Cerutti, Maria A. Papathanasopoulos, Alexio Capovilla, Vinesh Jugnarain, Mark Killick
Publikováno v:
Journal of Biological Chemistry. 289:10455-10465
Human CD4 is a membrane-bound glycoprotein expressed on the surface of certain leukocytes, where it plays a key role in the activation of immunostimulatory T cells and acts as the primary receptor for human immunodeficiency virus (HIV) glycoprotein (
Publikováno v:
Biochimica et biophysica acta. 1860(9)
Background CD4 is a glycoprotein expressed on the surfaces of certain immune cells. On lymphocytes, an important function of CD4 is to co-engage Major Histocompatibility Complex (MHC) molecules with the T Cell Receptor (TCR), a process that is essent
Autor:
Michael Haertlein, V. Trevor Forsyth, Maria A. Papathanasopoulos, Nichole Cerutti, Jennifer Channell, Gavin R. Owen, Alexio Capovilla, Edward P. Mitchell
Publikováno v:
Biochemistry. 55(15)
CD4 is expressed on the surface of specific leukocytes where it plays a key role in the activation of immunostimulatory T-cells and acts as a primary receptor for HIV-1 entry. CD4 has four ecto-domains (D1-D4) of which D1, D2, and D4 contain disulfid
Autor:
Mark Killick, Barry V. Mendelow, Wendy Stevens, Maria A. Papathanasopoulos, Alexio Capovilla, Nichole Cerutti, Makobetsa Khati, Grant Bredell Napier
Publikováno v:
Journal of Biological Chemistry. 285:25743-25752
HIV-1 enters cells via interaction between the trimeric envelope (Env) glycoprotein gp120/gp41 and the host cell surface receptor molecule CD4. The requirement of CD4 for viral entry has rationalized the development of recombinant CD4-based proteins
Autor:
Nonkululeko Mlaba, Laurent Bélec, Philippe Mayaud, Raul Rosas, Alexio Capovilla, Godspower Akpomiemie, Wendy Stevens, Tim Clayton, Sinead Delany, Jérôme LeGoff
Publikováno v:
JAIDS Journal of Acquired Immune Deficiency Syndromes. 49:406-409
Methods: We compared the performance of 3 collection methods for cervicovaginal secretions [cervicovaginal lavage (CVL), CVL enriched with a cervical swab (eCVL), and vaginal tampon (VT)] to identify the most reliable method for detection of cervicov
Autor:
Mark Killick, Michelle L. Grant, Alexio Capovilla, Nichole Cerutti, Maria A. Papathanasopoulos
Publikováno v:
Vaccine. 33(46)
The ability to induce a broadly neutralizing antibody (bNAb) response following vaccination is regarded as a crucial aspect in developing an effective vaccine against human immunodeficiency virus type 1 (HIV-1). The bNAbs target the HIV-1 envelope gl