Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Alexie A. Larson"'
Autor:
Robert W. Arpke, Ahmed S. Shams, Brittany C. Collins, Alexie A. Larson, Nguyen Lu, Dawn A. Lowe, Michael Kyba
Publikováno v:
Skeletal Muscle, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Background Although muscle regenerative capacity declines with age, the extent to which this is due to satellite cell-intrinsic changes vs. environmental changes has been controversial. The majority of aging studies have investigated hindlim
Externí odkaz:
https://doaj.org/article/7eb0d988b8964e34aba5ccd88b2c1fad
Autor:
Brittany C. Collins, Robert W. Arpke, Alexie A. Larson, Cory W. Baumann, Ning Xie, Christine A. Cabelka, Nardina L. Nash, Hanna-Kaarina Juppi, Eija K. Laakkonen, Sarianna Sipilä, Vuokko Kovanen, Espen E. Spangenburg, Michael Kyba, Dawn A. Lowe
Publikováno v:
Cell Reports, Vol 28, Iss 2, Pp 368-381.e6 (2019)
Summary: Skeletal muscle mass, strength, and regenerative capacity decline with age, with many measures showing a greater deterioration in females around the time estrogen levels decrease at menopause. Here, we show that estrogen deficiency severely
Externí odkaz:
https://doaj.org/article/37ec4ce13b9944809954e964e9bbeabf
Autor:
Alexie A. Larson, Ahmed S. Shams, Shawna L. McMillin, Brian P. Sullivan, Cha Vue, Zachery A. Roloff, Eric Batchelor, Michael Kyba, Dawn A. Lowe
Publikováno v:
American Journal of Physiology-Cell Physiology. 322:C1123-C1137
The size of the satellite cell pool is reduced in estradiol (E2)-deficient female mice and humans. Here, we use a combination of in vivo and in vitro approaches to identify mechanisms, whereby E2 deficiency impairs satellite cell maintenance. By meas
Publikováno v:
Exp Physiol
New findings What is the central question of this study? Oestradiol (E2 ) plays an important role in regulating skeletal muscle strength in females. To what extent does E2 deficiency affect recovery of strength and satellite cell number when muscle i
Autor:
Cory W. Baumann, Alexie A. Larson, Rebecca Barok, Brendan J. Dougherty, Dawn A. Lowe, Pangdra Vang
Publikováno v:
The FASEB Journal. 35
Autor:
Dawn A. Lowe, Angus Lindsay, James M. Ervasti, James S. Hodges, Alexie A. Larson, William M. Southern, Preston M. McCourt
Publikováno v:
FEBS J
Eccentric contractions (ECCs) induce force loss in several skeletal muscles of dystrophin-deficient mice (mdx), with the exception of the soleus (Sol). The eccentric force : isometric force (ECC : ISO), expression level of utrophin, fiber type distri
Publikováno v:
Journal of Applied Physiology. 126:363-375
Mutation to the dystrophin gene causes skeletal muscle weakness in patients with Duchenne muscular dystrophy (DMD) or Becker muscular dystrophy (BMD). Deliberation continues regarding implications of prescribing exercise for these patients. The purpo
Tetrahydrobiopterin synthesis and metabolism is impaired in dystrophin-deficient mdx mice and humans
Autor:
Alexie A. Larson, Peter I. Karachunski, Dawn A. Lowe, John Holm, James M. Ervasti, Cory W. Baumann, Preston M. McCourt, Bailey H. Kemp, Angus Lindsay
Publikováno v:
Acta physiologica (Oxford, England)REFERENCES. 231(4)
Aim Loss of dystrophin causes oxidative stress and affects nitric oxide synthase-mediated vascular function in striated muscle. Because tetrahydrobiopterin is an antioxidant and co-factor for nitric oxide synthase, we tested the hypothesis that tetra
Autor:
Rebecca Barok, Alexie A. Larson, Cory W. Baumann, Pangdra Vang, Brendan J. Dougherty, Dawn A. Lowe
Publikováno v:
PLoS ONE, Vol 16, Iss 3, p e0249472 (2021)
PLoS ONE
PLoS ONE
Female carriers of Duchenne muscular dystrophy (DMD) presenting with DMD symptomology similar to males with DMD, such as skeletal muscle weakness and cardiomyopathy, are termed manifesting carriers. There is phenotypic variability among manifesting c
Autor:
Alexie A. Larson, Molly N. Pantelic, Shelby E. Florida, Lisa M. Larkin, Brian C Syverud, Brittany L. Rodriguez
Publikováno v:
Cells Tissues Organs. 205:197-207
Our lab showed that administration of dexamethasone (DEX) stimulated myogenesis and resulted in advanced structure in our engineered skeletal muscle units (SMU). While administration of 25 nM DEX resulted in the most advanced structure, 10 nM dosing