Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexia de Matos Czeczot"'
Autor:
Alexia de Matos Czeczot, Mauro Neves Muniz, Marcia Alberton Perelló, Éverton Edésio Dinis Silva, Luís Fernando Saraiva Macedo Timmers, Andresa Berger, Laura Calle Gonzalez, Guilherme Arraché Gonçalves, Sidnei Moura, Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
The crystallographic structure of the FolB enzyme from Mycobacterium tuberculosis (MtFolB), complexed with its inhibitor 8-mercaptoguanine (8-MG), was elucidated at a resolution of 1.95 Å. A novel series of S8-functionalized 8-MG derivatives were sy
Externí odkaz:
https://doaj.org/article/c2c86a72e6544669bcd7eb8afcc9a3b3
Autor:
Virginia Carla de Almeida Falcão, Alexia de Matos Czeczot, Mohammad Maqusood Alam, Kyu-Ho Paul Park, Jinyeong Heo, Minjeong Woo, Ana Micaela Camini, Luis Fernando Saraiva Macedo Timmers, David Shum, Marcia Alberton Perelló, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro, Vincent Delorme
Publikováno v:
Frontiers in Tropical Diseases, Vol 5 (2024)
IntroductionAntifolates were among the first broad-spectrum compounds used as antimycobacterial agents and can still be of use when no other therapeutic options are available. The discovery of compounds targeting the essential folate synthesis pathwa
Externí odkaz:
https://doaj.org/article/f86800fbdee447ed8317cac3db0afcf5
Autor:
Alexia de Matos Czeczot, Candida Deves Roth, Rodrigo Gay Ducati, Kenia Pissinate, Raoní Scheibler Rambo, Luís Fernando Saraiva Macedo Timmers, Bruno Lopes Abbadi, Fernanda Souza Macchi, Víctor Zajaczkowski Pestana, Luiz Augusto Basso, Pablo Machado, Cristiano Valim Bizarro
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 847-855 (2021)
The dihydroneopterin aldolase (DHNA, EC 4.1.2.25) activity of FolB protein is required for the conversion of 7,8-dihydroneopterin (DHNP) to 6-hydroxymethyl-7,8-dihydropterin (HP) and glycolaldehyde (GA) in the folate pathway. FolB protein from Mycoba
Externí odkaz:
https://doaj.org/article/adfbb94f578e4e9eae055faaa791c0f4
Autor:
Talita Freitas de Freitas, Candida Deves Roth, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Marcia Alberton Perelló, Alexia de Matos Czeczot, Eduardo Vieira de Souza, Ana Flávia Borsoi, Pablo Machado, Cristiano Valim Bizarro, Luiz Augusto Basso, Luis Fernando Saraiva Macedo Timmers
Publikováno v:
Journal of computer-aided molecular design.
Tuberculosis (TB) is one of the main causes of death from a single pathological agent, Mycobacterium tuberculosis (Mtb). In addition, the emergence of drug-resistant TB strains has exacerbated even further the treatment outcome of TB patients. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1930acb0b3493be95dd9a1710dd85e10
https://pubmed.ncbi.nlm.nih.gov/36547753
https://pubmed.ncbi.nlm.nih.gov/36547753
Autor:
Ana Flávia Borsoi, Laura Manzoli Alice, Nathalia Sperotto, Alessandro Silva Ramos, Bruno Lopes Abbadi, Fernanda Souza Macchi Hopf, Adilio da Silva Dadda, Raoní S. Rambo, Rodrigo Braccini Madeira Silva, Josiane Delgado Paz, Kenia Pissinate, Mauro Neves Muniz, Christiano Ev Neves, Luiza Galina, Laura Calle González, Marcia Alberton Perelló, Alexia de Matos Czeczot, Mariana Leyser, Sílvia Dias de Oliveira, Graziela de Araújo Lock, Bibiana Verlindo de Araújo, Teresa Dalla Costa, Cristiano Valim Bizarro, Luiz Augusto Basso, Pablo Machado
Publikováno v:
ACS medicinal chemistry letters. 13(8)
Using cycloalkyl and electron-donating groups to decrease the carbonyl electrophilicity, a novel series of 2-(quinoline-4-yloxy)acetamides was synthesized and evaluated as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35a7a635d9e1c691e060f2965ac3dbf0
https://pubmed.ncbi.nlm.nih.gov/35978694
https://pubmed.ncbi.nlm.nih.gov/35978694
Autor:
Josiane Delgado Paz, Nathalia Denise de Moura Sperotto, Alessandro Silva Ramos, Kenia Pissinate, Valnês da Silva Rodrigues Junior, Bruno Lopes Abbadi, Ana Flávia Borsoi, Raoní Scheibler Rambo, Ana Carolina Corso Minotto, Adilio da Silva Dadda, Luiza Galina, Fernanda Souza Macchi Hopf, Mauro Neves Muniz, Leonardo Kras Borges Martinelli, Candida Deves Roth, Rodrigo Braccini Madeira Silva, Marcia Alberton Perelló, Alexia de Matos Czeczot, Christiano Ev Neves, Lovaine Silva Duarte, Mariana Leyser, Sílvia Dias de Oliveira, Cristiano Valim Bizarro, Pablo Machado, Luiz Augusto Basso
Publikováno v:
European Journal of Medicinal Chemistry. 245:114908
Herein a series of 4-aminoquinolines were synthesized in an attempt to optimize and study the structural features related to LABIO-17 biological activity, a Mycobacterium tuberculosis NADH-dependent enoyl-acyl carrier protein reductase (MtInhA) inhib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4ddf8b5254d536a5b68e70bfefd03c7
https://doi.org/10.1016/j.ejmech.2022.114908
https://doi.org/10.1016/j.ejmech.2022.114908