Cervical Lymph Nodes as a Selective Niche for Brucella during Oral Infections.

Autor: Kristine von Bargen, Aurélie Gagnaire, Vilma Arce-Gorvel, Béatrice de Bovis, Fannie Baudimont, Lionel Chasson, Mile Bosilkovski, Alexia Papadopoulos, Anna Martirosyan, Sandrine Henri, Jean-Louis Mège, Bernard Malissen, Jean-Pierre Gorvel

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121790 (2014)

Cervical lymph nodes (CLN) are the first lymph nodes encountered by material taking the oral route. To study their role in orally acquired infections, we analyzed 307 patients of up to 14 years treated in the university clinic of Skopje, Macedonia, f

Externí odkaz: https://doaj.org/article/d57f932a38f447ecad9e8a3ed6ef1496

Omp25‐dependent engagement of SLAMF1 byBrucella abortusin dendritic cells limits acute inflammation and favours bacterial persistence in vivo

Autor: Clara Degos, Lisiena Hysenaj, Jean-Pierre Gorvel, Stéphane Méresse, Sylvie Mémet, Juliana Cassataro, Vilma Arce-Gorvel, Gabriela Gonzalez-Espinoza, Alexia Papadopoulos, Aurélie Gagnaire, Karina A. Pasquevich

Publikováno v: Cellular Microbiology
Cellular Microbiology, Wiley, 2020, 22 (4), ⟨10.1111/cmi.13164⟩
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Cellular Microbiology, 2020, 22 (4), ⟨10.1111/cmi.13164⟩

The strategies by which intracellular pathogenic bacteria manipulate innate immunity to establish chronicity are poorly understood. Here, we show that Brucella abortus outer membrane protein Omp25 specifically binds the immune cell receptor SLAMF1 in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df12158942ba66e65c0b413a9063a357
https://doi.org/10.1111/cmi.13164

Subversion of mouse dendritic cell subset function by bacterial pathogens

Autor: Jean-Pierre Gorvel, Alexia Papadopoulos

Publikováno v: Microbial Pathogenesis. 89:140-149

Dendritic cells (DCs) play an important role as sentinels of the immune system in initiating and controlling the quality of adaptive immune responses. Located at entry points of the host they can sense and alert the body from dangers such as infectio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2db80ac3d5539cad6aa4debdd1f14e7
https://doi.org/10.1016/j.micpath.2015.10.004

COX-2 Inhibition Reduces Brucella Bacterial Burden in Draining Lymph Nodes

Autor: Jean-Pierre Gorvel, Aurélie Gagnaire, Jean-Louis Mege, Laurent Gorvel, Kristine von Bargen, Alexia Papadopoulos

Publikováno v: Frontiers in Microbiology
Frontiers in Microbiology, 2016, 7, ⟨10.3389/fmicb.2016.01987⟩
Frontiers in Microbiology, Vol 7 (2016)
Frontiers in Microbiology, Frontiers Media, 2016, 7, ⟨10.3389/fmicb.2016.01987⟩

International audience; Brucella is a Gram-negative facultative intracellular bacterium responsible for a chronic disease known as brucellosis, the most widespread re-emerging zoonosis worldwide. Establishment of a Th1-mediated immune response charac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::351380d52e8e2b0f28a99ac3f021a782
https://hal.science/hal-01438485/document