Výsledky vyhledávání - "Alexia M. Thomas"

Transgenic Archaerhodopsin-3 Expression in Hypocretin/Orexin Neurons Engenders Cellular Dysfunction and Features of Type 2 Narcolepsy

Autor: Thomas S. Kilduff, Tomomi Tsunematsu, Akihiro Yamanaka, Alexia M Thomas, Kelsie Bogyo, Rhîannan H. Williams

Publikováno v: J Neurosci
J. Neurosci. 39, 9435-9452 (2019)
The Journal of Neuroscience

Narcolepsy, characterized by excessive daytime sleepiness, is associated with dysfunction of the hypothalamic hypocretin/orexin (Hcrt) system, either due to extensive loss of Hcrt cells (Type 1, NT1) or hypothesized Hcrt signaling impairment (Type 2,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b41acf8a85b21b2467549af2c87648
https://europepmc.org/articles/PMC6867809/

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Excitation of Cortical nNOS/NK1R Neurons by Hypocretin 1 is Independent of Sleep Homeostasis

Autor: Sarah Black, Thomas S. Kilduff, Alexia M Thomas, Juliette Piquet, Rhîannan H. Williams, Bruno Cauli

Publikováno v: Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2019, 29 (3), pp.1090-1108. ⟨10.1093/cercor/bhy015⟩
Cereb. Cortex 29, 1090-1108 (2019)

International audience; We have proposed that cortical nNOS/NK1R interneurons have a role in sleep homeostasis. The hypocretins (orexins) are wake-promoting neuropeptides and hypocretin/orexin (Hcrt) neurons project to the cortex. Hcrt peptides affec

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d19201461be3eec6bcbc43ab600925b
https://hal.sorbonne-universite.fr/hal-02168362/file/WilliamsEtAl.(2019)CerCor-accepted.pdf

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Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease

Autor: Thomas S. Kilduff, Tsui-Ming Chen, Jeremiah B. Palmerston, Morairty, Alexia M Thomas, Simon P. Fisher, Schwartz, Miller Ma, Wurts-Black S

Publikováno v: Sleep. 39:379-391

STUDY OBJECTIVES Patients with Huntington's disease (HD) show a high prevalence of sleep disorders that typically occur prior to the onset of motoric symptoms and neurodegeneration. Our understanding of the pathophysiological alterations in premanife

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79aa90eeeec4a56c163d4bc31ec0cb4b
https://doi.org/10.5665/sleep.5448

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Cortical nNOS/NK1 Receptor Neurons are Regulated by Cholinergic Projections From the Basal Forebrain

Autor: Alexia M Thomas, Jacqueline Vazquez-DeRose, Juliette Piquet, Thomas S. Kilduff, Rhîannan H. Williams, Bruno Cauli

Publikováno v: Cerebral Cortex (New York, N.Y.: 1991)
Cerebral Cortex (New York, N.Y.: 1991), 2017, pp.1-21. ⟨10.1093/cercor/bhx102⟩
Cerebral Cortex
Cerebral Cortex, Oxford University Press (OUP), 2017, pp.1-21. ⟨10.1093/cercor/bhx102⟩
Cerebral Cortex, 2018, 28 (6), pp.1959-1979. ⟨10.1093/cercor/bhx102⟩

International audience; Cholinergic (ACh) basal forebrain (BF) neurons are active during wakefulness and rapid eye movement (REM) sleep and are involved in sleep homeostasis. We have previously shown in adult animals that cortical neurons that expres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::342f285852ea05afdc3d7febd36c00a3
https://hal.archives-ouvertes.fr/hal-01541348

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Cntnap2 Knockout Rats and Mice Exhibit Epileptiform Activity and Abnormal Sleep-Wake Physiology

Autor: Michael D. Schwartz, Thomas S. Kilduff, Alexia M Thomas, Michael Saxe

Publikováno v: Sleep. 40(1)

Study objectives Although recent innovations have enabled modification of the rat genome, it is unclear whether enhanced utility of rodents as human disease models will result. We compared electroencephalogram (EEG) and behavioral phenotypes of rats

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::294818178f9f872bd4722ad9b7f2ca19
https://pubmed.ncbi.nlm.nih.gov/28364455

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0122 HYPOCRETIN AFFECTS THE EXCITABILITY OF CORTICAL NNOS/NK1 NEURONS

Autor: Bruno Cauli, Rhîannan H. Williams, Sarah Black, Juliette Piquet, Alexia M Thomas, Thomas S. Kilduff

Publikováno v: Sleep. 40:A45-A46

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::659d6e1ad5aa943ce23434365dbba6ec
https://doi.org/10.1093/sleepj/zsx050.121

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Group I metabotropic glutamate receptor antagonists alter select behaviors in a mouse model for fragile X syndrome

Autor: Nghiem Bui, Lisa A. Yuva-Paylor, Alexia M. Thomas, Richard Paylor, Jennifer R. Perkins

Publikováno v: Psychopharmacology. 219:47-58

Studies in the Fmr1 knockout (KO) mouse, a model of fragile X syndrome (FXS), suggest that excessive signaling through group I metabotropic glutamate receptors (mGluRs), comprised of subtypes mGluR1 and mGluR5, may play a role in the pathogenesis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2b8c61059d0796501c6b88b985d4e1
https://doi.org/10.1007/s00213-011-2375-4

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Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety

Autor: Richard Paylor, April Burant, Deanna Graham, Alexia M. Thomas, Lisa A. Yuva-Paylor, Nghiem Bui

Publikováno v: Psychopharmacology. 204:361-373

An increasing number of investigators utilize the marble-burying assay despite the paucity of information available regarding what underlies the behavior.We tested the possibility that a genetic component underlies marble burying in mice and if there

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4be49be10315421d5542965df488b7fd
https://doi.org/10.1007/s00213-009-1466-y

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