Výsledky vyhledávání - "Alexia Karen Cotte"

Akademický článek

Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Autor: Alexia Karen Cotte, Virginie Aires, Maxime Fredon, Emeric Limagne, Valentin Derangère, Marion Thibaudin, Etienne Humblin, Alessandra Scagliarini, Jean-Paul Pais de Barros, Patrick Hillon, François Ghiringhelli, Dominique Delmas

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)

Lipid droplets (LD) accumulation correlates with colorectal cancer (CRC) relapse. Here the authors show that chemotherapy induces LD synthesis via acyltransferase LPCAT2 which, in turn, promotes chemoresistance via LD accumulation both in vitro and i

Externí odkaz: https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a2

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Akademický článek

LPCAT2 controls chemoresistance in colorectal cancer

Autor: Alexia Karen Cotte, Virginie Aires, François Ghiringhelli, Dominique Delmas

Publikováno v: Molecular & Cellular Oncology, Vol 5, Iss 3 (2018)

Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC c

Externí odkaz: https://doaj.org/article/9000032af48e4fccb395f82ac04468d6

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Sequential targeting of PARP with carboplatin inhibits primary tumour growth and distant metastasis in triple-negative breast cancer

Autor: Michèle Beniey, Audrey Hubert, Takrima Haque, Alexia Karen Cotte, Nelly Béchir, Xiaomeng Zhang, Danh Tran-Thanh, Saima Hassan

Publikováno v: British Journal of Cancer. 128:1964-1975

Background Patients with triple-negative breast cancer (TNBC) develop early recurrence. While PARP inhibitors (PARPi) have demonstrated potential in BRCA1/2-mutant (BRCAMUT) TNBC, durable responses will likely be achieved if PARPi are used in combina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b92245e18201b7776acbeb169312e070
https://doi.org/10.1038/s41416-023-02226-w

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Lysophosphatidylcholine acyltransferase 2-mediated lipid droplet production supports colorectal cancer chemoresistance

Autor: Etienne Humblin, Virginie Aires, Valentin Derangère, Marion Thibaudin, Patrick Hillon, Maxime Fredon, Alessandra Scagliarini, Dominique Delmas, Jean-Paul Pais de Barros, Emeric Limagne, Alexia Karen Cotte, François Ghiringhelli

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.322. ⟨10.1038/s41467-017-02732-5⟩
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.322. 〈https://www.nature.com/articles/s41467-017-02732-5〉. 〈10.1038/s41467-017-02732-5〉

Lipid droplet (LD) accumulation is a now well-recognised hallmark of cancer. However, the significance of LD accumulation in colorectal cancer (CRC) biology is incompletely understood under chemotherapeutic conditions. Since drug resistance is a majo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::043065de1485aa2c04f8e0db270ab3b5
https://doaj.org/article/ebbb44a3f0364d6cb5aecb457ae581a2

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Phospholipid profiles and hepatocellular carcinoma risk and prognosis in cirrhotic patients

Autor: Alexia Karen, Cotte, Vanessa, Cottet, Virginie, Aires, Thomas, Mouillot, Maud, Rizk, Sandrine, Vinault, Christine, Binquet, Jean-Paul Pais, de Barros, Patrick, Hillon, Dominique, Delmas

Publikováno v: Oncotarget

Background Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide. Phospholipids are now well-recognised players in tumour progression. Their metabolic tissue alterations can be associated with plasmatic modifications. The aim of th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8f6ab5e0abd58b951c81ac6f424c778f
https://pubmed.ncbi.nlm.nih.gov/31040908

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Liver X Receptor ligand cytotoxicity in colon cancer cells and not in normal colon epithelial cells depends on LXRβ subcellular localization

Autor: Angélique Chevriaux, Romain Boidot, Sylvain Ladoire, François Ghiringhelli, Flavie Courtaut, Valentin Derangère, Mickaël Rialland, Laurent Arnould, Alexia Karen Cotte, Cédric Rébé

Publikováno v: Oncotarget

Increasing evidence indicates that Liver X Receptors (LXRs) have some anticancer properties. We recently demonstrated that LXR ligands induce colon cancer cell pyroptosis through an LXRβ-dependent pathway. In the present study, we showed that human

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::467120fcc9cb8a283f417aec0ffa89dc
https://doi.org/10.18632/oncotarget.5791

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Importance of lipid microdomains, rafts, in absorption, delivery, and biological effects of resveratrol

Autor: Emeric Limagne, François Ghiringhelli, Virginie Aires, Alessandra Scagliarini, Didier J. Colin, Alexia Karen Cotte, Dominique Delmas

Publikováno v: Annals of the New York Academy of Sciences. 1290:90-97

The preventive effects of the phytoalexin trans-resveratrol toward cancer have been largely described at the cellular and molecular levels in both in vivo and in vitro models; however, its primary targets are still poorly identified. In this review,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ebf9a68c41d0dc635ebb02662f1ba7d7
https://doi.org/10.1111/nyas.12177

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Potential role of oxidative DNA damage in the impact of PNPLA3 variant (rs 738409 CG) in hepatocellular carcinoma risk

Autor: Emeric Limagne, Alexia Karen Cotte, Patrick Hillon, Norbert Latruffe, Samia Hamza, Dominique Delmas, Vanessa Cottet

Publikováno v: Hepatology
Hepatology, Wiley-Blackwell, 2014, 60 (3), pp.1110-1111. ⟨10.1002/hep.27004⟩

International audience

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::564ea46f7b66d9166a00a3f85efb0f26
https://pubmed.ncbi.nlm.nih.gov/24425067

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Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death

Autor: Dominique Delmas, François Ghiringhelli, Alexia Karen Cotte, Virginie Aires, Norbert Latruffe, Emeric Limagne

Publikováno v: Molecular nutritionfood research. 57(7)

Scope Resveratrol (RSV) has been proposed to prevent tumor growth; nevertheless, these preventive effects are controversial since RSV pharmacokinetics studies show a low bioavailability. Recent clinical trials show that patients with colorectal cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::687fca9ce8f5c6e23445a19bb76d4d1c
https://pubmed.ncbi.nlm.nih.gov/23495229

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