Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Alexia Hervieu"'
Autor:
Alexia Hervieu, Stéphanie Kermorgant
Publikováno v:
Molecular & Cellular Oncology, Vol 7, Iss 6 (2020)
We reported that RAC1 is a master regulator of cell migration and anchorage-independent growth, downstream of the oncogenic Receptor Tyrosine Kinase (RTK) MET. RAC1 growth-promoting role is guanosine triphosphatase (GTPase)- and phosphatidylinositol
Externí odkaz:
https://doaj.org/article/3457d5060cc24d60bbaaae6b6ff4ea22
Autor:
Rachel Barrow-McGee, Naoki Kishi, Carine Joffre, Ludovic Ménard, Alexia Hervieu, Bakhouche A. Bakhouche, Alejandro J. Noval, Anja Mai, Camilo Guzmán, Luisa Robbez-Masson, Xavier Iturrioz, James Hulit, Caroline H. Brennan, Ian R. Hart, Peter J. Parker, Johanna Ivaska, Stéphanie Kermorgant
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
Cooperative signalling between receptor tyrosine kinases (RTKs) and integrins is thought to occur at the cell surface. Here the authors show that β1 integrin influences signalling of an RTK, c-Met, from a novel intracellular compartment they call au
Externí odkaz:
https://doaj.org/article/452ea8b8d9b2466d9eb39259519916df
Autor:
Alexia Hervieu, Stéphanie Kermorgant
Publikováno v:
Frontiers in Molecular Biosciences, Vol 5 (2018)
The Receptor Tyrosine Kinase (RTK) Met, overexpressed or mutated in cancer, plays a major role in cancer progression and represents an attractive target for cancer therapy. However RTK inhibitors can lead to drug resistance, explaining the necessity
Externí odkaz:
https://doaj.org/article/a3facb48bf1d407a865077f69bb323d3
Autor:
Rahul S. Samant, Silvia Batista, Mark Larance, Bugra Ozer, Christopher I. Milton, Isabell Bludau, Estelle Wu, Laura Biggins, Simon Andrews, Alexia Hervieu, Harvey E. Johnston, Bissan Al-Lazikhani, Angus I. Lamond, Paul A. Clarke, Paul Workman
Publikováno v:
Molecularcellular proteomics : MCP.
The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of HSP90 have been observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0904af941dabe05cfa40fc268d8dd4e4
https://pubmed.ncbi.nlm.nih.gov/36549590
https://pubmed.ncbi.nlm.nih.gov/36549590
Autor:
Rahul S. Samant, Silvia Batista, Mark Larance, Bugra Ozer, Christopher I. Milton, Isabell Bludau, Laura Biggins, Simon Andrews, Alexia Hervieu, Harvey E. Johnston, Bissan Al-Lazikhani, Angus I. Lamond, Paul A. Clarke, Paul Workman
The molecular chaperone heat shock protein 90 (HSP90) works in concert with co-chaperones to stabilize its client proteins, which include multiple drivers of oncogenesis and malignant progression. Pharmacologic inhibitors of HSP90 have been observed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6b072aed1f9bd03dd78387065dbf1cad
https://doi.org/10.1101/2022.05.23.492985
https://doi.org/10.1101/2022.05.23.492985
Autor:
Chi Zhang, Yu-jing Lu, Bingjie Chen, Zhiyan Bai, Alexia Hervieu, Marco P. Licciardello, Mei Wang, Costas Mitsopoulos, Bissan Al-Lazikani, Marcello Totorici, Olivia W. Rossanese, Paul Workman, Paul A. Clarke
Publikováno v:
SSRN Electronic Journal.
SummaryEstrogen receptor (ER) activation results in the formation of DNA double strand breaks (DSB), which promote genomic instability and tumour heterogeneity in ER-positive breast cancers. The single-stranded DNA (ssDNA) cytosine deaminase APOBEC3B
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7096ae4451f566759c6b3299b6cb01b
https://doi.org/10.2139/ssrn.4292602
https://doi.org/10.2139/ssrn.4292602
Autor:
Rachel Barrow-McGee, Naoki Kishi, Carine Joffre, Ludovic Ménard, Alexia Hervieu, Bakhouche A. Bakhouche, Alejandro J. Noval, Anja Mai, Camilo Guzmán, Luisa Robbez-Masson, Xavier Iturrioz, James Hulit, Caroline H. Brennan, Ian R. Hart, Peter J. Parker, Johanna Ivaska, Stéphanie Kermorgant
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications 7 Article number:11942 (2016); Published 23 June 2016; Updated 21 July 2016 The original version of this Article contained an error in the spelling of the author Luisa Robbez-Masson, which was incorrectly given as Luisa Robert-M
Externí odkaz:
https://doaj.org/article/f865856d240348fba98e76cb68ca0162
Autor:
Carine Joffre, Paul A. Clarke, Chi Zhang, Sara Farrah Heuss, Alexia Hervieu, Stéphanie Kermorgant, Ludovic Ménard, Rachel Barrow-McGee
Publikováno v:
Sci Signal
Receptor tyrosine kinases (RTKs) are often overexpressed or mutated in cancers and drive tumor growth and metastasis. In the current model of RTK signaling, including that of the RTK MET, downstream phosphoinositide 3-kinase (PI3K) mediates both cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8b43c1841927b73aaa374756618346
https://pubmed.ncbi.nlm.nih.gov/32576681
https://pubmed.ncbi.nlm.nih.gov/32576681
Autor:
James Hulit, Johanna Ivaska, Alejandro J. Noval, Camilo Guzmán, Ian R. Hart, Rachel Barrow-McGee, Xavier Iturrioz, Caroline H. Brennan, Stéphanie Kermorgant, Naoki Kishi, Bakhouche A. Bakhouche, Ludovic Ménard, Carine Joffre, Luisa Robbez-Masson, Alexia Hervieu, Peter J. Parker, Anja Mai
Publikováno v:
Nature Communications
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Nature Communications, Vol 7, Iss 1, Pp 1-1 (2016)
Receptor tyrosine kinases (RTKs) and integrins cooperate to stimulate cell migration and tumour metastasis. Here we report that an integrin influences signalling of an RTK, c-Met, from inside the cell, to promote anchorage-independent cell survival.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8cf326930c6f2fb0e57d3b22c9e698f9
https://pubmed.ncbi.nlm.nih.gov/27336951
https://pubmed.ncbi.nlm.nih.gov/27336951
Autor:
Jean-Baptiste Michel, Elisabeth Corvazier, Dominique Pidard, Alexia Hervieu, Christine Choqueux, Sophie de Bentzmann, Liliane Louedec, Anne Cady, Michael Dussiot, Nathalie Beaufort
Publikováno v:
Cellular Microbiology. 13:1149-1167
Disruption of cell/ECM interactions resulting from uncontrolled pericellular proteolysis leads to detachment-induced cell apoptosis (anoikis), contributing to the morbid evolution of inflammatory vascular diseases. During cardiovascular infections, b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a2fb2103b3b44b5490154044ff6c37c
https://doi.org/10.1111/j.1462-5822.2011.01606.x
https://doi.org/10.1111/j.1462-5822.2011.01606.x