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of 5
pro vyhledávání: '"Alexia Grangeon"'
Autor:
Alexia Grangeon, Valérie Clermont, Azemi Barama, Fleur Gaudette, Jacques Turgeon, Veronique Michaud
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 23, p 12791 (2021)
The human small intestine can be involved in the first-pass metabolism of drugs. Under this condition, members of the CYP450 superfamily are expected to contribute to drug presystemic biotransformation. The aim of this study was to quantify protein e
Externí odkaz:
https://doaj.org/article/2646f38f203e4d44adfdaf65626793bd
Autor:
Fleur Gaudette, Véronique Michaud, Azemi Barama, Alexia Grangeon, Jacques Turgeon, Valérie Clermont
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12791
International Journal of Molecular Sciences, Vol 22, Iss 12791, p 12791 (2021)
International Journal of Molecular Sciences; Volume 22; Issue 23; Pages: 12791
International Journal of Molecular Sciences, Vol 22, Iss 12791, p 12791 (2021)
The human small intestine can be involved in the first-pass metabolism of drugs. Under this condition, members of the CYP450 superfamily are expected to contribute to drug presystemic biotransformation. The aim of this study was to quantify protein e
Autor:
Valérie Clermont, Veronique Michaud, Alexia Grangeon, Jacques Turgeon, Michel Lallier, Azemi Barama, Jacques Malaise
Publikováno v:
Br J Clin Pharmacol
Aims To characterize mRNA expression levels (17 cytochromes P450) and activity (9 isoforms) of major cytochromes P450 expressed throughout the human small intestine. Methods Tissue samples were obtained from 9 deceased subjects and intestinal section
Publikováno v:
Journal of Chromatography B. 1040:144-158
Cocktails composed of several Cytochrome P450 (CYP450)-selective probe drugs have been shown of value to characterize in vivo drug-metabolism activities. Our objective was to develop and validate highly sensitive and selective LC-MS/MS assays allowin
Publikováno v:
Clinical pharmacology and therapeutics. 106(6)
We conducted a comprehensive in vivo study evaluating the influence of type 2 diabetes (T2D) on major cytochrome P450 (CYP450) activities. These activities were assessed in 38 T2D and 35 non-T2D subjects after a single oral administration of a cockta