Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis

Autor: Ioannis D. Kyrochristos, Georgios K. Glantzounis, Anna Goussia, Alexia Eliades, Achilleas Achilleos, Kyriakos Tsangaras, Irene Hadjidemetriou, Marilena Elpidorou, Marios Ioannides, George Koumbaris, Michail Mitsis, Philippos C. Patsalis, Dimitrios Roukos

Publikováno v: Frontiers in Oncology, Vol 12 (2022)

IntroductionThe mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood.ObjectiveWe evaluate the potential translational impl

Externí odkaz: https://doaj.org/article/6c2e9e360b214662b6d27ac42404d714

Molecular profile and clinical features of patients with gliomas using a broad targeted next generation-sequencing panel

Autor: Ourania Romanidou, Paraskevi Apostolou, Kyriakos Kouvelakis, Kyriakos Tsangaras, Alexia Eliades, Achilleas Achilleos, Charalambos Loizides, Christos Lemesios, Marios Ioannides, Elena Kypri, George Koumbaris, Kyriaki Papadopoulou, Athanasios Papathanasiou, Georgios Rigakos, Ioannis Xanthakis, Florentia Fostira, Vassiliki Kotoula, George Fountzilas, Philippos Patsalis

Publikováno v: Oncol Lett

Gliomas are the most common malignant primary brain tumors characterized by poor prognosis. The genotyping of tumors using next generation sequencing (NGS) platforms enables the identification of genetic alterations that constitute diagnostic, progno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ca29322205c134cd198ebfb1e03b5f1
https://europepmc.org/articles/PMC9773316/

Proof-of-Concept Pilot Study on Comprehensive Spatiotemporal Intra-Patient Heterogeneity for Colorectal Cancer With Liver Metastasis

Autor: Georgios K. Glantzounis, Philippos C. Patsalis, Marios Ioannides, Ioannis D Kyrochristos, Irene Hadjidemetriou, Kyriakos Tsangaras, Anna Goussia, Marilena Elpidorou, George Koumbaris, Michail Mitsis, Achilleas Achilleos, Alexia Eliades, Dimitrios H Roukos

Publikováno v: Frontiers in Oncology. 12

PurposeThe mechanisms underlying high drug resistance and relapse rates after multi-modal treatment in patients with colorectal cancer (CRC) and liver metastasis (LM) remain poorly understood. We evaluate the potential translational implications of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c1b572014f123a49863a03eca21c8a4
https://doi.org/10.3389/fonc.2022.855463

SO-2 Prevalence and prognostic role of inherited germline mutations in cancer predisposing genes in unselected patients with pancreatic cancer

Autor: Georgios Rigakos, Achilleas Achilleos, Maria Theochari, C. Papadimitriou, Gerassimos Aravantinos, Georgios Oikonomopoulos, Philippos C. Patsalis, Adamantia Nikolaidi, Pavlos Papakostas, Anna Koumarianou, Christos Dervenis, P. Kosmidis, Georgios Zarkavelis, Elena Fountzilas, A. Psyrri, Athina Christopoulou, Alexia Eliades, Konstantinos Ferentinos, Georgia-Angeliki Koliou, D.G. Pectasides, G. Fountzilas, Joseph Sgouros

Publikováno v: Annals of Oncology. 31:S217

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b3f66c066a2a14faf65196073e63d310
https://doi.org/10.1016/j.annonc.2020.04.017

Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes

Autor: Mairi Shepherd, Julie A. I. Thoms, Kathy Knezevic, Ashwin Unnikrishnan, Rahul Roychoudhuri, Berthold Göttgens, Thomas E. Willnow, Roshana Thambyrajah, Aileen M. Smith, George Lacaud, Julia Klippert, Parham Solaimani, Alexia Eliades, Rabab Nasrallah, Dominik Beck, Elaine Dzierzak, John E. Pimanda, Leonard I. Zon, Jason W. H. Wong, Annette Hammes, Eva M. Fast, Fabian Paul, Chris S. Vink, Valerie Kouskoff, David G. Kent, Rahima Patel

Publikováno v: Blood, 128(15), 1928-1939. American Society of Hematology
Nasrallah, R, Fast, E M, Solaimani, P, Knezevic, K, Eliades, A, Patel, R, Thambyrajah, R, Unnikrishnan, A, Thoms, J, Beck, D, Vink, C S, Smith, A, Wong, J, Shepherd, M, Kent, D, Roychoudhuri, R, Paul, F, Klippert, J, Hammes, A, Willnow, T, Göttgens, B, Dzierzak, E, Zon, L I, Lacaud, G, Kouskoff, V & Pimanda, J E 2016, ' Identification of novel regulators of developmental hematopoiesis using endoglin regulatory elements as molecular probes ', Blood, vol. 128, no. 15, pp. 1928-1939 . https://doi.org/10.1182/blood-2016-02-697870
Nasrallah, R, Fast, E M, Solaimani, P, Knezevic, K, Eliades, A, Patel, R, Thambyrajah, R, Unnikrishnan, A, Thoms, J, Beck, D, Vink, C S, Smith, A, Wong, J, Shepherd, M, Kent, D, Roychoudhuri, R, Paul, F, Klippert, J, Hammes, A, Willnow, T, Göttgens, B, Dzierzak, E, Zon, L I, Lacaud, G, Kouskoff, V & Pimanda, J E 2016, ' Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes ', Blood, vol. 128, no. 15, pp. 1928-1939 . https://doi.org/10.1182/blood-2016-02-697870
Scopus-Elsevier

© 2016 by The American Society of Hematology. Enhancers are the primary determinants of cell identity, and specific promoter/enhancer combinations of Endoglin (ENG) have been shown to target blood and endothelium in the embryo. Here, we generated a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07213fc598a2ad30f32274793d522e7