Výsledky vyhledávání - "Alexia Abecassis"

Akademický článek

Heparanase contributes to pancreatic carcinoma progression through insulin-dependent glucose uptake

Autor: Alexia Abecassis, Esther Hermano, Adi Yifrach, Aron Popovtzer, Amichay Meirovitz, Michael Elkin

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 11 (2023)

Pancreatic ductal adenocarcinoma (PDAC) is an aggressive tumor, which is highly resistant to existing therapies and characterized by one of the lowest survival rates known for solid cancers. Among the reasons for this poor prognosis are unique pathop

Externí odkaz: https://doaj.org/article/4d3661c6891747da8571cd2c3506585d

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Akademický článek

Radiation-Induced Nephropathy in the Murine Model Is Ameliorated by Targeting Heparanase

Autor: Alexia Abecassis, Esther Hermano, Kim Sheva, Ariel M. Rubinstein, Michael Elkin, Amichay Meirovitz

Publikováno v: Biomedicines, Vol 11, Iss 3, p 710 (2023)

Agents used to reduce adverse effects common in cancer treatment modalities do not typically possess tumor-suppressing properties. We report that heparanase, an extracellular matrix-degrading enzyme, is a promising candidate for preventing radiation

Externí odkaz: https://doaj.org/article/5c0c1cee3d764917825166a721740020

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Akademický článek

Regulation of Heparanase in Diabetes-Associated Pancreatic Carcinoma

Autor: Rachel Goldberg, Amichay Meirovitz, Alexia Abecassis, Esther Hermano, Ariel M. Rubinstein, Daniela Nahmias, Albert Grinshpun, Tamar Peretz, Michael Elkin

Publikováno v: Frontiers in Oncology, Vol 9 (2019)

While at least six types of cancer have been associated with diabetes, pancreatic ductal adenocarcinoma (PDAC) and diabetes exhibit a unique bidirectional relationship. Recent reports indicate that majority of PDAC patients display hyperglycemia, and

Externí odkaz: https://doaj.org/article/cc452a2b51dd4ba49b624a298f99b89e

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Dichotomic role of heparanase in a murine model of metabolic syndrome

Autor: Michael Elkin, Esther Hermano, Amichay Meirovitz, Ariel Rubinstein, Israel Vlodavsky, Jin-Ping Li, Ton J. Rabelink, Françoise Carlotti, Alexia Abecassis

Publikováno v: Cellular and Molecular Life Sciences. SPRINGER BASEL AG
Cellular and Molecular Life Sciences

Heparanase is the predominant enzyme that cleaves heparan sulfate, the main polysaccharide in the extracellular matrix. While the role of heparanase in sustaining the pathology of autoimmune diabetes is well documented, its association with metabolic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2829ebd73299c09641e8bdddbcfa8a0
https://hdl.handle.net/1887/3184948