Výsledky vyhledávání - "Alexia, Buzzonetti"

Akademický článek

Stat1 confers sensitivity to radiation in cervical cancer cells by controlling Parp1 levels: a new perspective for Parp1 inhibition

Autor: Giuseppina Raspaglio, Marianna Buttarelli, Flavia Filippetti, Alessandra Battaglia, Alexia Buzzonetti, Giovanni Scambia, Daniela Gallo

Publikováno v: Cell Death and Disease, Vol 12, Iss 10, Pp 1-13 (2021)

Abstract Cervical cancer (CC) is the fourth most common cause of cancer-related death in women. According to international guidelines, a standard treatment for locally advanced cervical cancer (LACC) consists of exclusive concurrent chemoradiation tr

Externí odkaz: https://doaj.org/article/41e997f424444c508b4e64c93597c203

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PD-L1 Expression on Circulating Tumour-Derived Microvesicles as a Complementary Tool for Stratification of High-Grade Serous Ovarian Cancer Patients

Autor: Giovanni Scambia, Marco Fossati, Giuseppe Angelico, Veronica Iannucci, Nicole Zampetti, Valentina Iacobelli, Anna Fagotti, Andrea Fattorossi, Tina Pasciuto, Alessia Piermattei, Alessandra Battaglia, Camilla Nero, Alexia Buzzonetti

Publikováno v: Cancers
Cancers, Vol 13, Iss 5200, p 5200 (2021)
Volume 13
Issue 20

Simple Summary PD-1/PD-L1 axis blockade immunotherapy leverages on assessment of tumour PD-L1 status by immunohistochemistry for identifying cancer patients’ who would benefit most from this therapy. Because some PD-L1 negative cancer patients also

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c6e71631516709e2b682fae38ae816
https://pubmed.ncbi.nlm.nih.gov/34680346

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The BET Inhibitor OTX015 Exhibits In Vitro and In Vivo Antitumor Activity in Pediatric Ependymoma Stem Cell Models

Autor: Alexia Buzzonetti, Gabriele Babini, Giovanni Scambia, Alessandra Battaglia, Luca Massimi, Antonio Ruggiero, Alessia Granitto, Maurizio Martini, Gianpiero Tamburrini, Daniela Meco, Tiziana Servidei, Riccardo Riccardi

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 4
International Journal of Molecular Sciences, Vol 22, Iss 1877, p 1877 (2021)

Childhood ependymomas are heterogenous chemoresistant neoplasms arising from aberrant stem-like cells. Epigenome deregulation plays a pivotal role in ependymoma pathogenesis, suggesting that epigenetic modifiers hold therapeutic promise against this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::162b5c3676a527296851283496c67529
https://hdl.handle.net/10807/223485

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A robust immune system conditions the response to abagovomab (anti-idiotypic monoclonal antibody mimicking the CA125 protein) vaccination in ovarian cancer patients

Autor: Giovanni Scambia, Alexia Buzzonetti, Andrea Fattorossi, Marco Fossati, Alessandra Battaglia

Introduction Despite encouraging phase I and II study results, vaccination of ovarian cancer patients with abagovomab – an anti-idiotypic mAb that mimics the ovarian cancer CA125 protein – failed to demonstrate efficacy in the phase III trial nam

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69e9e433bda7ed7317423f9be1e8fd34
http://hdl.handle.net/10807/111940

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Immunological response induced by abagovomab as a maintenance therapy in patients with epithelial ovarian cancer: relationship with survival—a substudy of the MIMOSA trial

Autor: Alessandra Battaglia, Giovanni Scambia, Alexia Buzzonetti, Andrea Fattorossi, Marco Fossati, Valentina Catzola

Publikováno v: Cancer Immunology, Immunotherapy. 63:1037-1045

To determine whether abagovomab induces protective immune responses in ovarian cancer patients in first clinical remission. The present analysis is a substudy of monoclonal antibody immunotherapy for malignancies of the ovary by subcutaneous abagovom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34573704b8f0547ab8be5486105dac72
https://doi.org/10.1007/s00262-014-1569-0

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Interleukin-21 (IL-21) synergizes with IL-2 to enhance T-cell receptor-induced human T-cell proliferation and counteracts IL-2/transforming growth factor-β-induced regulatory T-cell development

Autor: Giovanni Scambia, Alessandra Battaglia, Mara Fanelli, Alexia Buzzonetti, Cinzia Baranello, Andrea Fattorossi, Marco Fossati, Valentina Catzola

Publikováno v: Immunology. 139:109-120

Interleukin-2 (IL-2) is a mainstay for current immunotherapeutic protocols but its usefulness in patients is reduced by severe toxicities and because IL-2 facilitates regulatory T (Treg) cell development. IL-21 is a type I cytokine acting as a potent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::142bc7414fc5dd933b28d287eed3a986
https://doi.org/10.1111/imm.12061

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Selective Changes in the Immune Profile of Tumor-Draining Lymph Nodes After Different Neoadjuvant Chemoradiation Regimens for Locally Advanced Cervical Cancer

Autor: Giovanni Scambia, Alexia Buzzonetti, Mara Fanelli, Andrea Fattorossi, Alessandra Battaglia, Marco Petrillo, Enrica Martinelli, Gabriella Ferrandina

Publikováno v: International Journal of Radiation Oncology*Biology*Physics. 76:1546-1553

Purpose To assess how neoadjuvant chemoradiation regimens modulate the immune system state in tumor-draining lymph nodes (TDLN), in the setting of advanced cervical cancer. Methods and Materials Tumor-draining lymph nodes of patients undergoing chemo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f354f90968f741f4234889c15d16c280
https://doi.org/10.1016/j.ijrobp.2009.10.014

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Metastatic tumour cells favour the generation of a tolerogenic milieu in tumour draining lymph node in patients with early cervical cancer

Autor: Giovanni Scambia, Gabriella Ferrandina, Enrica Martinelli, Cinzia Baranello, Francesco Fanfani, Andrea Fattorossi, Alexia Buzzonetti, Alessandra Battaglia

Publikováno v: Cancer Immunology, Immunotherapy. 58:1363-1373

We compared the immune system state in metastatic tumour draining lymph nodes (mTDLN) and metastasis free TDLN (mfTDLN) in 53 early stage cervical cancer patients to assess whether the presence of metastatic tumour cells worsen the balance between an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bac28347dd500c46674da35885d331a
https://doi.org/10.1007/s00262-008-0646-7

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