Data from Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites

Autor: David M. Waisman, Paul A. O'Connell, Alexi P. Surette, Kyle D. Phipps

Macrophages are critical drivers of tumor growth, invasion, and metastasis. Movement of macrophages into tumors requires the activity of cell surface proteases such as plasmin. In this study, we offer genetic evidence that plasminogen receptor S100A1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::80917e15e3da1bfaa80028d6489f5d20
https://doi.org/10.1158/0008-5472.c.6502850.v1

Supplementary Figure 1 from Plasminogen Receptor S100A10 Is Essential for the Migration of Tumor-Promoting Macrophages into Tumor Sites

Autor: David M. Waisman, Paul A. O'Connell, Alexi P. Surette, Kyle D. Phipps

PDF file - 538K

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86ed04623daa1de58dd9ba459b320dc7
https://doi.org/10.1158/0008-5472.22390157

Using Deep Learning to Predict Final HER2 Status in Invasive Breast Cancers That are Equivocal (2+) by Immunohistochemistry

Autor: Sean A. Rasmussen, Valerie J. Taylor, Alexi P. Surette, Penny J. Barnes, Gillian C. Bethune

Publikováno v: Applied immunohistochemistrymolecular morphology : AIMM. 30(10)

Invasive breast carcinomas are routinely tested for HER2 using immunohistochemistry (IHC), with reflex in situ hybridization (ISH) for those scored as equivocal (2+). ISH testing is expensive, time-consuming, and not universally available. In this st

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052dfd89f58d38127e9ddbf13575f1d7
https://pubmed.ncbi.nlm.nih.gov/36251973

ErbB2-driven downregulation of the transcription factor Irf6 in breast epithelial cells is required for their 3D growth

Autor: Gillian Bethune, Byong Hoon Yoo, Alexi P. Surette, Kirill V. Rosen, Michael McPhee, Kelly Dakin-Hache, Olivier Masson, Tallal Younis, Iman Aftab Khan

Publikováno v: Breast Cancer Research, Vol 20, Iss 1, Pp 1-14 (2018)
Breast Cancer Research : BCR

Background The ability of solid tumor cells to resist anoikis, apoptosis triggered by cell detachment from the extracellular matrix (ECM), is thought to be critical for 3D tumor growth. ErbB2/Her2 oncoprotein is often overproduced by breast tumor cel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddb4230947f2d55b492a90b5e420be6a
http://link.springer.com/article/10.1186/s13058-018-1080-1

The Biochemistry and Regulation of S100A10: A Multifunctional Plasminogen Receptor Involved in Oncogenesis

Autor: Alexi P. Surette, Patricia A. Madureira, David M. Waisman, Paul A. O'Connell, Victoria A Miller

Publikováno v: Journal of Biomedicine and Biotechnology
Journal of Biomedicine and Biotechnology, Vol 2012 (2012)
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP

The plasminogen receptors mediate the production and localization to the cell surface of the broad spectrum proteinase, plasmin. S100A10 is a key regulator of cellular plasmin production and may account for as much as 50% of cellular plasmin generati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75237b501db474241d4d12a6568ee22d
https://doi.org/10.1155/2012/353687