Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Alexi K. Alekov"'
Autor:
Daniel Wojciechowski, Elena Kovalchuk, Lan Yu, Hua Tan, Christoph Fahlke, Gabriel Stölting, Alexi K. Alekov
Publikováno v:
Frontiers in Physiology, Vol 9 (2018)
Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl-/H+ antiporter ClC-5. The disease typically manifests with proteinuria, hypercalciuria, nephrocalcinosis, and nephrolithiasis but is characterized by large p
Externí odkaz:
https://doaj.org/article/8cc75c50fb8c43b8bc957d29489f4b27
Autor:
Alexi K. Alekov, Rosa Vargas-Poussou, Georges Deschênes, Yohan Bignon, Nadia Frachon, Olivier Lahuna, Stéphane Lourdel, Carine Jean-Baptiste Doh-Egueli
Publikováno v:
Human Mutation
Human Mutation, Wiley, 2018, 39 (8), pp.1139-1149. ⟨10.1002/humu.23556⟩
Human Mutation, Wiley, 2018, 39 (8), pp.1139-1149. ⟨10.1002/humu.23556⟩
International audience; Dent disease is an X‐linked recessive renal tubular disorder characterized by low‐molecular‐weight proteinuria, hypercalciuria, nephrolithiasis, nephrocalcinosis, and progressive renal failure. Inactivating mutations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::354d7b088d366bbddfd2dd0300081e56
https://doi.org/10.1002/humu.23556
https://doi.org/10.1002/humu.23556
Autor:
Katharina Langschwager, Alexi K. Alekov, Raul E. Guzman, Christoph Fahlke, Matthias Grieschat
Publikováno v:
EMBO reports 21(6), e47872 (2020). doi:10.15252/embr.201947872
EMBO Reports
EMBO Reports
CLC anion/proton exchangers control the pH and [Cl−] of the endolysosomal system that is essential for cellular nutrient uptake. Here, we use heterologous expression and whole‐cell electrophysiology to investigate the regulation of the CLC isofor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc6b1955feda8c7a3e536f4df479b66
Autor:
Alexi K. Alekov, Gabriel Stölting, Elena Kovalchuk, Christoph Fahlke, Hua Tan, Daniel Wojciechowski, Lan Yu
Publikováno v:
Frontiers in Physiology
Frontiers in physiology 9, 1490 (2018). doi:10.3389/fphys.2018.01490
Frontiers in Physiology, Vol 9 (2018)
Frontiers in physiology 9, 1490 (2018). doi:10.3389/fphys.2018.01490
Frontiers in Physiology, Vol 9 (2018)
Dent disease 1 (DD1) is a renal salt-wasting tubulopathy associated with mutations in the Cl-/H+ antiporter ClC-5. The disease typically manifests with proteinuria, hypercalciuria, nephrocalcinosis, and nephrolithiasis but is characterized by large p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd04fdc1dd44139a86839c79f21aa98
http://europepmc.org/articles/PMC6206076
http://europepmc.org/articles/PMC6206076
Autor:
Klemens Rottner, Helma Tatge, Alexandra Olling, Ralf Gerhard, Sebastian Goy, Nicole Reich, Alexi K. Alekov, Lara-Antonia Beer, Michel Tenspolde
Publikováno v:
Cellular microbiology
Toxin A and Toxin B (TcdA/TcdB) are large glucosyltransferases produced by Clostridium difficile. TcdB but not TcdA induces reactive oxygen species-mediated early cell death (ECD) when applied at high concentrations. We found that nonglucosylated Rac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b5341f0352c79b247f71d804bd61d16
https://pubmed.ncbi.nlm.nih.gov/29904993
https://pubmed.ncbi.nlm.nih.gov/29904993
Autor:
Alexi K. Alekov, Matthias Grieschat
Publikováno v:
Biophysical Journal. 107(6):L13-L15
Most mammalian chloride channels and transporters in the CLC family display pronounced voltage-dependent gating. Surprisingly, despite the complex nature of the gating process and the large contribution to it by the transport substrates, experimental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3f0bde99acf55d2233d73ae6a4f700
Autor:
Patricia Hidalgo, Mohammad Reza Boroumand, Christoph Fahlke, Birgit Begemann, Alexi K. Alekov, Jennie Garcia-Olivares
Publikováno v:
The Journal of Physiology. 586:5325-5336
Eukaryotic ClC channels are dimeric proteins with each subunit forming an individual protopore. Single protopores are gated by a fast gate, whereas the slow gate is assumed to control both protopores through a cooperative movement of the two carboxy-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27bacd19c264f2ba5bbcf3560ca3ed10
https://doi.org/10.1113/jphysiol.2008.158097
https://doi.org/10.1113/jphysiol.2008.158097
Autor:
Alexi K. Alekov
Publikováno v:
Frontiers in Physiology, Vol 6 (2015)
Frontiers in Physiology
Frontiers in Physiology
Dent’s disease is associated with impaired renal endocytosis and endosomal acidification. It is linked to mutations in the membrane chloride/proton exchanger ClC-5, however, a direct link between localization in the protein and functional phenotype
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3d6308d31780508130590c23f245ef7
http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00159/full
http://journal.frontiersin.org/Journal/10.3389/fphys.2015.00159/full
Publikováno v:
The Journal of Physiology. 561:39-51
Cytoplasmic S4‐S5 loops have been shown to be involved in fast inactivation of voltagegate di on channels. We studied mutations in these loops and their potential cooperative effects in domains D3 (N1151C, A1152C, I1160C/A) and D4 (F1473C, L1482C/A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cad3b32580abcf2b7cce5b1951db120a
https://doi.org/10.1113/jphysiol.2004.065912
https://doi.org/10.1113/jphysiol.2004.065912
Autor:
Alexi K. Alekov, Christian Lerche, Guiscard Seebohm, Snezana Maljevic, Holger Lerche, Andreas E. Busch
Publikováno v:
The Journal of Physiology. 548:353-360
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6c3ec46c81432b82c1e0eedb124d455
https://doi.org/10.1111/j.1469-7793.2003.00353.x
https://doi.org/10.1111/j.1469-7793.2003.00353.x