Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Alexey Zakharov"'
Autor:
Debasish Paul, Stephen C. Kales, James A. Cornwell, Marwa M. Afifi, Ganesha Rai, Alexey Zakharov, Anton Simeonov, Steven D. Cappell
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
β-TrCP plays an important role in diverse cellular processes such as the cell cycle and inflammation. Here the authors develop a biosensor for β-TrCP activity and use it to investigate β-TrCP dynamics during the cell cycle, and to screen a small-m
Externí odkaz:
https://doaj.org/article/415e09b495e74ee7996f1b99655e2bf4
Development of an improved and specific inhibitor of NADPH oxidase 2 to treat traumatic brain injury
Autor:
Hannah Mason, Ganesha Rai, Arina Kozyr, Nathaniel De Jonge, Emily Gliniewicz, Lars J. Berg, Gal Wald, Cayce Dorrier, Mark J. Henderson, Alexey Zakharov, Tristan Dyson, John Audley, Anthony M. Pettinato, Elias Carvalho Padilha, Pranav Shah, Xin Xu, Thomas L. Leto, Anton Simeonov, Kol A. Zarember, Dorian B. McGavern, John I. Gallin
Publikováno v:
Redox Biology, Vol 60, Iss , Pp 102611- (2023)
NADPH oxidases (NOX's), and the reactive oxygen species (ROS) they produce, play an important role in host defense, thyroid hormone synthesis, apoptosis, gene regulation, angiogenesis and other processes. However, overproduction of ROS by these enzym
Externí odkaz:
https://doaj.org/article/31bbeff5a1be41638e89f840fa625181
Autor:
Eric Cheng, Dorjbal Dorjsuren, Stephanie Lehman, Charles L. Larson, Steven A. Titus, Hongmao Sun, Alexey Zakharov, Ganesha Rai, Robert A. Heinzen, Anton Simeonov, Matthias P. Machner
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Bacterial type IV secretion systems (T4SSs) are macromolecular machines that translocate effector proteins across multiple membranes into infected host cells. Loss of function mutations in genes encoding protein components of the T4SS render
Externí odkaz:
https://doaj.org/article/17ea4c8ef25440e6a85c917d59465e91
Autor:
Rosita R. Asawa, Carina Danchik, Alexey Zakharov, Yuchi Chen, Ty Voss, Ajit Jadhav, Darren P. Wallace, Josephine F. Trott, Robert H. Weiss, Anton Simeonov, Natalia J. Martinez
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/9f53359cf9b545f888bec6295cf2f4f2
Autor:
Marielle Rath, James Wellnitz, Holli-Joi Martin, Cleber Melo-Filho, Joshua Hochuli, Guilherme Martins da Silva, Jon-Michael Beasley, Travis Maxfield, Zoe Sessions, Konstantin Popov, Alexey Zakharov, Artem Cherkasov, Vinicius Alves, Eugene Muratov, Alexander Tropsha
Computational models that predict PK properties, such as those related to drug absorption, metabolism, distribution, and excretion, are critical to flagging drug candidates with poor PK profiles that emerge as hits in high-throughput screening campai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e30dfd74488af335c17be2422dc43c9f
https://doi.org/10.26434/chemrxiv-2023-rnc4l
https://doi.org/10.26434/chemrxiv-2023-rnc4l
Autor:
Vinicius Alves, Adam Yasgar, James Wellnitz, Ganesha Bantukallu, Marielle Rath, Rodolpho Braga, Stephen Capuzzi, Anton Simeonov, Eugene Muratov, Alexey Zakharov, Alexander Tropsha
Hits from high-throughput screening (HTS) of chemical libraries are often false positives due to their interference with the assay detection technology. In response to this problem, we generated the largest publicly available library of chemical liab
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::173ad08e519d5b3f67df0b3ce38cb638
https://doi.org/10.26434/chemrxiv-2023-r78sj
https://doi.org/10.26434/chemrxiv-2023-r78sj
Analysis of method to increase the energy efficiency of squirrel cage induction motor of 200–1000 kW
Publikováno v:
2021 International Conference on Electrotechnical Complexes and Systems (ICOECS).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e500362421c91ecd7c69f4e7205d9397
https://doi.org/10.1109/icoecs52783.2021.9657366
https://doi.org/10.1109/icoecs52783.2021.9657366
Autor:
Eugene Muratov, Alexey Zakharov
The opportunities that may be provided by synergistic antiviral action of drugs for battling SARS-CoV2 are currently underestimated. Modern AI technologies realized as text, data, and knowledge mining and analytics tools provide the researchers with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::088185197deb7fcba195fce76fcd9fc6
https://doi.org/10.26434/chemrxiv.12143355.v1
https://doi.org/10.26434/chemrxiv.12143355.v1
Publikováno v:
Journal of Process Control. 63:15-28
Higher order statistics (HOS) have been widely adopted to diagnose the poor control loop performance in recent years. The existing HOS tools, including bispectrum, bicoherence and bicepstrum, can easily detect severe nonlinearity, but it is still an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38c18c248f7b6fa266e3b7d8e74b463
https://doi.org/10.1016/j.jprocont.2018.01.001
https://doi.org/10.1016/j.jprocont.2018.01.001
Publikováno v:
IEEE Transactions on Control Systems Technology. 25:769-780
Automatic detection of process faults requires process expertise to determine the fault symptoms and mathematical algorithms that can classify these symptoms correctly. Thus, the effectiveness of any automatic detection system can degrade because of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b52e4a85f21bae9a66c780a6879c2e
https://doi.org/10.1109/tcst.2016.2583959
https://doi.org/10.1109/tcst.2016.2583959