Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Alexey V Sarapulov"'
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Akademický článek
Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses
Autor: Alexey V. Sarapulov, Petar Petrov, Sara Hernández-Pérez, Vid Šuštar, Elina Kuokkanen, Lena Cords, Rufus V. M. Samuel, Marika Vainio, Marco Fritzsche, Yolanda R. Carrasco, Pieta K. Mattila
Publikováno v: Frontiers in Immunology, Vol 11 (2020)
Efficient generation of antibodies by B cells is one of the prerequisites of protective immunity. B cell activation by cognate antigens via B cell receptors (BCRs), or pathogen-associated molecules through pattern-recognition receptors, such as Toll-
Externí odkaz: https://doaj.org/article/3400b152011249b4b78cfb6d5632f6cc
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3
Loss of Rab8a in B cells leads to increased antibody responses and class-switch recombination
Autor: Sara Hernández-Pérez, Alexey V. Sarapulov, M. Özge Balci, Eleanor Coffey, Akihiro Harada, Pieta K. Mattila
Rab8a is a small GTPase with a wide range of reported functions in different cell types, including vesicle recycling, vesicle traffic to cilia, cell ruffling, migration, neurite outgrowth, Toll-like receptor signalling and T cell receptor docking at
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b1bfdb067490fd89313963dcaf40265
https://doi.org/10.1101/2022.09.19.508414
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4
BCR-induced protein dynamics and the emerging role of SUMOylation revealed by proximity proteomics
Autor: Marika Runsala, Luqman O Awoniyi, Alexey V. Sarapulov, Pieta K. Mattila, Vid Šuštar, Petar Petrov, Sara Hernández-Pérez
Successful B cell activation, critical for high-affinity antibody production, is controlled by the B cell antigen receptor (BCR). While the main components of the BCR signalling machinery are relatively well characterised, we still lack a comprehensi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::13f29d9e64814610506b88c55cb8fb79
https://doi.org/10.1101/2020.09.29.318766
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5
B cells rapidly target antigen and surface-derived MHCII into peripheral degradative compartments
Autor: Pieta K. Mattila, Alexey V. Sarapulov, Luqman O Awoniyi, Marika Vainio, J Rajala, V Paavola, Elina Kuokkanen, Eija Jokitalo, S Fórsten, Vid Šuštar, Andreas Bruckbauer, Helena Vihinen, Petar Petrov, Sara Hernández-Pérez
Publikováno v: Journal of Cell Science. 133
In order to mount high-affinity antibody responses, B cells internalise specific antigens and process them into peptides loaded onto MHCII for presentation to T helper cells (TH cells). While the biochemical principles of antigen processing and MHCII
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de78a47d4625e53b6dc93800773b0677
https://doi.org/10.1242/jcs.235192
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6
Missing-in-Metastasis/Metastasis Suppressor 1 Regulates B Cell Receptor Signaling, B Cell Metabolic Potential, and T Cell-Independent Immune Responses
Autor: Vid Šuštar, Petar Petrov, Yolanda R. Carrasco, Marco Fritzsche, Rufus V. M. Samuel, Elina Kuokkanen, Marika Vainio, Lena Cords, Alexey V. Sarapulov, Sara Hernández-Pérez, Pieta K. Mattila
Publikováno v: Frontiers in Immunology
Digital.CSIC. Repositorio Institucional del CSIC
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Frontiers in Immunology, Vol 11 (2020)
Efficient generation of antibodies by B cells is one of the prerequisites of protective immunity. B cell activation by cognate antigens via B cell receptors (BCRs), or pathogen-associated molecules through pattern-recognition receptors, such as Toll-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb255c8385487ebbf3569fdeb20b5489
https://pubmed.ncbi.nlm.nih.gov/32373113
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7
Missing-In-Metastasis / Metastasis Suppressor 1 regulates B cell receptor signaling, B cell metabolic potential and T cell-independent immune responses
Autor: Alexey V Sarapulov, Petar Petrov, Sara Hernández-Pérez, Vid Šuštar, Elina Kuokkanen, Rufus Vinod, Marika Vainio, Lena Cords, Marco Fritzsche, Yolanda R Carrasco, Pieta K Mattila
Efficient generation of antibodies by B cells is one of the prerequisites of protective immunity. B cells, activated by cognate antigens via B cell receptors (BCR) or pathogen-associated molecules through pattern-recognition receptors, such as TLRs,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff97f995e14e6c3f86b21def63dbe85d
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8
Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control
Autor: Petar Petrov, Alexey V. Sarapulov, Lel Eöry, Cristina Scielzo, Lydia Scarfò, Jacqueline Smith, David W. Burt, Pieta K. Mattila
Publikováno v: Petrov, P, Sarapulov, A V, Eory, L, Scielzo, C, Scarfo, L, Smith, J, Burt, D W & Mattila, P K 2019, ' Computational analysis of the evolutionarily conserved Missing In Metastasis/Metastasis Suppressor 1 gene predicts novel interactions, regulatory regions and transcriptional control ', Scientific Reports . https://doi.org/10.1038/s41598-019-40697-1
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-17 (2019)
Missing in Metastasis (MIM), or Metastasis Suppressor 1 (MTSS1), is a highly conserved protein, which links the plasma membrane to the actin cytoskeleton. MIM has been implicated in various cancers, however, its modes of action remain largely enigmat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::4f36f6b8cb5b4e182f84e8dd6c18ee3d
https://hdl.handle.net/20.500.11820/8b94429d-7907-42c7-8a43-d23104a686f9
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9
IRF4 Deficiency Leads to Altered BCR Signalling Revealed by Enhanced PI3K Pathway, Decreased SHIP Expression and Defected Cytoskeletal Responses
Autor: Alexey V. Sarapulov, Pieta K. Mattila, Minna Niemelä, Asta Laiho, Sini Junttila, Kalle-Pekka Nera, Jukka Alinikula, Minna K. Kyläniemi, Paulina Budzynska, Olli Lassila
Publikováno v: Scandinavian Journal of Immunology. 82:418-428
The graded expression of transcription factor interferon regulatory factor 4 (IRF4) regulates B cell development and is critical for plasma cell differentiation. However, the mechanisms, by which IRF4 elicits its crucial tasks, are largely unknown. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66d78613685290892d71f07572881281
https://doi.org/10.1111/sji.12343
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