Zobrazeno 1 - 10
of 167
pro vyhledávání: '"Alexey V Pshezhetsky"'
Autor:
Lorena Carvelli, Louis Hermo, Cristian O'Flaherty, Richard Oko, Alexey V Pshezhetsky, Carlos R Morales
Publikováno v:
PLoS ONE, Vol 18, Iss 9, p e0292157 (2023)
Heparan sulfate (HS), an abundant component of the apical cell surface and basement membrane, belongs to the glycosaminoglycan family of carbohydrates covalently linked to proteins called heparan sulfate proteoglycans. After endocytosis, HS is degrad
Externí odkaz:
https://doaj.org/article/04027ec3c5304f059135840c55ffd986
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0206173 (2018)
Mammalian neuraminidases are responsible for the removal of sialic acids from glycoproteins and glycolipids and function in a variety of biological phenomena such as lysosomal catabolism and control of cell differentiation and growth. Disruption of N
Externí odkaz:
https://doaj.org/article/6e3617bf5f6047dbb2d00d64d4408d53
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0172854 (2017)
Vasoactive and mitogenic peptide, endothelin-1 (ET-1) plays an important role in physiology of the ocular tissues by regulating the growth of corneal epithelial cells and maintaining the hemodynamics of intraocular fluids. We have previously establis
Externí odkaz:
https://doaj.org/article/8ad01cae92694c4ab4cf66615eada381
Autor:
Elizaveta Katorcha, Nina Klimova, Natallia Makarava, Regina Savtchenko, Xuefang Pan, Ida Annunziata, Kohta Takahashi, Taeko Miyagi, Alexey V Pshezhetsky, Alessandra d'Azzo, Ilia V Baskakov
Publikováno v:
PLoS ONE, Vol 10, Iss 11, p e0143218 (2015)
The central molecular event underlying prion diseases involves conformational change of the cellular form of the prion protein (PrPC), which is a sialoglycoprotein, into the disease-associated, transmissible form denoted PrPSc. Recent studies reveale
Externí odkaz:
https://doaj.org/article/f520cdeeb80445b8846673b7feed90cd
Autor:
Fadi F Hamdan, Myriam Srour, Jose-Mario Capo-Chichi, Hussein Daoud, Christina Nassif, Lysanne Patry, Christine Massicotte, Amirthagowri Ambalavanan, Dan Spiegelman, Ousmane Diallo, Edouard Henrion, Alexandre Dionne-Laporte, Anne Fougerat, Alexey V Pshezhetsky, Sunita Venkateswaran, Guy A Rouleau, Jacques L Michaud
Publikováno v:
PLoS Genetics, Vol 10, Iss 10, p e1004772 (2014)
Genetics is believed to have an important role in intellectual disability (ID). Recent studies have emphasized the involvement of de novo mutations (DNMs) in ID but the extent to which they contribute to its pathogenesis and the identity of the corre
Externí odkaz:
https://doaj.org/article/8c1a2d50896c473a8cc5a6e4147f3ac6
Autor:
Xuefang Pan, Lubov Grigoryeva, Volkan Seyrantepe, Junzheng Peng, Katrin Kollmann, Johanne Tremblay, Julie L Lavoie, Aleksander Hinek, Torben Lübke, Alexey V Pshezhetsky
Publikováno v:
PLoS Genetics, Vol 10, Iss 2, p e1004146 (2014)
The potent vasoconstrictor peptides, endothelin 1 (ET-1) and angiotensin II control adaptation of blood vessels to fluctuations of blood pressure. Previously we have shown that the circulating level of ET-1 is regulated through its proteolytic cleava
Externí odkaz:
https://doaj.org/article/a52a5f441dab48ebbd8044eab43b9068
Autor:
Victoria Smutova, Amgad Albohy, Xuefang Pan, Elena Korchagina, Taeko Miyagi, Nicolai Bovin, Christopher W Cairo, Alexey V Pshezhetsky
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106320 (2014)
The removal of sialic acid (Sia) residues from glycoconjugates in vertebrates is mediated by a family of neuraminidases (sialidases) consisting of Neu1, Neu2, Neu3 and Neu4 enzymes. The enzymes play distinct physiological roles, but their ability to
Externí odkaz:
https://doaj.org/article/d530e95bd42943088afd4f242855bc27
Autor:
Volkan Seyrantepe, Pablo Lema, Aurore Caqueret, Larbi Dridi, Samar Bel Hadj, Stephane Carpentier, Francine Boucher, Thierry Levade, Lionel Carmant, Roy A Gravel, Edith Hamel, Pascal Vachon, Graziella Di Cristo, Jacques L Michaud, Carlos R Morales, Alexey V Pshezhetsky
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001118 (2010)
Tay-Sachs disease is a severe lysosomal disorder caused by mutations in the HexA gene coding for the α-subunit of lysosomal β-hexosaminidase A, which converts G(M2) to G(M3) ganglioside. Hexa(-/-) mice, depleted of β-hexosaminidase A, remain asymp
Externí odkaz:
https://doaj.org/article/f14d9d3eff9a44e1970e7c4d0678171e
Publikováno v:
PLoS ONE, Vol 4, Iss 10, p e7434 (2009)
Mucopolysaccharidosis type IIIC or Sanfilippo syndrome type C (MPS IIIC, MIM #252930) is an autosomal recessive disorder caused by deficiency of the lysosomal membrane enzyme, heparan sulfate acetyl-CoA: alpha-glucosaminide N-acetyltransferase (HGSNA
Externí odkaz:
https://doaj.org/article/821f122a122c4b51bd70cb6053348d98
Autor:
Xuefang Pan, Antoine Caillon, Shuxian Fan, Shaukat Khan, Shunji Tomatsu, Alexey V. Pshezhetsky
Publikováno v:
Cells, Vol 13, Iss 10, p 877 (2024)
Mucopolysaccharidosis III type C (MPS IIIC) is an untreatable neuropathic lysosomal storage disease caused by a genetic deficiency of the lysosomal N-acetyltransferase, HGSNAT, catalyzing a transmembrane acetylation of heparan sulfate. HGSNAT is a tr
Externí odkaz:
https://doaj.org/article/fd13f0cf23ba4e43b07b59d0a19541e4