Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Alexey V Dvornikov"'
Autor:
Hirotaka Ata, Thomas L Ekstrom, Gabriel Martínez-Gálvez, Carla M Mann, Alexey V Dvornikov, Kyle J Schaefbauer, Alvin C Ma, Drena Dobbs, Karl J Clark, Stephen C Ekker
Publikováno v:
PLoS Genetics, Vol 14, Iss 9, p e1007652 (2018)
One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This is due to the typical activation of the versatile Non-homologous End Joining (NHEJ) pathwa
Externí odkaz:
https://doaj.org/article/c85c3d9fa6a447a88aba7e6859d8e799
Autor:
Maengjo Kim, Linghui Lu, Alexey V. Dvornikov, Xiao Ma, Yonghe Ding, Ping Zhu, Timothy M. Olson, Xueying Lin, Xiaolei Xu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 11, p 5494 (2021)
A de novo missense variant in Rag GTPase protein C (RagCS75Y) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish RragcS
Externí odkaz:
https://doaj.org/article/552f61c315bd48e4b10d95161fbbbb08
Publikováno v:
Journal of General Physiology. 155
Cardiac muscle contraction is regulated by Ca2+-induced structural changes of the thin filaments to permit myosin cross-bridge cycling driven by ATP hydrolysis in the sarcomere. In congestive heart failure, contraction is weakened, and thus targeting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6a033528dcba218acf78a19d1c5c34a0
https://doi.org/10.1085/jgp.202113054
https://doi.org/10.1085/jgp.202113054
Autor:
Hong Zhang, Alexey V. Dvornikov, Inken G. Huttner, Xiao Ma, Celine F. Santiago, Diane Fatkin, Xiaolei Xu
Publikováno v:
Disease Models & Mechanisms, Vol 11, Iss 9 (2018)
Zebrafish are increasingly used as a vertebrate model to study human cardiovascular disorders. Although heart structure and function are readily visualized in zebrafish embryos because of their optical transparency, the lack of effective tools for ev
Externí odkaz:
https://doaj.org/article/8f9df466e87c460fa9a59ce2419ac903
Publikováno v:
Biophysical Journal. 122:402a-403a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71f0e644c08f9d9f3a40e907c4d5d262
https://doi.org/10.1016/j.bpj.2022.11.2193
https://doi.org/10.1016/j.bpj.2022.11.2193
Autor:
Xiaolei Xu, Linghui Lu, Alexey V. Dvornikov, Xueying Lin, Xiao Ma, Maengjo Kim, Timothy M. Olson, Yonghe Ding, Ping Zhu
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 5494, p 5494 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences
Volume 22
Issue 11
A de novo missense variant in Rag GTPase protein C (RagCS75Y) was recently identified in a syndromic dilated cardiomyopathy (DCM) patient. However, its pathogenicity and the related therapeutic strategy remain unclear. We generated a zebrafish RragcS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df655d7bd880cc01bb7cf2647f6272a1
https://www.mdpi.com/1422-0067/22/11/5494
https://www.mdpi.com/1422-0067/22/11/5494
Autor:
Alexey V. Dvornikov, Yong Wang, Qi Qiu, Xueying Lin, Tzung K. Hsiai, Xiaolei Xu, Yonghe Ding, Maengjo Kim, Zhang Hong, Yue Yu, Nadine Norton, Joerg Herrmann, Matthew R. Lowerison, Stephen C. Ekker, Xiao Ma, Ping Zhu, Zheng Wang
Publikováno v:
Science Advances
RXRA is an endothelial- and early stage–predominant therapeutic target for treating anthracycline-induced cardiotoxicity.
To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor
To uncover the genetic basis of anthracycline-induced cardiotoxicity (AIC), we recently established a genetic suppressor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b7eed57b7b12da0e51074f7123b42dd
http://europepmc.org/articles/PMC6989136
http://europepmc.org/articles/PMC6989136
Publikováno v:
Biophysical Journal. 121:107a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2102188f3cd1a869705c65da41270a18
https://doi.org/10.1016/j.bpj.2021.11.2183
https://doi.org/10.1016/j.bpj.2021.11.2183
Autor:
Tai Le, Ping Zhu, Xueying Lin, Alexey V. Dvornikov, Hung Cao, Xiaolei Xu, Mingmin Wang, Jingchun Yang
Publikováno v:
J Mol Cell Cardiol
Adult zebrafish is an emerging vertebrate model for studying genetic basis of cardiomyopathies; but whether the simple fish heart can model essential features of hypertrophic cardiomyopathy (HCM) remained unknown. Here, we report a comprehensive phen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46b4e1a74dae3c62588620495c148178
https://europepmc.org/articles/PMC6705397/
https://europepmc.org/articles/PMC6705397/
Autor:
Xiaolei Xu, Wang Lei, René R. Sevag Packard, Yong Wang, Alexey V. Dvornikov, Tzung K. Hsiai, Matthew R. Lowerison, Yonghe Ding, Yuji Zhang, Xiao Ma, Zhang Hong, Jun Chen, Xueying Lin
Publikováno v:
Disease Models & Mechanisms, Vol 12, Iss 10 (2019)
Disease Models & Mechanisms
Disease Models & Mechanisms
The adult zebrafish is an emerging vertebrate model for studying human cardiomyopathies; however, whether the simple zebrafish heart can model different subtypes of cardiomyopathies, such as dilated cardiomyopathy (DCM), remains elusive. Here, we gen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8571dbb218032865f36146c5cb94962
https://doi.org/10.1242/dmm.040154
https://doi.org/10.1242/dmm.040154