Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Alexey V, Terskikh"'
Publikováno v:
PLoS Pathogens, Vol 19, Iss 11, p e1011795 (2023)
Zika virus (ZIKV) serine protease, indispensable for viral polyprotein processing and replication, is composed of the membrane-anchored NS2B polypeptide and the N-terminal domain of the NS3 polypeptide (NS3pro). The C-terminal domain of the NS3 polyp
Externí odkaz:
https://doaj.org/article/a44671cfe2884cf18d9a0f2f1d244e9c
Autor:
Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben Abagyan
Publikováno v:
Viruses, Vol 15, Iss 5, p 1106 (2023)
The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic p
Externí odkaz:
https://doaj.org/article/d82dfc16c47e4ce8a8d1bcd1aada43df
Autor:
Shichun Tu, Mohd Waseem Akhtar, Rosa Maria Escorihuela, Alejandro Amador-Arjona, Vivek Swarup, James Parker, Jeffrey D. Zaremba, Timothy Holland, Neha Bansal, Daniel R. Holohan, Kevin Lopez, Scott D. Ryan, Shing Fai Chan, Li Yan, Xiaofei Zhang, Xiayu Huang, Abdullah Sultan, Scott R. McKercher, Rajesh Ambasudhan, Huaxi Xu, Yuqiang Wang, Daniel H. Geschwind, Amanda J. Roberts, Alexey V. Terskikh, Robert A. Rissman, Eliezer Masliah, Stuart A. Lipton, Nobuki Nakanishi
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Human MEF2C haploinsufficiency results in Autism Spectrum Disorder (ASD), but it is unclear if the same is true in mice. Here, the authors show that Mef2c +/− mice have behavioral defects and neuronal abnormalities similar to ASD, and symptoms can
Externí odkaz:
https://doaj.org/article/386d48d4311a447bb8bff05a85d294e7
Autor:
Lizhu Lin, Antonella Pinto, Lu Wang, Kazumi Fukatsu, Yan Yin, Simon D Bamforth, Marianne E Bronner, Sylvia M Evans, Shuyi Nie, Robert H Anderson, Alexey V Terskikh, Paul D Grossfeld
Publikováno v:
Hum Mol Genet
Ets1 deletion in some mouse strains causes septal defects and has been implicated in human congenital heart defects in Jacobsen syndrome, in which one copy of the Ets1 gene is missing. Here, we demonstrate that loss of Ets1 in mice results in a decre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530fac0d4e1c244c0f83930bff3b4991
https://doi.org/10.1093/hmg/ddac174
https://doi.org/10.1093/hmg/ddac174
Autor:
Chen Farhy, Santosh Hariharan, Jarkko Ylanko, Luis Orozco, Fu-Yue Zeng, Ian Pass, Fernando Ugarte, E Camilla Forsberg, Chun-Teng Huang, David W Andrews, Alexey V Terskikh
Publikováno v:
eLife, Vol 8 (2019)
High-content phenotypic screening has become the approach of choice for drug discovery due to its ability to extract drug-specific multi-layered data. In the field of epigenetics, such screening methods have suffered from a lack of tools sensitive to
Externí odkaz:
https://doaj.org/article/fb99e0c9b5244cc5b41abdc773f659fd
Autor:
Kirill Gorshkov, Sergey A. Shiryaev, Sophie Fertel, Yi-Wen Lin, Chun-Teng Huang, Antonella Pinto, Chen Farhy, Alex Y. Strongin, Wei Zheng, Alexey V. Terskikh
Publikováno v:
Frontiers in Microbiology, Vol 9 (2019)
The Zika virus (ZIKV) global epidemic prompted the World Health Organization to declare it a 2016 Public Health Emergency of International Concern. The overwhelming experience over the past several years teaches us that ZIKV and the associated neurol
Externí odkaz:
https://doaj.org/article/dd5be0a89fd44eb9ba2f5811cd94e421
Autor:
Abagyan, Ittipat Meewan, Sergey A. Shiryaev, Julius Kattoula, Chun-Teng Huang, Vivian Lin, Chiao-Han Chuang, Alexey V. Terskikh, Ruben
Publikováno v:
Viruses; Volume 15; Issue 5; Pages: 1106
The Zika virus (ZIKV), a member of the Flaviviridae family, is considered a major health threat causing multiple cases of microcephaly in newborns and Guillain-Barré syndrome in adults. In this study, we targeted a transient, deep, and hydrophobic p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::6e8856941cdcf24bb21a63e63392f593
Autor:
Alexey V. Terskikh, Robert G. Oshima, John Hassell, Jacqueline Lesperance, Amber Miller, Jochen Maurer, Lionel W. Hebbard
Maternal embryonic leucine zipper kinase (MELK) is expressed in several developing tissues, in the adult germ line, and in adult neural progenitors. MELK expression is elevated in aggressive undifferentiated tumors, correlating with poor patient outc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fe2eddb8b0cbb2f988eff3ec77adef1
https://doi.org/10.1158/0008-5472.c.6500760
https://doi.org/10.1158/0008-5472.c.6500760
Autor:
Alexey V. Terskikh, Robert G. Oshima, John Hassell, Jacqueline Lesperance, Amber Miller, Jochen Maurer, Lionel W. Hebbard
Supplementary Protocols from Maternal Embryonic Leucine Zipper Kinase Is Upregulated and Required in Mammary Tumor-Initiating Cells In vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066c181418872ea36f1abb60c0b9bdd5
https://doi.org/10.1158/0008-5472.22384068
https://doi.org/10.1158/0008-5472.22384068
Autor:
Delany Rodriguez, Martin Alvarez-Kuglen, Haodong Qin, Lorenzo Fiengo, Chen Farhy, Wei-Mien Hsu, Aaron Havas, Rozalyn M. Anderson, Amanda J. Roberts, Peter D. Adams, Tatyana O. Sharpee, Alexey V. Terskikh
Predictive biomarkers of functional or biological age are key for evaluating interventions aimed at increasing healthspan and, perhaps, lifespan in humans. Currently, cardiovascular performance, blood analytes, frailty indices, and DNA methylation cl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ffbb5a4fbca3cd5410758de6bc63b42
https://doi.org/10.1101/2022.10.16.512441
https://doi.org/10.1101/2022.10.16.512441