Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Alexey Tomilin"'
Autor:
Aleksandr Khudiakov, Daria Kostina, Anna Zlotina, Tatiana Nikulina, Alexey Sergushichev, Alexandra Gudkova, Alexey Tomilin, Anna Malashicheva, Anna Kostareva
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 77-80 (2017)
Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying desmin (DES) gene heterozygous splice site mutation using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4
Externí odkaz:
https://doaj.org/article/45f0b317b1c54f84a10dff71d781ba17
Autor:
Aleksandr Khudiakov, Daria Kostina, Anna Zlotina, Natalia Yany, Alexey Sergushichev, Tatiana Pervunina, Alexey Tomilin, Anna Kostareva, Anna Malashicheva
Publikováno v:
Stem Cell Research, Vol 24, Iss C, Pp 85-88 (2017)
Human iPSC line was generated from patient-specific adipose tissue-derived mesenchymal multipotent stromal cells carrying two mutations in plakophilin-2 (PKP2) gene using non-integrative reprogramming method. Reprogramming factors OCT4, KLF4, SOX2, C
Externí odkaz:
https://doaj.org/article/e11eb0b45416498683b2ca1ed8dd0c40
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 21, p 7948 (2020)
The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose interactions with DNA as well as with other proteins lead to the formation of a complicated, organized, and quite dynamic system known as chromatin. This review i
Externí odkaz:
https://doaj.org/article/70b1c885d74a45719d55f20baa701aa7
Autor:
Brian DeVeale, Irina Brokhman, Paria Mohseni, Tomas Babak, Charles Yoon, Anthony Lin, Kento Onishi, Alexey Tomilin, Larysa Pevny, Peter W Zandstra, Andras Nagy, Derek van der Kooy
Publikováno v:
PLoS Genetics, Vol 9, Iss 11, p e1003957 (2013)
Oct4 is a widely recognized pluripotency factor as it maintains Embryonic Stem (ES) cells in a pluripotent state, and, in vivo, prevents the inner cell mass (ICM) in murine embryos from differentiating into trophectoderm. However, its function in som
Externí odkaz:
https://doaj.org/article/78f41e00bb37438884efa63e55559052
Autor:
Mikhail Liskovykh, Ilya Chuykin, Ashish Ranjan, Dina Safina, Elena Popova, Elena Tolkunova, Valentina Mosienko, Julia M Minina, Natalia S Zhdanova, John J Mullins, Michael Bader, Natalia Alenina, Alexey Tomilin
Publikováno v:
PLoS ONE, Vol 6, Iss 11, p e27345 (2011)
The rat represents an important animal model that, in many respects, is superior to the mouse for dissecting behavioral, cardiovascular and other physiological pathologies relevant to humans. Derivation of induced pluripotent stem cells from rats (ri
Externí odkaz:
https://doaj.org/article/74b1ba3a139f4c929b2668fb6f3c4ba8
Publikováno v:
PLoS ONE, Vol 4, Iss 2, p e4467 (2009)
Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation. It is essential for maintenance of undifferentiated, pluripotent cell populations, and accomplishes these tasks by binding DNA i
Externí odkaz:
https://doaj.org/article/0007ea3f037147e499945f521899d205
Autor:
Alexey Tomilin, E. I. Bakhmet
Publikováno v:
Cellular and Molecular Life Sciences. 78:7339-7353
Oct4, a class V POU-domain protein that is encoded by the Pou5f1 gene, is thought to be a key transcription factor in the early development of mammals. This transcription factor plays indispensable roles in pluripotent stem cells as well as in the ac
Autor:
Tatiana Starkova, Alexander Polyanichko, Tatiana Artamonova, Anna Tsimokha, Alexey Tomilin, Elena Chikhirzhina
Publikováno v:
International Journal of Molecular Sciences; Volume 24; Issue 4; Pages: 3577
Non-histone nuclear proteins HMGB1 and HMGB2 (High Mobility Group) are involved in many biological processes, such as replication, transcription, and repair. The HMGB1 and HMGB2 proteins consist of a short N-terminal region, two DNA-binding domains,
Publikováno v:
Cell and Tissue Biology. 15:44-50
The ubiquitin-proteasome system is involved in the regulation of most major intracellular processes, and disruptions in the functioning of this system lead to various pathologies. The proteolytic core of this system, 20S proteasome, was found in the
Autor:
I. B. Nazarov, S. V. Ponomartsev, E. V. Potapenko, N. D. Aksenov, Alexey Tomilin, Mikhail Gordeev, P. A. Dyban, Andrey A. Kuzmin, E. I. Bakhmet
Publikováno v:
Cell and Tissue Biology. 14:413-418
KH-domain PolyC-binding proteins perform many functions ranging from transcription regulation to alternative splicing. There are several evidences of their important role in embryogenesis and in embryonic stem cells (ESCs). ESCs are cultured counterp