Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Alexey Shalygin"'
Autor:
Konstantin Gusev, Alexey Shalygin, Dmitrii Kolesnikov, Leonid Shuyskiy, Sofia Makeenok, Lyubov Glushankova, Konstantin Sivak, Kirill Yakovlev, Yana Orshanskaya, Guanghui Wang, Andrey Bakhtyukov, Kira Derkach, Alexander Shpakov, Elena Kaznacheyeva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7259 (2023)
Type 2 diabetes mellitus (DM2) is a widespread metabolic disorder that results in podocyte damage and diabetic nephropathy. Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is associat
Externí odkaz:
https://doaj.org/article/9b7698ee08bd46609be2f91c51036368
Autor:
Ksenia Skobeleva, Alexey Shalygin, Elena Mikhaylova, Irina Guzhova, Maria Ryazantseva, Elena Kaznacheyeva
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 14810 (2022)
Alzheimer’s disease (AD) is the most common cause of age-related dementia. Neuronal calcium homeostasis impairment may contribute to AD. Here we demonstrated that voltage-gated calcium (VGC) entry and store-operated calcium (SOC) entry regulated by
Externí odkaz:
https://doaj.org/article/1da836fe301c405baf7e4ba34a464d39
Autor:
Alexey Shalygin, Leonid S. Shuyskiy, Ruslan Bohovyk, Oleg Palygin, Alexander Staruschenko, Elena Kaznacheyeva
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4396 (2021)
The actin cytoskeleton of podocytes plays a central role in the functioning of the filtration barrier in the kidney. Calcium entry into podocytes via TRPC6 (Transient Receptor Potential Canonical 6) channels leads to actin cytoskeleton rearrangement,
Externí odkaz:
https://doaj.org/article/db1fd37ad20e489bbcfeb28117a34927
Autor:
Dmitrii Kolesnikov, Anastasiia Perevoznikova, Konstantin Gusev, Lyubov Glushankova, Elena Kaznacheyeva, Alexey Shalygin
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 9, p 4767 (2021)
Microdomains formed by proteins of endoplasmic reticulum and plasma membrane play a key role in store-operated Ca2+ entry (SOCE). Ca2+ release through inositol 1,4,5-trisphosphate receptor (IP3R) and subsequent Ca2+ store depletion activate STIM (str
Externí odkaz:
https://doaj.org/article/e5cddb9cd6944bedbfeed7c072993664
Autor:
Vladimir Vigont, Evgeny Nekrasov, Alexey Shalygin, Konstantin Gusev, Sergey Klushnikov, Sergey Illarioshkin, Maria Lagarkova, Sergey L. Kiselev, Elena Kaznacheyeva
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
Neurodegenerative pathologies are among the most serious and socially significant problems of modern medicine, along with cardiovascular and oncological diseases. Several attempts have been made to prevent neuronal death using novel drugs targeted to
Externí odkaz:
https://doaj.org/article/37561a70256a4dc488738b4fe63e6e30
Autor:
Elena Isaeva, Ruslan Bohovyk, Mykhailo Fedoriuk, Alexey Shalygin, Christine A. Klemens, Adrian Zietara, Vladislav Levchenko, Jerod S. Denton, Alexander Staruschenko, Oleg Palygin
Publikováno v:
British Journal of Pharmacology. 179:2953-2968
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa4daddfa5e0f3db68924396ccd7ff09
https://doi.org/10.1111/bph.15779
https://doi.org/10.1111/bph.15779
Autor:
Konstantin Gusev, Alexey Shalygin, Dmitrii Kolesnikov, Leonid Shuyskiy, Sofia Makeenok, Lyubov Glushankova, Konstantin Sivak, Kirill Yakovlev, Yana Orshanskaya, Guanghui Wang, Andrey Bakhtyukov, Kira Derkach, Alexander Shpakov, Elena Kaznacheyeva
Type 2 diabetes mellitus (DM2) is a widespread metabolic disorder that results in podocyte damage and diabetic nephropathy. Previous studies demonstrated that TRPC6 channels play a pivotal role in podocyte function and their dysregulation is associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fdb0765b07b972448abfb9cdfc95259
https://doi.org/10.21203/rs.3.rs-2511159/v1
https://doi.org/10.21203/rs.3.rs-2511159/v1
Autor:
Alexey Shalygin, Andrey D. Grigoryev, Anton Skopin, L. N. Glushankova, Guanghui Wang, Elena Kaznacheyeva, Viktor G. Kartzev
Publikováno v:
Acta Naturae
Store-operated Ca2+ entry is one of the main pathways of calcium influx into non-excitable cells, which entails the initiation of many intracellular processes. The endoplasmic reticulum Ca2+ sensors STIM1 and STIM2 are the key components of store-ope
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef1829ff0751e19a20095a538012703d
https://doi.org/10.32607/actanaturae.11269
https://doi.org/10.32607/actanaturae.11269
Autor:
V V Vigont, E V Kaznacheeva, Konstantin Gusev, L. N. Glushankova, Alexey Shalygin, D A Grekhnev
Publikováno v:
Bulletin of Experimental Biology and Medicine. 167:311-314
The fluorescent dye fura-2 AM was employed to record activation of Ca2+ entry in response to a decrease in Ca2+ concentration in the endoplasmic reticulum. Using whole-cell voltage clamp technique, we revealed Ca2+ currents with an amplitude of 0.46
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c8f496938dc322c049b9ea7598cbd78
https://doi.org/10.1007/s10517-019-04516-x
https://doi.org/10.1007/s10517-019-04516-x
Autor:
Alexander Staruschenko, Oleg Palygin, Vladislav Levchenko, Christine A. Klemens, Jerod S. Denton, Mykhailo Fedoriuk, Alexey Shalygin, Elena Isaeva, Ruslan Bohovyk, Adrian Zietara
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1f7c60c5602740bc773efeab6145746b
https://doi.org/10.1096/fasebj.2021.35.s1.02816
https://doi.org/10.1096/fasebj.2021.35.s1.02816