Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Alexey Schulga"'
Autor:
Sergey M. Deyev, Maryam Oroujeni, Javad Garousi, Torbjörn Gräslund, Ruonan Li, Alia Hani Binti Rosly, Anna Orlova, Elena Konovalova, Alexey Schulga, Anzhelika Vorobyeva, Vladimir Tolmachev
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4246 (2024)
Designed ankyrin repeat protein (DARPin) G3 is an engineered scaffold protein. This small (14.5 kDa) targeting protein binds with high affinity to human epidermal growth factor receptor 2 (HER2). HER2 is overexpressed in several cancers. The use of t
Externí odkaz:
https://doaj.org/article/12a7cc2e5d4d4661b07a0431cf300507
Autor:
Olga Bragina, Vladimir Chernov, Alexey Schulga, Elena Konovalova, Sophia Hober, Sergey Deyev, Jens Sörensen, Vladimir Tolmachev
Publikováno v:
Cancers, Vol 15, Iss 12, p 3149 (2023)
Previous Phase I clinical evaluations of the radiolabelled scaffold proteins [99mTc]Tc-ADAPT6 and DARPin [99mTc]Tc-(HE)3-G3 in breast cancer patients have demonstrated their safety and indicated their capability to discriminate between HER2-positive
Externí odkaz:
https://doaj.org/article/b611e0ea26df41e98e9523d346e9b9e5
Autor:
Tianqi Xu, Alexey Schulga, Elena Konovalova, Sara S. Rinne, Hongchao Zhang, Olga Vorontsova, Anna Orlova, Sergey M. Deyev, Vladimir Tolmachev, Anzhelika Vorobyeva
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2838 (2023)
Pancreatic cancer (PC) is one of the most aggressive malignancies. A combination of targeted therapies could increase the therapeutic efficacy in tumors with heterogeneous target expression. Overexpression of the human epidermal growth factor recepto
Externí odkaz:
https://doaj.org/article/9a603907de48471298e2d0964df39533
Autor:
Vladimir Tolmachev, Vitalina Bodenko, Maryam Oroujeni, Sergey Deyev, Elena Konovalova, Alexey Schulga, Sarah Lindbo, Sophia Hober, Olga Bragina, Anna Orlova, Anzhelika Vorobyeva
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 23, p 15181 (2022)
Non-invasive radionuclide molecular visualization of human epidermal growth factor receptor type 2 (HER2) can provide stratification of patients for HER2-targeting therapy. This method can also enable monitoring of the response to such therapies, the
Externí odkaz:
https://doaj.org/article/1993c20ee1914f64be505194cea7d552
Autor:
Mohamed Altai, Javad Garousi, Sara S. Rinne, Alexey Schulga, Sergey Deyev, Anzhelika Vorobyeva
Publikováno v:
EJNMMI Research, Vol 10, Iss 1, Pp 1-8 (2020)
Abstract Background Designed ankyrin repeat proteins (DARPins) are small engineered scaffold proteins (14–18 kDa) that demonstrated promising tumor-targeting properties in preclinical studies. However, high renal accumulation of activity for DARPin
Externí odkaz:
https://doaj.org/article/1cdec13355ae4c87aaae315f15791931
Autor:
Mariia Larkina, Evgenii Plotnikov, Ekaterina Bezverkhniaia, Yulia Shabanova, Maria Tretyakova, Feruza Yuldasheva, Roman Zelchan, Alexey Schulga, Elena Konovalova, Anzhelika Vorobyeva, Javad Garousi, Torbjörn Gräslund, Mikhail Belousov, Vladimir Tolmachev, Sergey Deyev
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 21, p 13443 (2022)
Non-invasive radionuclide imaging of human epidermal growth factor receptor type 2 (HER2) expression in breast, gastroesophageal, and ovarian cancers may stratify patients for treatment using HER2-targeted therapeutics. Designed ankyrin repeat protei
Externí odkaz:
https://doaj.org/article/b1a64337c5e043cb8be0635e815b0d3f
Autor:
Andrey Bogorodskiy, Ivan Okhrimenko, Ivan Maslov, Nina Maliar, Dmitrii Burkatovskii, Florian von Ameln, Alexey Schulga, Philipp Jakobs, Joachim Altschmied, Judith Haendeler, Alexandros Katranidis, Ivan Sorokin, Alexey Mishin, Valentin Gordeliy, Georg Büldt, Wolfgang Voos, Thomas Gensch, Valentin Borshchevskiy
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Mitochondrial protein biogenesis relies almost exclusively on the expression of nuclear-encoded polypeptides. The current model postulates that most of these proteins have to be delivered to their final mitochondrial destination after their synthesis
Externí odkaz:
https://doaj.org/article/16e2a2506edb4cd58990e060d3ca145f
Autor:
Tianqi Xu, Anzhelika Vorobyeva, Alexey Schulga, Elena Konovalova, Olga Vorontsova, Haozhong Ding, Torbjörn Gräslund, Liubov A. Tashireva, Anna Orlova, Vladimir Tolmachev, Sergey M. Deyev
Publikováno v:
Cancers, Vol 13, Iss 16, p 3939 (2021)
Efficient treatment of disseminated ovarian cancer (OC) is challenging due to its heterogeneity and chemoresistance. Overexpression of human epidermal growth factor receptor 2 (HER2) and epithelial cell adhesion molecule (EpCAM) in approx. 30% and 70
Externí odkaz:
https://doaj.org/article/15b5b7795c4f42b98664a33255ce8aee
Autor:
Sergey M. Deyev, Tianqi Xu, Yongsheng Liu, Alexey Schulga, Elena Konovalova, Javad Garousi, Sara S. Rinne, Maria Larkina, Haozhong Ding, Torbjörn Gräslund, Anna Orlova, Vladimir Tolmachev, Anzhelika Vorobyeva
Publikováno v:
Cancers, Vol 13, Iss 14, p 3589 (2021)
The epithelial cell adhesion molecule (EpCAM) is intensively overexpressed in 40–60% of prostate cancer (PCa) cases and can be used as a target for the delivery of drugs and toxins. The designed ankyrin repeat protein (DARPin) Ec1 has a high affini
Externí odkaz:
https://doaj.org/article/30a2d0c61c974613acc33ff194aec89c
Autor:
Anzhelika Vorobyeva, Ekaterina Bezverkhniaia, Elena Konovalova, Alexey Schulga, Javad Garousi, Olga Vorontsova, Ayman Abouzayed, Anna Orlova, Sergey Deyev, Vladimir Tolmachev
Publikováno v:
Molecules, Vol 25, Iss 20, p 4719 (2020)
Efficient treatment of disseminated triple-negative breast cancer (TNBC) remains an unmet clinical need. The epithelial cell adhesion molecule (EpCAM) is often overexpressed on the surface of TNBC cells, which makes EpCAM a potential therapeutic targ
Externí odkaz:
https://doaj.org/article/c156c6384f714624808c4eba38498ace