Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Alexey Obolensky"'
Autor:
Yogapriya Sundaresan, Antonio Rivera, Alexey Obolensky, Prakadeeswari Gopalakrishnan, Hanit Ohayon Hadad, Aya Shemesh, Samer Khateb, Maya Ross, Ron Ofri, Sharon Durst, Hadas Newman, Rina Leibu, Shiri Soudry, Dinah Zur, Tamar Ben-Yosef, Eyal Banin, Dror Sharon
Publikováno v:
Genes, Vol 15, Iss 6, p 804 (2024)
Retinitis pigmentosa (RP) is a heterogeneous inherited retinal disorder. Mutations in KIZ cause autosomal recessive (AR) RP. We aimed to characterize the genotype, expression pattern, and phenotype in a large cohort of KIZ cases. Sanger and whole exo
Externí odkaz:
https://doaj.org/article/586c2808fa8c4ba4aec928c15384719d
Autor:
Chen Matsevich, MSc, Prakadeeswari Gopalakrishnan, PhD, Alexey Obolensky, MD, PhD, Eyal Banin, MD, PhD, Dror Sharon, PhD, Avigail Beryozkin, PhD
Publikováno v:
Ophthalmology Science, Vol 3, Iss 1, Pp 100229- (2023)
Purpose: Pathogenic variants in FAM161A are the most common cause of retinitis pigmentosa in Israel. Two founder pathogenic variants explain the vast majority of cases of Jewish origin, 1 being a nonsense variant (p.Arg523∗). The aim of this study
Externí odkaz:
https://doaj.org/article/b00088d98ead49f984235a652f32a32d
Autor:
Avigail Beryozkin, Chen Matsevich, Alexey Obolensky, Corinne Kostic, Yvan Arsenijevic, Uwe Wolfrum, Eyal Banin, Dror Sharon
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract FAM161A mutations are the most common cause of inherited retinal degenerations in Israel. We generated a knockout (KO) mouse model, Fam161a tm1b/tm1b , lacking the major exon #3 which was replaced by a construct that include LacZ under the e
Externí odkaz:
https://doaj.org/article/ad0c300bad8c4e92b277d31a4d21ab58
Autor:
Masha Idelson, Ruslana Alper, Alexey Obolensky, Nurit Yachimovich-Cohen, Jacob Rachmilewitz, Ayala Ejzenberg, Ekaterina Beider, Eyal Banin, Benjamin Reubinoff
Publikováno v:
Stem Cell Reports, Vol 11, Iss 3, Pp 681-695 (2018)
Summary: Age-related macular degeneration is caused by dysfunction and loss of retinal pigment epithelium (RPE) cells, and their transplantation may rescue visual functions and delay disease progression. Human embryonic stem cells (hESCs) may be an u
Externí odkaz:
https://doaj.org/article/ea02bed29ef34c968c8108304902d184
Autor:
Victoria Peshti, Alexey Obolensky, Liat Nahum, Yariv Kanfi, Moran Rathaus, Maytal Avraham, Simon Tinman, Fredrick W Alt, Eyal Banin, Haim Y Cohen
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0176371 (2017)
The NAD+-dependent SIRT6 deacetylase was shown to be a major regulator of lifespan and healthspan. Mice deficient for SIRT6 develop a premature aging phenotype and metabolic defects, and die before four weeks of age. Thus, the effect of SIRT6 deficie
Externí odkaz:
https://doaj.org/article/5828971d35ea408f88520d5c4681d65c
Autor:
Michal Lederman, Shira Hagbi-Levi, Michelle Grunin, Alexey Obolensky, Eduard Berenshtein, Eyal Banin, Mordechai Chevion, Itay Chowers
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e87751 (2014)
Oxidative injury is involved in retinal and macular degeneration. We aim to assess if retinal degeneration associated with genetic defect modulates the retinal threshold for encountering additional oxidative challenges.Retinal oxidative injury was in
Externí odkaz:
https://doaj.org/article/34264103996e4f829ff4402d9ae43170
Autor:
Hamzah Aweidah, Chen Matsevich, Hanita Khaner, Masha Idelson, Ayala Ejzenberg, Benjamin Reubinoff, Eyal Banin, Alexey Obolensky
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics.
Autor:
Talya Millo, Antonio Rivera, Alexey Obolensky, Devora Marks-Ohana, Mingchu Xu, Yumei Li, Enosh Wilhelm, Prakadeeswari Gopalakrishnan, Menachem Gross, Boris Rosin, Mor Hanany, Andrew Webster, Anna Maria Tracewska, Robert K. Koenekoop, Rui Chen, Gavin Arno, Ora Schueler-Furman, Susanne Roosing, Eyal Banin, Dror Sharon
Publikováno v:
Genetics in Medicine, 24, 1523-1535
Genetics in Medicine, 24, 7, pp. 1523-1535
Genetics in Medicine, 24, 7, pp. 1523-1535
Item does not contain fulltext PURPOSE: This study aimed to investigate the clinical and genetic aspects of solute carrier (SLC) genes in inherited retinal diseases (IRDs). METHODS: Exome sequencing data were filtered to identify pathogenic variants
Autor:
Alaa Abu-Diab, Prakadeeswari Gopalakrishnan, Chen Matsevich, Marije de Jong, Alexey Obolensky, Ayat Khalaileh, Manar Salameh, Ayala Ejzenberg, Menachem Gross, Eyal Banin, Dror Sharon, Samer Khateb
Publikováno v:
Translational Vision Science & Technology. 12:3
Autor:
Chen, Matsevich, Prakadeeswari, Gopalakrishnan, Alexey, Obolensky, Eyal, Banin, Dror, Sharon, Avigail, Beryozkin
Publikováno v:
Ophthalmology science. 3(1)
Pathogenic variants inExperimental study of a mouse animal model.A total of 106HomozygousVisual and retinal function assessments, clinical imaging examinations, quantitative histology, and IHC studies of KI as compared with wild-type (WT) mice retina