Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Alexey M Belkin"'
Autor:
Bakhtiyor Yakubov, Lan Chen, Alexey M Belkin, Sheng Zhang, Bhadrani Chelladurai, Zhong-Yin Zhang, Daniela Matei
Publikováno v:
PLoS ONE, Vol 9, Iss 2, p e89285 (2014)
Tissue transglutaminase (TG2) mediates protein crosslinking through generation of ε-(γ-glutamyl) lysine isopeptide bonds and promotes cell adhesion through interaction with fibronectin (FN) and integrins. Cell adhesion to the peritoneal matrix regu
Externí odkaz:
https://doaj.org/article/0b0089e8a4af41a6a297290fe1fc4e5e
Publikováno v:
PLoS ONE, Vol 6, Iss 4, p e19414 (2011)
Although endosomal compartments have been suggested to play a role in unconventional protein secretion, there is scarce experimental evidence for such involvement. Here we report that recycling endosomes are essential for externalization of cytoplasm
Externí odkaz:
https://doaj.org/article/ad5212c6594344929111761f4cee4378
Autor:
Dudley K. Strickland, Alexey M. Belkin, Chunzhang Cao, Sergiy Yakovlev, Ling Chen, Li Zhang, Leonid Medved
Publikováno v:
Thrombosis and Haemostasis. 116:1122-1130
SummaryOur previous studies revealed that the interaction of fibrin with the very low density lipoprotein receptor (VLDLR) promotes transendothelial migration of leukocytes and thereby inflammation, and localised the fibrin-binding site to CR-domains
Autor:
Mary Kathryn Leonard, Alexey M. Belkin, Xiuwei H. Yang, Marian Novak, Anjan Kowluru, David M. Kaetzel
Publikováno v:
Experimental Dermatology
Expression of the metastasis suppressor NME1 in melanoma is associated with reduced cellular motility and invasion in vitro and metastasis in vivo, but the underlying molecular mechanisms are not completely understood. Herein, we report a novel mecha
Autor:
Gemma S. Cook, David M. Kaetzel, Alexey M. Belkin, Mary Kathryn Leonard, Marian Novak, Stuart G. Jarrett, Xiuwei Yang
Publikováno v:
Naunyn-Schmiedeberg's Archives of Pharmacology. 388:199-206
The NME1 gene represents the prototypical metastasis suppressor, whose expression inhibits cell motility and metastasis without impact on primary tumor growth in a number of different human cancers. This report outlines our recent efforts to define t
Autor:
Maria Nurminskaya, Richard L. Eckert, Gozde Colak, Mari T. Kaartinen, Kapil Mehta, Gail V.W. Johnson, Alexey M. Belkin
Publikováno v:
Physiological Reviews. 94:383-417
Transglutaminases (TGs) are multifunctional proteins having enzymatic and scaffolding functions that participate in regulation of cell fate in a wide range of cellular systems and are implicated to have roles in development of disease. This review hi
Publikováno v:
Thrombosis and Haemostasis. 112:1244-1251
SummaryUpon conversion of fibrinogen into fibrin, fibrinogen αC-domains containing the RGD recognition motif form ordered αC polymers. Our previous study revealed that polymerisation of these domains promotes integrin-dependent adhesion and spreadi
Publikováno v:
Journal of Vascular Research. 51:418-428
Background: Phenotypic switch of vascular smooth muscle cells (VSMCs) accompanies neointima formation and associates with vascular diseases. Platelet-derived growth factor (PDGF)-induced activation of PDGFR/Akt1 and β-catenin signaling pathways in V
Autor:
Maria Nurminskaya, Masashi Tawa, Hirotaka Iwasaki, Alexey M. Belkin, Tetsuro Ago, Camilla F Wenceslau, Ryu Matsuo, Lijun Shi, Masahiro Kamouchi, Satz Mengensatzproduktion, Takashi Shimosato, Zhencheng Li, Theodora Szasz, Ni Lu, Debabrata Mukhopadhyay, Takeshi Imamura, Evelyn C. Nieves Torres, Junya Kuroda, Ataru Nishimura, Akshaar Brahmbhatt, Tomio Okamura, Elizabeth P. Smith, Binxia Yang, Takanari Kitazono, Druckerei Stückle, Kuniyuki Nakamura, Sanjay Misra, Cameron G. McCarthy, Kelly E. Beazley, Yoshinobu Wakisaka, R. Clinton Webb
Publikováno v:
Journal of Vascular Research. 51:I-IV
Publikováno v:
Journal of Vascular Research. 50:383-395
Inward remodeling of small arteries occurs after prolonged vasoconstriction, low blood flow, and in several models of hypertension. The cross-linking enzyme, transglutaminases 2 (TG2), is able to induce inward remodeling and stiffening of arteries. T