Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Alexey Lyashkov"'
Autor:
Carlos J Nogueras‐Ortiz, Erden Eren, Pamela Yao, Elizabeth Calzada, Christopher Dunn, Olga Volpert, Francheska Delgado‐Peraza, Maja Mustapic, Alexey Lyashkov, F Javier Rubio, Michael Vreones, Lesley Cheng, Yang You, Andrew F Hill, Tsuneya Ikezu, Erez Eitan, Edward J Goetzl, Dimitrios Kapogiannis
Publikováno v:
Journal of Extracellular Vesicles, Vol 13, Iss 6, Pp n/a-n/a (2024)
Abstract Isolation of neuron‐derived extracellular vesicles (NDEVs) with L1 Cell Adhesion Molecule (L1CAM)‐specific antibodies has been widely used to identify blood biomarkers of CNS disorders. However, full methodological validation requires de
Externí odkaz:
https://doaj.org/article/6df60f35215049c1aa20aedfca6fedc4
Autor:
Robert A. Tumasian, Abhinav Harish, Gautam Kundu, Jen-Hao Yang, Ceereena Ubaida-Mohien, Marta Gonzalez-Freire, Mary Kaileh, Linda M. Zukley, Chee W. Chia, Alexey Lyashkov, William H. Wood, Yulan Piao, Christopher Coletta, Jun Ding, Myriam Gorospe, Ranjan Sen, Supriyo De, Luigi Ferrucci
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
As human skeletal muscle ages, gene expression programs change and reflect damage accumulation and homeostatic resilience mechanisms. Here, the authors present a detailed framework of the global transcriptome that characterizes skeletal muscle during
Externí odkaz:
https://doaj.org/article/fe1b133469394d2ea2f9de8c7479f7a6
Autor:
Ceereena Ubaida-Mohien, Sally Spendiff, Alexey Lyashkov, Ruin Moaddel, Norah J MacMillan, Marie-Eve Filion, Jose A Morais, Tanja Taivassalo, Luigi Ferrucci, Russell T Hepple
Publikováno v:
eLife, Vol 11 (2022)
Background: Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear. Methods: We performed muscle biopsies in 15 octogena
Externí odkaz:
https://doaj.org/article/d70107ce73954db9be622478812cdc45
Autor:
Ceereena Ubaida-Mohien, Alexey Lyashkov, Marta Gonzalez-Freire, Ravi Tharakan, Michelle Shardell, Ruin Moaddel, Richard D Semba, Chee W Chia, Myriam Gorospe, Ranjan Sen, Luigi Ferrucci
Publikováno v:
eLife, Vol 8 (2019)
A decline of skeletal muscle strength with aging is a primary cause of mobility loss and frailty in older persons, but the molecular mechanisms of such decline are not understood. Here, we performed quantitative proteomic analysis from skeletal muscl
Externí odkaz:
https://doaj.org/article/8526b9711c14407e80591bd524a3eed5
Autor:
Ceereena Ubaida-Mohien, Marta Gonzalez-Freire, Alexey Lyashkov, Ruin Moaddel, Chee W. Chia, Eleanor M. Simonsick, Ranjan Sen, Luigi Ferrucci
Publikováno v:
Frontiers in Physiology, Vol 10 (2019)
Muscle strength declines with aging and increasing physical activity is the only intervention known to attenuate this decline. In order to adequately investigate both preventive and therapeutic interventions against sarcopenia, a better understanding
Externí odkaz:
https://doaj.org/article/7c58d1cef94b476b95857a80d39ceee1
Autor:
Luigi Ferrucci, Julián Candia, Ceereena Ubaida-Mohien, Alexey Lyashkov, Nirad Banskota, Christiaan Leeuwenburgh, Stephanie Wohlgemuth, Jack M. Guralnik, Mary Kaileh, Dongxue Zhang, Robert Sufit, Supriyo De, Myriam Gorospe, Rachel Munk, Charlotte A. Peterson, Mary M. McDermott
Publikováno v:
Circulation Research. 132:1428-1443
Background: Few effective therapies exist to improve lower extremity muscle pathology and mobility loss due to peripheral artery disease (PAD), in part because mechanisms associated with functional impairment remain unclear. Methods: To better unders
Autor:
Helene Tigro, Makoto Shimozawa, Per Nilsson, Alexey Lyashkov, Mohammed Khadeer, Ivar Järving, Luigi Ferrucci, Ruth Shimmo, Jan Johansson, Ruin Moaddel
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 232:115465
Autor:
Dimitrios Tsitsipatis, Jennifer L. Martindale, Ceereena Ubaida‐Mohien, Alexey Lyashkov, Hagai Yanai, Amogh Kashyap, Chang Hoon Shin, Allison B. Herman, Eunbyul Ji, Jen‐Hao Yang, Rachel Munk, Christopher Dunn, Yevgeniya Lukyanenko, Xiaoling Yang, Chee W. Chia, Ajoy C. Karikkineth, Linda Zukley, Jarod D’Agostino, Mary Kaileh, Chang‐Yi Cui, Isabel Beerman, Luigi Ferrucci, Myriam Gorospe
Publikováno v:
Aging Cell. 21
Changes in the proteome of different human tissues with advancing age are poorly characterized. Here, we studied the proteins present in primary skin fibroblasts collected from 82 healthy individuals across a wide age spectrum (22-89 years old) who p
Autor:
Ceereena Ubaida-Mohien, Sally Spendiff, Alexey Lyashkov, Ruin Moaddel, Norah J MacMillan, Marie-Eve Filion, Jose A Morais, Tanja Taivassalo, Luigi Ferrucci, Russell T Hepple
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::916db679169452f9d02ba44ab029da8c
https://doi.org/10.7554/elife.74335.sa2
https://doi.org/10.7554/elife.74335.sa2
Autor:
Ceereena Ubaida-Mohien, Sally Spendiff, Alexey Lyashkov, Ruin Moaddel, Norah J MacMillan, Marie-Eve Filion, Jose A Morais, Tanja Taivassalo, Luigi Ferrucci, Russell T Hepple
Publikováno v:
eLife. 11
Background:Master athletes (MAs) prove that preserving a high level of physical function up to very late in life is possible, but the mechanisms responsible for their high function remain unclear.Methods:We performed muscle biopsies in 15 octogenaria