Zobrazeno 1 - 10
of 120
pro vyhledávání: '"Alexey Lagunin"'
Publikováno v:
Molecules, Vol 27, Iss 18, p 5875 (2022)
Human cytochrome P450 enzymes (CYPs) are heme-containing monooxygenases. This superfamily of drug-metabolizing enzymes is responsible for the metabolism of most drugs and other xenobiotics. The inhibition of CYPs may lead to drug–drug interactions
Externí odkaz:
https://doaj.org/article/1a6220d420be4d47b59682ba314b2c91
Publikováno v:
Frontiers in Microbiology, Vol 11 (2020)
The interaction of human immunodeficiency virus with human cells is responsible for all stages of the viral life cycle, from the infection of CD4+ cells to reverse transcription, integration, and the assembly of new viral particles. To date, a large
Externí odkaz:
https://doaj.org/article/6dde30fed07640d7b03873bc05a79afc
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 7, p e1006851 (2019)
Adverse drug effects (ADEs) are one of the leading causes of death in developed countries and are the main reason for drug recalls from the market, whereas the ADEs that are associated with action on the cardiovascular system are the most dangerous a
Externí odkaz:
https://doaj.org/article/71921499dd3746d9972d2e56ef5c52a7
Autor:
Alexander Dmitriev, Dmitry Filimonov, Alexey Lagunin, Dmitry Karasev, Pavel Pogodin, Anastasiya Rudik, Vladimir Poroikov
Publikováno v:
Molecules, Vol 24, Iss 21, p 3955 (2019)
Drug-drug interactions (DDIs) severity assessment is a crucial problem because polypharmacy is increasingly common in modern medical practice. Many DDIs are caused by alterations of the plasma concentrations of one drug due to another drug inhibiting
Externí odkaz:
https://doaj.org/article/e1e91bccf6e24c32be87ddd2d9fc62c7
Autor:
Olga Tarasova, Anastassia Rudik, Alexander Dmitriev, Alexey Lagunin, Dmitry Filimonov, Vladimir Poroikov
Publikováno v:
Molecules, Vol 22, Iss 12, p 2123 (2017)
Metabolism of xenobiotics (Greek xenos: exogenous substances) plays an essential role in the prediction of biological activity and testing for the subsequent research and development of new drug candidates. Integration of various methods and techniqu
Externí odkaz:
https://doaj.org/article/cb12990901c24af9b9f5e6a7ee456fd8
Autor:
Olga Popova, E. K. Ginter, Pavel Volchkov, S. A. Smirnikhina, Dmitriy Y. Trofimov, V. L. Izhevskaya, Denis S. Andreyuk, Maria V. Vorontsova, Alexey Lagunin, Elena Grebenshchikova, Pavel Tishchenko, Sergey I. Kutsev, Aleksandr V. Polyakov
Publikováno v:
Annals of the Russian academy of medical sciences. 76:86-92
The prospects for the human embryos genome editing cause intense debates both in the scientific community and in general public. While the main attention of scientists is focused on the safety, effectiveness and clinical feasibility of the inherited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e789e6b064fa1f59aea814e6b70116d6
https://doi.org/10.15690/vramn1269
https://doi.org/10.15690/vramn1269
Autor:
Vad. V. Negrebetsky, Anastasia D. Shagina, K. A. Sobyanin, Tatiana A. Shmigol, Evgeniya P. Kramarova, Alexey Lagunin, Yu. I. Baukov, D. N. Lyakhman, D. V. Tarasenko, D. I. Gonchar
Publikováno v:
Russian Chemical Bulletin. 70:479-486
A virtual set of new lactam-containing derivatives of arylsulfonylglycines 1a–d and 2a–d was designed and analyzed using structure–activity computer models (web-services PASS Online, AntiBac-Pred, and GUSAR Acutetoxicity). The antimicrobial act
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1dff890363fb7e6cdd73bb1951cbe4bb
https://doi.org/10.1007/s11172-021-3112-8
https://doi.org/10.1007/s11172-021-3112-8
Publikováno v:
Biomeditsinskaya Khimiya. 67:295-299
Metabolic stability refers to the susceptibility of compounds to the biotransformation; it is characterized by such pharmacokinetic parameters as half-life (T1/2) and clearance (CL). Generally, these parameters are estimated by in vitro assays, which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46575b648cf9ef42e5538fd381cee91
https://doi.org/10.18097/pbmc20216703295
https://doi.org/10.18097/pbmc20216703295
Autor:
N.Yu. Biziukova, N.S. Ionov, A. V. Rudik, Olga Tarasova, O.A. Gomazkov, Leonid A. Stolbov, D.A. Dmitriev, Sergey Ivanov, D.S. Druzhilovskiy, D.A. Karasev, P.I. Savosina, Dmitry Filimonov, P.V. Pogodin, B.N. Sobolev, A.V. Veselovsky, Alexey Lagunin
Publikováno v:
http://eng.biomos.ru/conference/articles.htm. 1:209-211
Drug repositioning – the discovery of new indications for the launched drugs – is the rapid natural response to viral infection SARS-CoV-2/COVID-19. We will consider the current state of research and development of repositioned pharmaceuticals fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0bdb40855dfd0620c67ef698bdb29304
https://doi.org/10.37747/2312-640x-2021-19-209-211
https://doi.org/10.37747/2312-640x-2021-19-209-211