Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Alexey Kostikov"'
Autor:
Alexander Thiel, Alexey Kostikov, Hailey Ahn, Youstina Daoud, Jean-Paul Soucy, Stephan Blinder, Carolin Jaworski, Carmen Wängler, Björn Wängler, Freimut Juengling, Shirin A. Enger, Ralf Schirrmacher
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 8, Iss 1, Pp 1-9 (2023)
Abstract Background Reduced expression or impaired signalling of tropomyosin receptor kinases (Trk receptors) are found in a vast spectrum of CNS disorders. [18F]TRACK is the first PET radioligand for TrkB/C with proven in vivo brain penetration and
Externí odkaz:
https://doaj.org/article/c2a2926d0215420eb0000e3e6b42c40c
Autor:
Ralf Schirrmacher, Justin J. Bailey, Andrew V. Mossine, Peter J. H. Scott, Lena Kaiser, Peter Bartenstein, Simon Lindner, David R. Kaplan, Alexey Kostikov, Gert Fricker, Anne Mahringer, Pedro Rosa-Neto, Esther Schirrmacher, Carmen Wängler, Björn Wängler, Alexander Thiel, Jean-Paul Soucy, Vadim Bernard-Gauthier
Publikováno v:
Pharmaceuticals, Vol 12, Iss 1, p 7 (2019)
The tropomyosin receptor kinases family (TrkA, TrkB, and TrkC) supports neuronal growth, survival, and differentiation during development, adult life, and aging. TrkA/B/C downregulation is a prominent hallmark of various neurological disorders includ
Externí odkaz:
https://doaj.org/article/81c09851e052457895b08cf3c726c7ee
Publikováno v:
Applied Sciences, Vol 2, Iss 2, Pp 277-302 (2012)
Silicon-[18F]fluorine (Si-18F) radiochemistry has recently emerged alongside other unconventional approaches such as aluminum-18F and boron-18F based labeling strategies, reshaping the landscape of modern 18F-radiochemistry. All these novel methodolo
Externí odkaz:
https://doaj.org/article/71b05d7ecb5c41f593941e926d5480de
Autor:
Björn Wängler, Klaus Jurkschat, Ralf Schirrmacher, Alexey Kostikov, Christian Rensch, Peter Bartenstein, Klaus Theodor Wanner, Georg Höfner, Thomas Zöller, Carmen Wängler, Ljuba Iovkova-Berends
Publikováno v:
Molecules, Vol 16, Iss 9, Pp 7458-7479 (2011)
The synthesis, radiolabeling and in vitro evaluation of new silicon-fluoride acceptor (SiFA) derivatized D2-receptor ligands is reported. The SiFA-technology simplifies the introduction of fluorine-18 into target specific biomolecules for Positron-Em
Externí odkaz:
https://doaj.org/article/8c491236d6294266aa96f7cecf7234c4
Autor:
Min Su Kang, Alexander Thiel, Ralf Schirrmacher, Vadim Bernard‐Gauthier, Carolin Jaworski, Andreas Dorian, Robert Hopewell, Thomas A Singleton, Stephan Blinder, Jean‐Paul Soucy, Pedro Rosa‐Neto, Alexey Kostikov
Publikováno v:
Alzheimer's & Dementia. 18
Autor:
Hussein, Bdair, Thomas A, Singleton, Karen, Ross, Dean, Jolly, Min Su, Kang, Arturo, Aliaga, Marius, Tuznik, Tanpreet, Kaur, Saïd, Yous, Jean-Paul, Soucy, Gassan, Massarweh, Peter J H, Scott, Robert, Koeppe, Gilberto, Spadoni, Annalida, Bedini, David A, Rudko, Gabriella, Gobbi, Chawki, Benkelfat, Pedro, Rosa-Neto, Allen F, Brooks, Alexey, Kostikov
Publikováno v:
ACS chemical neuroscience. 13(9)
Melatonin is a neurohormone that modulates several physiological functions in mammals through the activation of melatonin receptor type 1 and 2 (MT
Autor:
Hussein Bdair, Thomas A. Singleton, Karen Ross, Dean Jolly, Min Su Kang, Arturo Aliaga, Marius Tuznik, Tanpreet Kaur, Saïd Yous, Jean-Paul Soucy, Gassan Massarweh, Peter J. H. Scott, Robert Koeppe, Gilberto Spadoni, Annalida Bedini, David A. Rudko, Gabriella Gobbi, Chawki Benkelfat, Pedro Rosa-Neto, Allen F. Brooks, Alexey Kostikov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf8c432bd92806c0620b96eb5307754
https://hdl.handle.net/11576/2705671
https://hdl.handle.net/11576/2705671
Autor:
Arturo Aliaga, Vadim Bernard-Gauthier, Justin J. Bailey, Sangho Choi, Alexey Kostikov, Pedro Rosa-Neto, Ralf Schirrmacher, Hussein Bdair, Thomas A. Singleton
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 63:144-150
Herein we report an efficient radiolabeling of a 18 F-fluorinated derivative of dual inhibitor GW2580, with its subsequent evaluation as a positron emission tomography (PET) tracer candidate for imaging of two neuroreceptor targets implicated in the
Publikováno v:
Journal of Labelled Compounds and Radiopharmaceuticals. 62:860-864
We report an efficient protocol for the radiosynthesis of diastereomerically pure (E)-[11 C]ABP688, a positron emission tomography (PET) tracer for metabotropic glutamate type 5 (mGlu5) receptor imaging. The protocol reliably provides sterile and pyr
Autor:
Jean R. Séguin, Sylvia M. L. Cox, Alexey Kostikov, Stephanie G. Scala, Kelly Smart, Maria Tippler, Natalia Jaworska, Michel Boivin, Marco Leyton, Aliaksandr Shalai, Chawki Benkelfat
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 46:1175-1178
To determine how the low-affinity (Z)-isomer of the radiotracer [11C]ABP688 affects binding potential values in vivo in humans. High-resolution [11C]ABP688 PET scans were acquired on 74 healthy volunteers (25 male, 49 female, mean age 20 ± 3.0). The