Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Alexey J Merz"'
Autor:
Matthew L Schwartz, Daniel P Nickerson, Braden T Lobingier, Rachael L Plemel, Mengtong Duan, Cortney G Angers, Michael Zick, Alexey J Merz
Publikováno v:
eLife, Vol 6 (2017)
Zippering of SNARE complexes spanning docked membranes is essential for most intracellular fusion events. Here, we explore how SNARE regulators operate on discrete zippering states. The formation of a metastable trans-complex, catalyzed by HOPS and i
Externí odkaz:
https://doaj.org/article/0baf4a25cfe943f89e532ac2f3d2c013
Publikováno v:
eLife, Vol 6 (2017)
At physiological protein levels, the slow HOPS- and SNARE-dependent fusion which occurs upon complete SNARE zippering is stimulated by Sec17 and Sec18:ATP without requiring ATP hydrolysis. To stimulate, Sec17 needs its central residues which bind the
Externí odkaz:
https://doaj.org/article/fa380fd6b0cf429fbdcfa5fab9ea62c7
Publikováno v:
eLife, Vol 3 (2014)
Secretory and endolysosomal fusion events are driven by SNAREs and cofactors, including Sec17/α-SNAP, Sec18/NSF, and Sec1/Munc18 (SM) proteins. SMs are essential for fusion in vivo, but the basis of this requirement is enigmatic. We now report that,
Externí odkaz:
https://doaj.org/article/37bf2c9442994b53942e5c05f6ea59b8
Autor:
Daniel Lockshon, Carissa Perez Olsen, Christopher L Brett, Andrei Chertov, Alexey J Merz, Daniel A Lorenz, Marc R Van Gilst, Brian K Kennedy
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e45049 (2012)
Preservation of both the integrity and fluidity of biological membranes is a critical cellular homeostatic function. Signaling pathways that govern lipid bilayer fluidity have long been known in bacteria, yet no such pathways have been identified in
Externí odkaz:
https://doaj.org/article/6d006fe966ef4ab49fc12a2321c444c0
Publikováno v:
Traffic. 22:38-44
AP-3 (adaptor complex 3) mediates traffic from the late Golgi or early endosomes to late endosomal compartments. In mammals, mutations in AP-3 cause Hermansky-Pudlak Syndrome type 2, cyclic neutropenias, and a form of epileptic encephalopathy. In bud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c0f6f39bde02981bf43a1fd939c2ff5
https://doi.org/10.1111/tra.12772
https://doi.org/10.1111/tra.12772
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Phase separation in membranes creates domains enriched in specific components. To date, the best example of micrometer-scale phase separation in the membrane of an unperturbed, living cell occurs in a yeast (Saccharomyces cerevisiae) org
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3faa954213e1f142a50d5e221f827e88
https://doi.org/10.1073/pnas.2116007119
https://doi.org/10.1073/pnas.2116007119
Autor:
Sarah Keller, Chantelle Leveille, John Reinhard, Caitlin E. Cornell, Glennis E. Rayermann, Scott P. Rayermann, Christian Klose, Robert Ernst, Alexey J. Merz
Publikováno v:
Biophysical Journal. 122:8a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f11e0a9efac6e7163f0a470863f6b727
https://doi.org/10.1016/j.bpj.2022.11.273
https://doi.org/10.1016/j.bpj.2022.11.273
SUMMARYSNARE chaperones of the Sec1/mammalian Unc-18 (SM) family have critical roles in SNARE-mediated membrane fusion. Using SNARE and Sly1 mutants, and a newin vitroassay of fusion, we separate and assess proposed mechanisms through which Sly1 augm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79257f8fe01001989f068b416b7ed448
https://doi.org/10.1101/2020.01.16.909630
https://doi.org/10.1101/2020.01.16.909630
