Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Alexey Gutsol"'
Publikováno v:
Journal of Hypertension. 39:e51
Autor:
Chet E. Holterman, Douglas A. Gray, Wanling Pan, R. Todd Alexander, Naomi C. Boisvert, Josée Coulombe, Chris R. J. Kennedy, Alexey Gutsol
Publikováno v:
American journal of physiology. Renal physiology. 315(2)
Loss of ubiquitin COOH-terminal hydrolase L1 (UCHL1), a deubiquitinating enzyme required for neuronal function, led to hyperphosphatemia accompanied by phosphaturia in mice, while calcium homeostasis remained intact. We therefore investigated the mec
Autor:
Glaucia E. Callera, Alexey Gutsol, Augusto C. Montezano, Ying He, Rhian M. Touyz, Jose W. Correa, Tayze T. Antunes, Danielle Moorman, Aurelie Nguyen Dinh Cat, Kevin D. Burns, Ana M. Briones
Publikováno v:
Bioscience Reports
High doses of Ang II receptor (AT1R) blockers (ARBs) are renoprotective in diabetes. Underlying mechanisms remain unclear. We evaluated whether high/ultra-high doses of candesartan (ARB) up-regulate angiotensin-converting enzyme 2 (ACE2)/Ang II type
Publikováno v:
American Journal of Physiology-Lung Cellular and Molecular Physiology. 302:L13-L26
Actin polymerization (APM), regulated by Rho GTPases, promotes myocyte force generation. Hypoxia is known to impede postnatal disassembly of the actin cytoskeleton in pulmonary arterial (PA) myocytes. We compared basal and agonist-induced APM in myoc
Autor:
Glaucia E Callera, Danielle Zimermann, Jose Correa, Alexey Gutsol, Ying He, Alvaro Yogi, Aurelie Nguyen Dinh Cat, Ana Briones, Joe Zimpelmann, Kevin Burns, Rhian Touyz
Publikováno v:
Hypertension. 60
The renin-angiotensin system (RAS) plays a pivotal role in the pathophysiology of cardiovascular and kidney disease. Protection against kidney injury has been evidenced by high dose angiotensin II (Ang II) type 1 receptor (AT1R) blockers. In this stu
Autor:
Richard L. Hébert, Alexey Gutsol, Freddy Heitz, Kevin D. Burns, Chris R. J. Kennedy, Rhian M. Touyz, Augusto C. Montezano, Patrick Page, Cedric Szyndralewiez, Glaucia E. Callera, Mona Sedeek
Publikováno v:
American journal of physiology. Renal physiology. 299(6)
Molecular mechanisms underlying renal complications of diabetes remain unclear. We tested whether renal NADPH oxidase (Nox) 4 contributes to increased reactive oxygen species (ROS) generation and hyperactivation of redox-sensitive signaling pathways